Mapping the ligand-binding pocket of integrin alpha5beta1 using a gain-of-function approach. (Q41963794)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19747169%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

title

Mapping the ligand-binding pocket of integrin alpha5beta1 using a gain-of-function approach (English)

1 reference

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7 February 2020

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1 reference

3

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7 February 2020

Martin J. Humphries

5

1 reference

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7 February 2020

Paul Mould

1

1 reference

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7 February 2020

author name string

Ewa J Koper

2

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7 February 2020

Grit Zahn

4

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7 February 2020

language of work or name

English

0 references

publication date

11 November 2009

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7 February 2020

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7 February 2020

volume

424

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7 February 2020

issue

2

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7 February 2020

page(s)

179-189

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19747169%20AND%20SRC:MED&resulttype=core&format=json

Preclinical evaluation of the novel small-molecule integrin alpha5beta1 inhibitor JSM6427 in monkey and rabbit models of choroidal neovascularization

7 February 2020

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5 June 2018

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5 June 2018

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5 June 2018

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Linking integrin conformation to function

5 June 2018

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Volociximab, a chimeric monoclonal antibody that specifically binds alpha5beta1 integrin: a phase I, pharmacokinetic, and biological correlative study

5 June 2018

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Caveolin-1 regulates glioblastoma aggressiveness through the control of alpha(5)beta(1) integrin expression and modulates glioblastoma responsiveness to SJ749, an alpha(5)beta(1) integrin antagonist

5 June 2018

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Species differences in small molecule binding to alpha IIb beta 3 are the result of sequence differences in 2 loops of the alpha IIb beta propeller

5 June 2018

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Structural basis for distinctive recognition of fibrinogen γC peptide by the platelet integrin α IIb β 3

5 June 2018

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5 June 2018

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Loss of E-cadherin promotes ovarian cancer metastasis via alpha 5-integrin, which is a therapeutic target

5 June 2018

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Role of the beta-subunit arginine/lysine finger in integrin heterodimer formation and function

5 June 2018

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Inhibition of inflammatory lymphangiogenesis by integrin alpha5 blockade

5 June 2018

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Identification of multiple integrin beta1 homologs in zebrafish (Danio rerio)

5 June 2018

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Uniform overexpression and rapid accessibility of alpha5beta1 integrin on blood vessels in tumors

5 June 2018

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In vivo drug discovery in the zebrafish

5 June 2018

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Evidence that monoclonal antibodies directed against the integrin beta subunit plexin/semaphorin/integrin domain stimulate function by inducing receptor extension.

5 June 2018

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Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics

5 June 2018

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An integrin-dependent role of pouch endoderm in hyoid cartilage development

5 June 2018

1 reference

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Structure of integrin alpha5beta1 in complex with fibronectin

5 June 2018

1 reference

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Integrins: bidirectional, allosteric signaling machines

5 June 2018

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Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand

5 June 2018

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Crystal structure of the extracellular segment of integrin alpha Vbeta3

5 June 2018

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Identification and characterization of a novel fibronectin in zebrafish

5 June 2018

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Defining fibronectin's cell adhesion synergy site by site-directed mutagenesis

5 June 2018

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Regulation of angiogenesis in vivo by ligation of integrin alpha5beta1 with the central cell-binding domain of fibronectin

5 June 2018

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Splice variants of the Drosophila PS2 integrins differentially interact with RGD-containing fragments of the extracellular proteins tiggrin, ten-m, and D-laminin 2.

5 June 2018

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Phage libraries displaying cyclic peptides with different ring sizes: ligand specificities of the RGD-directed integrins

5 June 2018

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2.0 A crystal structure of a four-domain segment of human fibronectin encompassing the RGD loop and synergy region

5 June 2018

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Critical amino acid residues for ligand binding are clustered in a predicted beta-turn of the third N-terminal repeat in the integrin alpha 4 and alpha 5 subunits.

5 June 2018

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Isolation of a highly specific ligand for the alpha 5 beta 1 integrin from a phage display library.

5 June 2018

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Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule

5 June 2018

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An alpha5beta1 integrin inhibitor attenuates glioma growth

5 June 2018

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Modulation of hypoxia-induced neovascularization by JSM6427, an integrin alpha5beta1 inhibiting molecule

12 August 2018

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N-glycosylation of the beta-propeller domain of the integrin alpha5 subunit is essential for alpha5beta1 heterodimerization, expression on the cell surface, and its biological function.

12 August 2018

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Suppression and regression of choroidal neovascularization by systemic administration of an alpha5beta1 integrin antagonist

12 August 2018

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Ligand binding analysis for human alpha5beta1 integrin: strategies for designing new alpha5beta1 integrin antagonists

12 August 2018

1 reference

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Structure of an integrin-ligand complex deduced from solution x-ray scattering and site-directed mutagenesis.

12 August 2018

1 reference

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Amino acid residues in the alpha IIb subunit that are critical for ligand binding to integrin alpha IIbbeta 3 are clustered in the beta-propeller model

12 August 2018

1 reference

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Generation of a minimal alpha5beta1 integrin-Fc fragment

12 August 2018

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Fine mapping of inhibitory anti-alpha5 monoclonal antibody epitopes that differentially affect integrin-ligand binding.

12 August 2018

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The short amino acid sequence Pro-His-Ser-Arg-Asn in human fibronectin enhances cell-adhesive function.

12 August 2018

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PROCHECK: a program to check the stereochemical quality of protein structures

12 August 2018

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Integration and germ-line transmission of a pseudotyped retroviral vector in zebrafish

21 January 2018

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Integrin activation involves a conformational change in the alpha 1 helix of the beta subunit A-domain

21 January 2018

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Defining the Topology of Integrin α5β1-Fibronectin Interactions Using Inhibitory Anti-α5 and Anti-β1 Monoclonal Antibodies

21 January 2018

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Identification of Amino Acid Residues That Form Part of the Ligand-binding Pocket of Integrin α5β1

21 January 2018

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Molecular Basis of Ligand Recognition by Integrin α5β1

21 January 2018

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Molecular Basis of Ligand Recognition by Integrin α5β1

21 January 2018

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Conformational Changes in the Integrin βA Domain Provide a Mechanism for Signal Transduction via Hybrid Domain Movement

21 January 2018

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Distinct Acidic Clusters and Hydrophobic Residues in the Alternative Splice Domains X1 and X2 of α7 Integrins Define Specificity for Laminin Isoforms

21 January 2018

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Probing Integrin Selectivity: Rational Design of Highly Active and Selective Ligands for the α5β1 and αvβ3 Integrin Receptor

21 January 2018

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Design and synthesis of a new class of selective integrin alpha5beta1 antagonists

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19747169

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The role of integrin alpha5beta1 in the regulation of corneal neovascularization

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19747169

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Modulation of ligand binding by alternative splicing of the alphaPS2 integrin subunit

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19747169

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1042/BJ20090992

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19747169%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19747169%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

1 reference