Understanding Programming of Fungal Iterative Polyketide Synthases: The Biochemical Basis for Regioselectivity by the Methyltransferase Domain in the Lovastatin Megasynthase. (Q41965309)

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scientific article published on 2 December 2015

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English	Understanding Programming of Fungal Iterative Polyketide Synthases: The Biochemical Basis for Regioselectivity by the Methyltransferase Domain in the Lovastatin Megasynthase.	scientific article published on 2 December 2015

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scholarly article

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1 March 2020

Understanding Programming of Fungal Iterative Polyketide Synthases: The Biochemical Basis for Regioselectivity by the Methyltransferase Domain in the Lovastatin Megasynthase (English)

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1 March 2020

John Christopher Vederas

7

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1 March 2020

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1 March 2020

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1 March 2020

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Ralph A Cacho

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1 March 2020

Justin Thuss

2

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1 March 2020

Wei Xu

3

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1 March 2020

Allison Nguyen

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1 March 2020

Yi Tang

8

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1 March 2020

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10 December 2015

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1 March 2020

Journal of the American Chemical Society

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1 March 2020

137

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1 March 2020

50

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1 March 2020

15688-15691

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1 March 2020

Methylation-dependent acyl transfer between polyketide synthase and nonribosomal peptide synthetase modules in fungal natural product biosynthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4906797

5 June 2018

Enediyne polyketide synthases stereoselectively reduce the β-ketoacyl intermediates to β-D-hydroxyacyl intermediates in enediyne core biosynthesis

1 reference

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5 June 2018

Assembly line polyketide synthases: mechanistic insights and unsolved problems

1 reference

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5 June 2018

Expanding the structural diversity of polyketides by exploring the cofactor tolerance of an inline methyltransferase domain

1 reference

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5 June 2018

Identification and characterization of the chaetoviridin and chaetomugilin gene cluster in Chaetomium globosum reveal dual functions of an iterative highly-reducing polyketide synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4906797

5 June 2018

Navigating the fungal polyketide chemical space: from genes to molecules.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4906797

5 June 2018

Crystal structure and biochemical studies of the trans-acting polyketide enoyl reductase LovC from lovastatin biosynthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4906797

5 June 2018

Rational domain swaps decipher programming in fungal highly reducing polyketide synthases and resurrect an extinct metabolite.

1 reference

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5 June 2018

Complete reconstitution of a highly reducing iterative polyketide synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4906797

5 June 2018

Acyltransferase mediated polyketide release from a fungal megasynthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4906797

5 June 2018

Probing the Interactions of early polyketide intermediates with the Actinorhodin ACP from S. coelicolor A3(2)

1 reference

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5 June 2018

Crystal Structure of the Erythromycin Polyketide Synthase Dehydratase

1 reference

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5 June 2018

Polyketides, proteins and genes in fungi: programmed nano-machines begin to reveal their secrets

1 reference

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5 June 2018

Biosynthesis of the 2-pyridone tenellin in the insect pathogenic fungus Beauveria bassiana.

1 reference

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5 June 2018

Structural mechanism for statin inhibition of HMG-CoA reductase

1 reference

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5 June 2018

Combinatorialization of fungal polyketide synthase-peptide synthetase hybrid proteins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4906797

18 August 2018

Production of novel fusarielins by ectopic activation of the polyketide synthase 9 cluster in Fusarium graminearum.

1 reference

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18 August 2018

Expression and kinetic analysis of the substrate specificity of modules 5 and 6 of the picromycin/methymycin polyketide synthase

1 reference

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18 August 2018

Assessing the balance between protein-protein interactions and enzyme-substrate interactions in the channeling of intermediates between polyketide synthase modules

1 reference

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18 August 2018

Employing modular polyketide synthase ketoreductases as biocatalysts in the preparative chemoenzymatic syntheses of diketide chiral building blocks

1 reference

https://pubmed.ncbi.nlm.nih.gov/26630357

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of Polyketide Synthase Activity by Accessory Proteins During Lovastatin Biosynthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/26630357

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JACS.5B11814

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Europe PubMed Central

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1 March 2020

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1 March 2020

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1 March 2020

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