Orexins protect neuronal cell cultures against hypoxic stress: an involvement of Akt signaling (Q41965823)

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1 March 2020

title

Orexins protect neuronal cell cultures against hypoxic stress: an involvement of Akt signaling (English)

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5

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Magdalena Namiecińska

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4

Waldemar Wagner

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7

Jolanta B Zawilska

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1 March 2020

author name string

Paulina Sokołowska

1

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Anna Urbańska

2

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Kaja Biegańska

3

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publication date

19 November 2013

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Journal of Molecular Neuroscience

1 March 2020

published in

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volume

52

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page(s)

48-55

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issue

1

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Creative Commons Attribution-NonCommercial 2.0 Generic

1 March 2020

copyright license

start time

19 November 2013

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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exact match

https://scigraph.springernature.com/pub.10.1007/s12031-013-0165-7

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cites work

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Agonist potency differentiates G protein activation and Ca2+ signalling by the orexin receptor type 1.

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G-protein-coupled OX1 orexin/hcrtr-1 hypocretin receptors induce caspase-dependent and -independent cell death through p38 mitogen-/stress-activated protein kinase

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OX1 orexin receptors couple to adenylyl cyclase regulation via multiple mechanisms

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Orexins acting at native OX(1) receptor in colon cancer and neuroblastoma cells or at recombinant OX(1) receptor suppress cell growth by inducing apoptosis.

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Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in mice

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5 June 2018

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Distribution of orexin neurons in the adult rat brain

5 June 2018

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

5 June 2018

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CREB is a regulatory target for the protein kinase Akt/PKB

5 June 2018

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Neurons containing hypocretin (orexin) project to multiple neuronal systems

5 June 2018

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Mitochondrial reactive oxygen species trigger hypoxia-induced transcription

5 June 2018

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5 June 2018

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5 June 2018

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Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

5 June 2018

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Orexins/hypocretins stimulate accumulation of inositol phosphate in primary cultures of rat cortical neurons

5 June 2018

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Activation of orexin/hypocretin type 1 receptors stimulates cAMP synthesis in primary cultures of rat astrocytes.

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The effect of orexin-A on the pathological mechanism in the rat focal cerebral ischemia.

18 August 2018

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Orexin neurons in the hypothalamus mediate cardiorespiratory responses induced by disinhibition of the amygdala and bed nucleus of the stria terminalis

18 August 2018

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Phosphorylation of huntingtin reduces the accumulation of its nuclear fragments

18 August 2018

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Effects of PACAP and VIP on cyclic AMP formation in rat neuronal and astrocyte cultures under normoxic and hypoxic condition.

18 August 2018

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Differential oxidative stress in oligodendrocytes and neurons after excitotoxic insults and protection by natural polyphenols.

18 August 2018

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Orexin inputs to caudal raphé neurons involved in thermal, cardiovascular, and gastrointestinal regulation.

18 August 2018

1 reference

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Hypocretin is an early member of the incretin gene family.

18 August 2018

1 reference

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Human pheochromocytomas express orexin receptor type 2 gene and display an in vitro secretory response to orexins A and B.

18 August 2018

1 reference

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Akt activation protects hippocampal neurons from apoptosis by inhibiting transcriptional activity of p53.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3929148

Serum-free B27/neurobasal medium supports differentiated growth of neurons from the striatum, substantia nigra, septum, cerebral cortex, cerebellum, and dentate gyrus

18 August 2018

1 reference

12 December 2020

Orexin-A inhibits glucagon secretion and gene expression through a Foxo1-dependent pathway

1 reference

12 December 2020

Neuroprotective effect of orexin-A is mediated by an increase of hypoxia-inducible factor-1 activity in rat

1 reference

12 December 2020

Orexins promote survival of rat cortical neurons

1 reference

12 December 2020

10.1007/S12031-013-0165-7

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1 March 2020

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1 March 2020

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