Metformin prevents and reverses inflammation in a non-diabetic mouse model of nonalcoholic steatohepatitis (Q41992046)

14 October 2017

Metformin prevents and reverses inflammation in a non-diabetic mouse model of nonalcoholic steatohepatitis (English)

1 reference

14 October 2017

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1 reference

Yuki Kita

1

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14 October 2017

Toshinari Takamura

2

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14 October 2017

Hirofumi Misu

3

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14 October 2017

Tsuguhito Ota

4

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14 October 2017

Seiichiro Kurita

5

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14 October 2017

Yumie Takeshita

6

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14 October 2017

Masafumi Uno

7

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14 October 2017

Naoto Matsuzawa-Nagata

8

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14 October 2017

Ken-Ichiro Kato

9

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14 October 2017

Hitoshi Ando

10

1 reference

14 October 2017

Akio Fujimura

11

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14 October 2017

Koji Hayashi

12

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14 October 2017

Toru Kimura

13

1 reference

14 October 2017

Yinhua Ni

14

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14 October 2017

Toshiki Otoda

15

1 reference

14 October 2017

Ken-ichi Miyamoto

16

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14 October 2017

Yoh Zen

17

1 reference

14 October 2017

Yasuni Nakanuma

18

1 reference

14 October 2017

Shuichi Kaneko

19

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14 October 2017

language of work or name

English

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publication date

18 September 2012

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14 October 2017

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14 October 2017

7

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14 October 2017

e43056

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14 October 2017

9

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Creative Commons Attribution 4.0 International

14 October 2017

start time

18 September 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis

5 June 2018

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Histological course of nonalcoholic fatty liver disease in Japanese patients: tight glycemic control, rather than weight reduction, ameliorates liver fibrosis

5 June 2018

1 reference

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Metformin suppresses glucose-6-phosphatase expression by a complex I inhibition and AMPK activation-independent mechanism

5 June 2018

1 reference

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Selective versus total insulin resistance: a pathogenic paradox

5 June 2018

1 reference

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High molecular weight adiponectin inhibits proliferation of hepatic stellate cells via activation of adenosine monophosphate-activated protein kinase

5 June 2018

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Cross talk of tumor necrosis factor-alpha and the renin-angiotensin system in tumor necrosis factor-alpha-induced plasminogen activator inhibitor-1 production from hepatocytes

5 June 2018

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Genes involved in oxidative phosphorylation are coordinately upregulated with fasting hyperglycaemia in livers of patients with type 2 diabetes.

5 June 2018

1 reference

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A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis

5 June 2018

1 reference

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Tumor necrosis factor-alpha-induced production of plasminogen activator inhibitor 1 and its regulation by pioglitazone and cerivastatin in a nonmalignant human hepatocyte cell line

5 June 2018

1 reference

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Metformin prevents alcohol-induced liver injury in the mouse: Critical role of plasminogen activator inhibitor-1

5 June 2018

1 reference

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The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

5 June 2018

1 reference

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Prevention of obesity and insulin resistance in mice lacking plasminogen activator inhibitor 1.

5 June 2018

1 reference

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Disorders of lung matrix remodeling

5 June 2018

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Tumor necrosis factor-alpha and troglitazone regulate plasminogen activator inhibitor type 1 production through extracellular signal-regulated kinase- and nuclear factor-kappaB-dependent pathways in cultured human umbilical vein endothelial cells

5 June 2018

1 reference

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Role of AMP-activated protein kinase in mechanism of metformin action

5 June 2018

1 reference

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Metformin reverses fatty liver disease in obese, leptin-deficient mice

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3445596

Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

5 June 2018

1 reference

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Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions

5 June 2018

1 reference

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Efficacy and metabolic effects of metformin and troglitazone in type II diabetes mellitus.

5 June 2018

1 reference

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Plasminogen activator inhibitor-1 synthesis in the human hepatoma cell line Hep G2. Metformin inhibits the stimulating effect of insulin

5 June 2018

1 reference

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Regulation of fatty acid synthase gene expression: an approach for reducing fat accumulation

5 June 2018

1 reference

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Analysis of hepatic genes involved in the metabolism of fatty acids and iron in nonalcoholic fatty liver disease

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3445596

Obesity upregulates genes involved in oxidative phosphorylation in livers of diabetic patients

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3445596

Randomized, placebo-controlled trial of pioglitazone in nondiabetic subjects with nonalcoholic steatohepatitis

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3445596

The effect of metformin treatment on VEGF and PAI-1 levels in obese type 2 diabetic patients.

18 August 2018

1 reference

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Adenosine monophosphate-activated protein kinase modulates the activated phenotype of hepatic stellate cells.

18 August 2018

1 reference

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Comparison of the effects of pioglitazone and metformin on hepatic and extra-hepatic insulin action in people with type 2 diabetes.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3445596

A randomized controlled trial of metformin versus vitamin E or prescriptive diet in nonalcoholic fatty liver disease

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3445596

Genes for systemic vascular complications are differentially expressed in the livers of type 2 diabetic patients.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3445596

Nonalcoholic fatty liver disease: a feature of the metabolic syndrome

18 August 2018

1 reference

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Association of nonalcoholic fatty liver disease with insulin resistance.

18 August 2018

1 reference

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Morphometric analysis of nonsclerosed Glomeruli size and connective tissue content during the aging process

18 August 2018

1 reference

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Global gene expression analysis in liver of obese diabetic db/db mice treated with metformin

2 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23028442

12 December 2020

inferred from PubMed ID database lookup

Loss of MMP 13 attenuates murine hepatic injury and fibrosis during cholestasis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23028442

12 December 2020

inferred from PubMed ID database lookup

Insulin resistance accelerates a dietary rat model of nonalcoholic steatohepatitis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23028442

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1371/JOURNAL.PONE.0043056

1 reference

release_o2f6fhnptfh45k5lu2c73stxpu

14 October 2017

0 references

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/o2f6fhnptfh45k5lu2c73stxpu

24 November 2022

mapped directly with Wikidata item

1 reference

14 October 2017

1 reference