Emi1 maintains genomic integrity during zebrafish embryogenesis and cooperates with p53 in tumor suppression. (Q42021753)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19704007%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

title

Emi1 maintains genomic integrity during zebrafish embryogenesis and cooperates with p53 in tumor suppression (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19704007%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

0 references

1 reference

GOA release 2020-03-11

1 reference

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19704007%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Alejandro Gutierrez

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19704007%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

3

Takaomi Sanda

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19704007%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

28

A Thomas Look

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19704007%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

author name string

Jennifer Rhodes

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19704007%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Adam Amsterdam

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19704007%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Lisa A Moreau

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19704007%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Keith McKenna

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19704007%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Stefan Heinrichs

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19704007%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Neil J Ganem

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19704007%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Karen W Ho

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19704007%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Donna S Neuberg

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19704007%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Adam Johnston

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19704007%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Yebin Ahn

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19704007%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Jeffery L Kutok

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19704007%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Robert Hromas

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19704007%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Justin Wray

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19704007%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Charles Lee

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19704007%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Carly Murphy

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19704007%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Ina Radtke

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19704007%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

James R Downing

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19704007%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Laura E MacConaill

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19704007%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

James F Amatruda

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19704007%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Ilene Galinsky

23

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19704007%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Richard M Stone

24

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19704007%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Eric A Ross

25

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19704007%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

David S Pellman

26

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19704007%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

John P Kanki

27

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19704007%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

language of work or name

English

0 references

publication date

24 August 2009

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19704007%20AND%20SRC:MED&resulttype=core&format=json

Molecular and Cellular Biology

6 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19704007%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

volume

29

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19704007%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

issue

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19704007%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

page(s)

5911-5922

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19704007%20AND%20SRC:MED&resulttype=core&format=json

Genomic analysis of the clonal origins of relapsed acute lymphoblastic leukemia.

6 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772726

DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772726

The SET and transposase domain protein Metnase enhances chromosome decatenation: regulation by automethylation

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772726

Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772726

Cell cycle progression is required for zebrafish somite morphogenesis but not segmentation clock function

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772726

Microdeletions are a general feature of adult and adolescent acute lymphoblastic leukemia: Unexpected similarities with pediatric disease

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772726

Specific tumor suppressor function for E2F2 in Myc-induced T cell lymphomagenesis

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772726

Loss of Emi1-dependent anaphase-promoting complex/cyclosome inhibition deregulates E2F target expression and elicits DNA damage-induced senescence.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772726

Effects of aneuploidy on cellular physiology and cell division in haploid yeast

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772726

Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772726

Emi1 is needed to couple DNA replication with mitosis but does not regulate activation of the mitotic APC/C

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772726

Oncogenic regulators and substrates of the anaphase promoting complex/cyclosome are frequently overexpressed in malignant tumors.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772726

The APC/C inhibitor, Emi1, is essential for prevention of rereplication

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772726

A mutation in separase causes genome instability and increased susceptibility to epithelial cancer

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772726

Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772726

Mouse emi1 has an essential function in mitotic progression during early embryogenesis

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772726

Coordinated requirements of human topo II and cohesin for metaphase centromere alignment under Mad2-dependent spindle checkpoint surveillance

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772726

tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772726

Interplay of pu.1 and gata1 determines myelo-erythroid progenitor cell fate in zebrafish

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772726

Inhibition of DNA decatenation, but not DNA damage, arrests cells at metaphase

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772726

Topoisomerase II and histone deacetylase inhibitors delay the G2/M transition by triggering the p38 MAPK checkpoint pathway

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772726

Identification of 315 genes essential for early zebrafish development

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772726

Evolution of clonal cytogenetic abnormalities in aplastic anemia

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772726

E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772726

Emi1 is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772726

Coincidence, coevolution, or causation? DNA content, cell size, and the C-value enigma

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772726

Allelic loss in the progression of myelodysplastic syndrome

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772726

A large-scale insertional mutagenesis screen in zebrafish

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772726

High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772726

Insertional mutagenesis and rapid cloning of essential genes in zebrafish.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772726

Stages of embryonic development of the zebrafish

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772726

Topoisomerase II inhibition prevents anaphase chromatid segregation in mammalian cells independently of the generation of DNA strand breaks.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772726

A topoisomerase II-dependent G2 cycle checkpoint in mammalian cells/.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772726

Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphomagenesis in E mu-myc transgenic mice.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772726

Emi1 protein accumulation implicates misregulation of the anaphase promoting complex/cyclosome pathway in ovarian clear cell carcinoma.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772726

Characterization of 6q abnormalities in childhood acute myeloid leukemia and identification of a novel t(6;11)(q24.1;p15.5) resulting in a NUP98-C6orf80 fusion in a case of acute megakaryoblastic leukemia.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772726

The pu.1 promoter drives myeloid gene expression in zebrafish.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772726

Insertional mutagenesis in zebrafish rapidly identifies genes essential for early vertebrate development

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772726

Molecular Pathogenesis of MDS

17 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19704007

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Inhibition of intracellular topoisomerase II by antitumor bis(2,6-dioxopiperazine) derivatives: mode of cell growth inhibition distinct from that of cleavable complex-forming type inhibitors

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19704007

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Role of DNA topoisomerase II in chromosome dynamics in mammalian cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19704007

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/MCB.00558-09

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19704007%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19704007%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

1 reference