A new Aspergillus fumigatus resistance mechanism conferring in vitro cross-resistance to azole antifungals involves a combination of cyp51A alterations. (Q42048818)

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scientific article published on 19 March 2007

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English	A new Aspergillus fumigatus resistance mechanism conferring in vitro cross-resistance to azole antifungals involves a combination of cyp51A alterations.	scientific article published on 19 March 2007

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scholarly article

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27 December 2019

A new Aspergillus fumigatus resistance mechanism conferring in vitro cross-resistance to azole antifungals involves a combination of cyp51A alterations (English)

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27 December 2019

Aspergillus fumigatus

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14-alpha sterol demethylase

1 reference

6 February 2019

Putative 14-alpha demethylase with a predicted role in ergosterol biosynthesis

1 reference

6 February 2019

1

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27 December 2019

Willem Melchers

4

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27 December 2019

Paul E. Verweij

5

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27 December 2019

author name string

G Garcia-Effron

2

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27 December 2019

L Alcázar-Fuoli

3

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27 December 2019

M Cuenca-Estrella

6

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27 December 2019

J L Rodríguez-Tudela

7

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publication date

19 March 2007

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27 December 2019

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8

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Antimicrobial Agents and Chemotherapy

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51

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27 December 2019

1897-1904

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6

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27 December 2019

Head-to-head comparison of the activities of currently available antifungal agents against 3,378 Spanish clinical isolates of yeasts and filamentous fungi.

1 reference

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Aspergillus fumigatus C-5 sterol desaturases Erg3A and Erg3B: role in sterol biosynthesis and antifungal drug susceptibility.

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1 reference

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Aspergillus fumigatus: saprophyte or pathogen?

1 reference

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Targeted gene disruption of the 14-alpha sterol demethylase (cyp51A) in Aspergillus fumigatus and its role in azole drug susceptibility.

1 reference

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In vitro evolution of itraconazole resistance in Aspergillus fumigatus involves multiple mechanisms of resistance

1 reference

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5 June 2018

Substitutions at methionine 220 in the 14alpha-sterol demethylase (Cyp51A) of Aspergillus fumigatus are responsible for resistance in vitro to azole antifungal drugs

1 reference

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Three-dimensional models of wild-type and mutated forms of cytochrome P450 14alpha-sterol demethylases from Aspergillus fumigatus and Candida albicans provide insights into posaconazole binding.

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Multiple resistance mechanisms among Aspergillus fumigatus mutants with high-level resistance to itraconazole.

1 reference

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A point mutation in the 14alpha-sterol demethylase gene cyp51A contributes to itraconazole resistance in Aspergillus fumigatus

1 reference

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Mutations in Aspergillus fumigatus resulting in reduced susceptibility to posaconazole appear to be restricted to a single amino acid in the cytochrome P450 14alpha-demethylase

1 reference

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Population genomics of drug resistance in Candida albicans.

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Invasive aspergillosis in 2002: an update

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Resistance of Candida species to antifungal agents: molecular mechanisms and clinical consequences

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Antifungal activities of posaconazole, ravuconazole, and voriconazole compared to those of itraconazole and amphotericin B against 239 clinical isolates of Aspergillus spp. and other filamentous fungi: report from SENTRY Antimicrobial Surveillance P

1 reference

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5 June 2018

Azole cross-resistance in Aspergillus fumigatus

1 reference

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5 June 2018

Identification of two different 14-alpha sterol demethylase-related genes (cyp51A and cyp51B) in Aspergillus fumigatus and other Aspergillus species

1 reference

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Resistance to itraconazole in Aspergillus nidulans and Aspergillus fumigatus is conferred by extra copies of the A. nidulans P-450 14alpha-demethylase gene, pdmA.

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Tandem repeat of a transcriptional enhancer upstream of the sterol 14alpha-demethylase gene (CYP51) in Penicillium digitatum

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Amino acid substitutions in the cytochrome P-450 lanosterol 14alpha-demethylase (CYP51A1) from azole-resistant Candida albicans clinical isolates contribute to resistance to azole antifungal agents

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The genetics of Aspergillus nidulans

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12 December 2020

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Reduced susceptibility in laboratory-selected mutants of Aspergillus fumigatus to itraconazole due to decreased intracellular accumulation of the antifungal agent

1 reference

https://pubmed.ncbi.nlm.nih.gov/17371828

12 December 2020

based on heuristic

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In vitro susceptibility of respiratory isolates of Aspergillus species to itraconazole and amphotericin B. acquired resistance to itraconazole

1 reference

https://pubmed.ncbi.nlm.nih.gov/17371828

12 December 2020

based on heuristic

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Multiple-Triazole–Resistant Aspergillosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17371828

12 December 2020

based on heuristic

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Identifiers

10.1128/AAC.01092-06

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27 December 2019

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27 December 2019

1 reference

Europe PubMed Central

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27 December 2019

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