Human cytosolic hydroxysteroid dehydrogenases of the aldo-ketoreductase superfamily catalyze reduction of conjugated steroids: implications for phase I and phase II steroid hormone metabolism. (Q42090716)

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scientific article published on 12 February 2009

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English	Human cytosolic hydroxysteroid dehydrogenases of the aldo-ketoreductase superfamily catalyze reduction of conjugated steroids: implications for phase I and phase II steroid hormone metabolism.	scientific article published on 12 February 2009

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scholarly article

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21 January 2020

Human cytosolic hydroxysteroid dehydrogenases of the aldo-ketoreductase superfamily catalyze reduction of conjugated steroids: implications for phase I and phase II steroid hormone metabolism (English)

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21 January 2020

5alpha-dihydrotestosterone sulfate(1-)

1 reference

ChEBI release 2020-05-28

(3beta,5alpha,17beta)-3-hydroxyandrostan-17-yl sulfate(1-)

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ChEBI release 2020-05-28

Trevor M Penning

6

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21 January 2020

author name string

Yi Jin

1

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21 January 2020

Ling Duan

2

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21 January 2020

Helenius J Kloosterboer

4

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Ian A Blair

5

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12 February 2009

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21 January 2020

Journal of Biological Chemistry

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21 January 2020

284

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21 January 2020

10013-10022

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Europe PubMed Central

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21 January 2020

Inactivation by UDP-glucuronosyltransferase enzymes: the end of androgen signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2665056

29 May 2018

Aldo-keto reductases and bioactivation/detoxication.

1 reference

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Vitamin D receptor regulation of the steroid/bile acid sulfotransferase SULT2A1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2665056

29 May 2018

Tibolone metabolism in human liver is catalyzed by 3alpha/3beta-hydroxysteroid dehydrogenase activities of the four isoforms of the aldo-keto reductase (AKR)1C subfamily

1 reference

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29 May 2018

Crystal structures of the multispecific 17beta-hydroxysteroid dehydrogenase type 5: critical androgen regulation in human peripheral tissues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2665056

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Crystal structures of prostaglandin D(2) 11-ketoreductase (AKR1C3) in complex with the nonsteroidal anti-inflammatory drugs flufenamic acid and indomethacin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2665056

29 May 2018

Crystal structure of human prostaglandin F synthase (AKR1C3)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2665056

29 May 2018

Human cytosolic 3alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily display significant 3beta-hydroxysteroid dehydrogenase activity: implications for steroid hormone metabolism and action

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2665056

29 May 2018

Inactivation of androgens by UDP-glucuronosyltransferase enzymes in humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2665056

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Human 20alpha-hydroxysteroid dehydrogenase: crystallographic and site-directed mutagenesis studies lead to the identification of an alternative binding site for C21-steroids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2665056

29 May 2018

Hydroxysteroid dehydrogenases and pre-receptor regulation of steroid hormone action.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2665056

29 May 2018

Human type 3 3alpha-hydroxysteroid dehydrogenase (aldo-keto reductase 1C2) and androgen metabolism in prostate cells.

1 reference

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An endocrine pathway in the prostate, ERbeta, AR, 5alpha-androstane-3beta,17beta-diol, and CYP7B1, regulates prostate growth

1 reference

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29 May 2018

Biochemical characterization and tissue distribution of human SULT2B1

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29 May 2018

Crystal structure of human type III 3alpha-hydroxysteroid dehydrogenase/bile acid binding protein complexed with NADP(+) and ursodeoxycholate

1 reference

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29 May 2018

Tibolone: a steroid with a tissue-specific mode of action

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Relative enzymatic activity, protein stability, and tissue distribution of human steroid-metabolizing UGT2B subfamily members

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29 May 2018

Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2665056

29 May 2018

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Metabolism of the lipid peroxidation product, 4-hydroxy-trans-2-nonenal, in isolated perfused rat heart

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2665056

29 May 2018

Expression and characterization of recombinant type 2 3 alpha-hydroxysteroid dehydrogenase (HSD) from human prostate: demonstration of bifunctional 3 alpha/17 beta-HSD activity and cellular distribution

1 reference

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29 May 2018

Steroid recognition and regulation of hormone action: crystal structure of testosterone and NADP+ bound to 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase

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Specificity of glucuronosyltransferase activity in the human cancer cell line LNCaP, evidence for the presence of at least two glucuronosyltransferase enzymes.

1 reference

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Androgen conjugates: physiology and clinical significance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2665056

29 May 2018

Steroid 5 alpha-reductase: two genes/two enzymes

1 reference

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Role of substrate inhibition kinetics in enzymatic chemical oscillations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2665056

29 May 2018

17-beta-hydroxysteroid dehydrogenase from human red blood cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2665056

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29 May 2018

Pharmacokinetic parameters of tibolone and metabolites in plasma, urine, feces, and bile from ovariectomized cynomolgus monkeys after a single dose or multiple doses of tibolone.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2665056

17 August 2018

Transcript profiling of the androgen signal in normal prostate, benign prostatic hyperplasia, and prostate cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2665056

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Molecular docking simulations of steroid substrates into human cytosolic hydroxysteroid dehydrogenases (AKR1C1 and AKR1C2): insights into positional and stereochemical preferences

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2665056

17 August 2018

Identification of the major oxidative 3alpha-hydroxysteroid dehydrogenase in human prostate that converts 5alpha-androstane-3alpha,17beta-diol to 5alpha-dihydrotestosterone: a potential therapeutic target for androgen-dependent disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2665056

17 August 2018

Tibolone is metabolized by the 3alpha/3beta-hydroxysteroid dehydrogenase activities of the four human isozymes of the aldo-keto reductase 1C subfamily: inversion of stereospecificity with a delta5(10)-3-ketosteroid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2665056

17 August 2018

Sulfation of tibolone and tibolone metabolites by expressed human cytosolic sulfotransferases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2665056

17 August 2018

The in vivo human metabolism of tibolone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2665056

17 August 2018

Expression and Characterization of Recombinant Type 2 3 -Hydroxysteroid Dehydrogenase (HSD) from Human Prostate: Demonstration of Bifunctional 3 /17 -HSD Activity and Cellular Distribution

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M809465200

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1 reference

https://pubmed.ncbi.nlm.nih.gov/19218247

12 December 2020

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Levels of tibolone and estradiol and their nonsulfated and sulfated metabolites in serum, myometrium, and vagina of postmenopausal women following treatment for 21 days with tibolone, estradiol, or estradiol plus medroxyprogestrone acetate

1 reference

https://pubmed.ncbi.nlm.nih.gov/19218247

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elucidation of a complete kinetic mechanism for a mammalian hydroxysteroid dehydrogenase (HSD) and identification of all enzyme forms on the reaction coordinate: the example of rat liver 3alpha-HSD (AKR1C9)

1 reference

https://pubmed.ncbi.nlm.nih.gov/19218247

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Androstanediol glucuronide isomers in normal men and women and in men infused with labeled dihydrotestosterone

1 reference

https://pubmed.ncbi.nlm.nih.gov/19218247

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetic parameters of sulfated tibolone metabolites in postmenopausal women after single and multiple doses of tibolone

1 reference

https://pubmed.ncbi.nlm.nih.gov/19218247

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression and characterization of four recombinant human dihydrodiol dehydrogenase isoforms: oxidation of trans-7, 8-dihydroxy-7,8-dihydrobenzo

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetic and structural characterization of the glutathione-binding site of aldose reductase

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The arginine 276 anchor for NADP(H) dictates fluorescence kinetic transients in 3 alpha-hydroxysteroid dehydrogenase, a representative aldo-keto reductase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19218247

12 December 2020

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Levels of plasma C19 steroids and 5 alpha-reduced C19 steroid glucuronides in primates, rodents, and domestic animals

1 reference

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based on heuristic

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Identifiers

10.1074/JBC.M809465200

1 reference

Europe PubMed Central

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21 January 2020

1 reference

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21 January 2020

1 reference

Europe PubMed Central

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21 January 2020

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