Breaking free of sample size dogma to perform innovative translational research (Q42117164)

16 October 2017

Breaking free of sample size dogma to perform innovative translational research (English)

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16 October 2017

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2

Steven G Deeks

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16 October 2017

Peter Bacchetti

1

1 reference

16 October 2017

Joseph M McCune

series ordinal

3

1 reference

16 October 2017

language of work or name

English

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publication date

1 June 2011

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Science Translational Medicine

16 October 2017

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16 October 2017

3

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16 October 2017

87

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16 October 2017

87ps24

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Evidence for the cure of HIV infection by CCR5Δ32/Δ32 stem cell transplantation

16 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134305

IL-22+ CD4+ T cells are associated with therapeutic trichuris trichiura infection in an ulcerative colitis patient.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134305

The null hypothesis significance test in health sciences research (1995-2006): statistical analysis and interpretation

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134305

Pancreatic Extracts in the Treatment of Diabetes Mellitus

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134305

Current sample size conventions: flaws, harms, and alternatives

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134305

Linking scientific discovery and better health for the nation: the first three years of the NIH's Clinical and Translational Science Awards

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134305

Optimal sample size determinations from an industry perspective based on the expected value of information

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134305

Simple, defensible sample sizes based on cost efficiency

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134305

In the era of systematic reviews, does the size of an individual trial still matter

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134305

Caution regarding the use of pilot studies to guide power calculations for study proposals

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134305

Peer review of statistics in medical research: the other problem

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134305

Toward evidence-based medical statistics. 1: The P value fallacy

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134305

The myth of the medical breakthrough: smallpox, vaccination, and Jenner reconsidered

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134305

The use of predicted confidence intervals when planning experiments and the misuse of power when interpreting results.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134305

Small clinical trials: are they all bad?

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134305

Confidence intervals rather than P values: estimation rather than hypothesis testing

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134305

Using cost-effectiveness analysis to improve the efficiency of allocating funds to clinical trials.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134305

No adjustments are needed for multiple comparisons

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134305

Sample size calculations in randomised trials: mandatory and mystical

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134305

The value of information and optimal clinical trial design.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134305

17 August 2018

Ethics and sample size

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134305

The continuing unethical conduct of underpowered clinical trials.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134305

Significance tests harm progress in forecasting

17 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3001628

The earth is round (p < .05).

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3001628

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3001628

Why most published research findings are false

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3001628

The discovery of insulin: the Rochester, New York, connection

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21677197

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Adding nails to the coffin of underpowered trials

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21677197

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1126/SCITRANSLMED.3001628

1 reference

16 October 2017

1 reference

16 October 2017

PubMed publication ID

21677197

1 reference