Protein interaction switches coordinate Raf-1 and MST2/Hippo signalling (Q42152409)

17 October 2017

Protein interaction switches coordinate Raf-1 and MST2/Hippo signalling (English)

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Melinda Halasz

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author name string

David Romano

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1

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PubMed ID

24929361

17 October 2017

Carolanne Doherty

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17 October 2017

15 June 2014

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17 October 2017

673-684

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https://scigraph.springernature.com/pub.10.1038/ncb2986

17 October 2017

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cites work

Regulation of Raf-1 activation and signalling by dephosphorylation

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12 December 2020

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

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12 December 2020

Mutant K-Ras activation of the proapoptotic MST2 pathway is antagonized by wild-type K-Ras.

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12 December 2020

Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras

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12 December 2020

Dephosphorylation of Ser-259 regulates Raf-1 membrane association

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12 December 2020

Bistability and oscillations in the Huang-Ferrell model of MAPK signaling

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12 December 2020

Molecular and clinical analysis of RAF1 in Noonan syndrome and related disorders: dephosphorylation of serine 259 as the essential mechanism for mutant activation

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12 December 2020

The mammalian MAPK/ERK pathway exhibits properties of a negative feedback amplifier

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12 December 2020

Competition effects shape the response sensitivity and kinetics of phosphorylation cycles in cell signaling

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12 December 2020

RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor protein

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12 December 2020

Signaling switches and bistability arising from multisite phosphorylation in protein kinase cascades

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12 December 2020

Signalling ballet in space and time

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12 December 2020

Induction of apoptosis in fibroblasts by c-myc protein

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12 December 2020

Substrate competition as a source of ultrasensitivity in the inactivation of Wee1.

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12 December 2020

Numerical modelling of label-structured cell population growth using CFSE distribution data

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12 December 2020

Cyclic AMP-dependent kinase regulates Raf-1 kinase mainly by phosphorylation of serine 259.

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12 December 2020

Rassf family of tumor suppressor polypeptides.

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12 December 2020

Cell-signalling dynamics in time and space

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12 December 2020

Protein kinases of the Hippo pathway: regulation and substrates

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12 December 2020

Mapping of MST1 kinase sites of phosphorylation. Activation and autophosphorylation

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12 December 2020

Protein kinase A blocks Raf-1 activity by stimulating 14-3-3 binding and blocking Raf-1 interaction with Ras.

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12 December 2020

The RASSF proteins in cancer; from epigenetic silencing to functional characterization

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12 December 2020

Simplistic pathways or complex networks?

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12 December 2020

Cell fate decisions are specified by the dynamic ERK interactome

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12 December 2020

Hippo signaling: growth control and beyond

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12 December 2020

Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1.

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12 December 2020

The tumor suppressor RASSF1A prevents dephosphorylation of the mammalian STE20-like kinases MST1 and MST2.

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12 December 2020

Regulation of Raf-1 and Raf-1 mutants by Ras-dependent and Ras-independent mechanisms in vitro

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12 December 2020

Proapoptotic kinase MST2 coordinates signaling crosstalk between RASSF1A, Raf-1, and Akt

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12 December 2020

The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1

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12 December 2020

Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras

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12 December 2020

Molecular interpretation of ERK signal duration by immediate early gene products

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12 December 2020

The biochemical basis of an all-or-none cell fate switch in Xenopus oocytes

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12 December 2020

Protein phosphatases 1 and 2A promote Raf-1 activation by regulating 14-3-3 interactions

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12 December 2020

Ligand-specific c-Fos expression emerges from the spatiotemporal control of ErbB network dynamics

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12 December 2020

Establishment of transgenic lines to monitor and manipulate Yap/Taz-Tead activity in zebrafish reveals both evolutionarily conserved and divergent functions of the Hippo pathway

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12 December 2020

Hysteresis drives cell-cycle transitions in Xenopus laevis egg extracts

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12 December 2020

LATS tumor suppressor: a new governor of cellular homeostasis

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12 December 2020

Phosphatase and feedback regulation of Raf-1 signaling

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12 December 2020

Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy

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12 December 2020

Regulation of Raf-1 by direct feedback phosphorylation.

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12 December 2020

The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1

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12 December 2020

Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis

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12 December 2020

Comparative proteomic analysis of eleven common cell lines reveals ubiquitous but varying expression of most proteins

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12 December 2020

Raf-1 regulates Rho signaling and cell migration

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12 December 2020

An evolutionary shift in the regulation of the Hippo pathway between mice and flies

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12 December 2020

Signal control through Raf: in sickness and in health

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12 December 2020

Raf family kinases: old dogs have learned new tricks

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12 December 2020

Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK-ERK independent mechanism

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12 December 2020

Multiple Ras functions can contribute to mammalian cell transformation

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12 December 2020

ATM regulates a RASSF1A-dependent DNA damage response

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12 December 2020

Germline gain-of-function mutations in RAF1 cause Noonan syndrome

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12 December 2020

A Raf-1 mutant that dissociates MEK/extracellular signal-regulated kinase activation from malignant transformation and differentiation but not proliferation.

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12 December 2020

Biochemical analysis of MST1 kinase: elucidation of a C-terminal regulatory region

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12 December 2020

Identifiers

DOI

10.1038/NCB2986

1 reference

PubMed ID

24929361

Dimensions Publication ID

17 October 2017

0 references

1 reference

PubMed ID

24929361