Measuring human beta-secretase (BACE1) activity using homogeneous time-resolved fluorescence (Q42166896)

17 October 2017

title

Measuring human beta-secretase (BACE1) activity using homogeneous time-resolved fluorescence (English)

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17 October 2017

Matthew E Kennedy

1

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17 October 2017

Wenyan Wang

2

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17 October 2017

Lixin Song

3

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17 October 2017

Julie Lee

4

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17 October 2017

Lili Zhang

5

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17 October 2017

Gwen Wong

6

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17 October 2017

Liyang Wang

7

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17 October 2017

Eric Parker

8

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17 October 2017

language of work or name

English

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publication date

1 August 2003

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17 October 2017

published in

Analytical Biochemistry

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17 October 2017

volume

319

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17 October 2017

issue

1

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17 October 2017

page(s)

49-55

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Alzheimer's disease: genes, proteins, and therapy

17 October 2017

cites work

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The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway

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Purification and cloning of amyloid precursor protein beta-secretase from human brain

7 January 2021

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

7 January 2021

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Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

7 January 2021

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ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site

7 January 2021

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BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

7 January 2021

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Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

7 January 2021

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BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

7 January 2021

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Characterization of recombinant, soluble beta-secretase from an insect cell expression system.

7 January 2021

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Novel fluorogenic substrates for assaying retroviral proteases by resonance energy transfer

7 January 2021

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A continuous fluorescence assay of renin activity

7 January 2021

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7 January 2021

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Allophycocyanin 1 as a near-infrared fluorescent tracer: isolation, characterization, chemical modification, and use in a homogeneous fluorescence resonance energy transfer system

7 January 2021

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Proteolytic activation of recombinant pro-memapsin 2 (pro-beta-secretase) studied with new fluorogenic substrates

7 January 2021

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Structure-based design: potent inhibitors of human brain memapsin 2 (beta-secretase).

7 January 2021

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Crystal structure of memapsin 2 (beta-secretase) in complex with an inhibitor OM00-3

7 January 2021

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The pro domain of beta-secretase does not confer strict zymogen-like properties but does assist proper folding of the protease domain

7 January 2021

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Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor

7 January 2021

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Substrate and inhibitor profile of BACE (beta-secretase) and comparison with other mammalian aspartic proteases

7 January 2021

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Recombinant insect cell expression and purification of human beta-secretase (BACE-1) for X-ray crystallography

7 January 2021

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10.1016/S0003-2697(03)00253-7

7 January 2021

Identifiers

DOI

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17 October 2017

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