Conjugation site heterogeneity causes variable electrostatic properties in Fc conjugates. (Q42174344)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23777335%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

title

Conjugation site heterogeneity causes variable electrostatic properties in Fc conjugates (English)

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3 March 2020

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6

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3 March 2020

author name string

Nicholas J Boylan

1

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3 March 2020

Wen Zhou

2

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3 March 2020

Robert J Proos

3

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3 March 2020

Thomas J Tolbert

4

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3 March 2020

Janet L Wolfe

5

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3 March 2020

publication date

31 May 2013

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3 March 2020

published in

Bioconjugate Chemistry

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3 March 2020

volume

24

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3 March 2020

issue

6

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3 March 2020

page(s)

1008-1016

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Impact of linker and conjugation chemistry on antigen binding, Fc receptor binding and thermal stability of model antibody-drug conjugates

3 March 2020

cites work

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26 October 2017

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26 October 2017

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Carboxyl pK(a) values, ion pairs, hydrogen bonding, and the pH-dependence of folding the hyperthermophile proteins Sac7d and Sso7d

26 October 2017

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Effects of protein aggregates: an immunologic perspective

26 October 2017

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Formulation considerations for proteins susceptible to asparagine deamidation and aspartate isomerization.

26 October 2017

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Structural characterization of the maytansinoid-monoclonal antibody immunoconjugate, huN901-DM1, by mass spectrometry

26 October 2017

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Cloning and disruption of the PpURA5 gene and construction of a set of integration vectors for the stable genetic modification of Pichia pastoris

26 October 2017

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Crystal structure of a neutralizing human IGG against HIV-1: a template for vaccine design

26 October 2017

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Electrostatic strengths of salt bridges in thermophilic and mesophilic glutamate dehydrogenase monomers.

26 October 2017

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Analysis of monoclonal antibody and immunoconjugate digests by capillary electrophoresis and capillary liquid chromatography

26 October 2017

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The influence of charge distribution on self-association and viscosity behavior of monoclonal antibody solutions

26 October 2017

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Impact of drug conjugation on pharmacokinetics and tissue distribution of anti-STEAP1 antibody-drug conjugates in rats

17 August 2018

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Identification of amino acid residues responsible for the release of free drug from an antibody-drug conjugate utilizing lysine-succinimidyl ester chemistry

17 August 2018

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Physicochemical stability of the antibody-drug conjugate Trastuzumab-DM1: changes due to modification and conjugation processes

17 August 2018

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Structure and stability changes of human IgG1 Fc as a consequence of methionine oxidation.

17 August 2018

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Engineered antibody-drug conjugates with defined sites and stoichiometries of drug attachment.

17 August 2018

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Analysis of the composition of immunoconjugates using size-exclusion chromatography coupled to mass spectrometry

17 August 2018

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An electrostatic basis for the stability of thermophilic proteins

17 August 2018

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17 August 2018

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17 August 2018

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12 December 2020

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12 December 2020

Antineoplastic efficacy of doxorubicin enzymatically assembled on galactose residues of a monoclonal antibody specific for the carcinoembryonic antigen

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12 December 2020

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Charge heterogeneity of a therapeutic monoclonal antibody conjugated with a cytotoxic antitumor antibiotic, calicheamicin

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Identifiers

DOI

10.1021/BC4000564

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23777335%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23777335%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

1 reference