Accumulation of extracellular hyaluronan by hyaluronan synthase 3 promotes tumor growth and modulates the pancreatic cancer microenvironment. (Q42181013)

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scientific article published on 24 July 2014

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English	Accumulation of extracellular hyaluronan by hyaluronan synthase 3 promotes tumor growth and modulates the pancreatic cancer microenvironment.	scientific article published on 24 July 2014

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13 March 2020

Accumulation of extracellular hyaluronan by hyaluronan synthase 3 promotes tumor growth and modulates the pancreatic cancer microenvironment (English)

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pancreatic cancer

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Susan Zimmerman

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David A Tuveson

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Chunmei Zhao

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Netai C Singha

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Ryan J Osgood

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Rebecca Symons

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Ping Jiang

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Xiaoming Li

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Curtis B Thompson

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Jeffrey R Infante

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Michael A Jacobetz

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Gregory I Frost

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H Michael Shepard

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Zhongdong Huang

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24 July 2014

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BioMed Research International

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2014

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817613

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1 January 2014

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Prognostic impact of hyaluronan and its regulators in pancreatic ductal adenocarcinoma

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26 October 2017

Therapeutic targeting of hyaluronan in the tumor stroma

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26 October 2017

Deregulation of hyaluronan synthesis, degradation and binding promotes breast cancer

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26 October 2017

Hedgehog signaling regulates hypoxia induced epithelial to mesenchymal transition and invasion in pancreatic cancer cells via a ligand-independent manner

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26 October 2017

KIAA1199, a deafness gene of unknown function, is a new hyaluronan binding protein involved in hyaluronan depolymerization

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26 October 2017

Hypoxia induces epithelial-mesenchymal transition via activation of SNAI1 by hypoxia-inducible factor -1α in hepatocellular carcinoma

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26 October 2017

Hyaluronan, fluid pressure, and stromal resistance in pancreas cancer.

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26 October 2017

Efficient TGFβ-induced epithelial-mesenchymal transition depends on hyaluronan synthase HAS2.

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26 October 2017

Hydration dynamics of hyaluronan and dextran

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26 October 2017

Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer

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26 October 2017

Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma

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26 October 2017

HAS3-induced accumulation of hyaluronan in 3D MDCK cultures results in mitotic spindle misorientation and disturbed organization of epithelium.

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26 October 2017

Hyaluronan synthase HAS2 promotes tumor progression in bone by stimulating the interaction of breast cancer stem-like cells with macrophages and stromal cells

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26 October 2017

Inhibition of hyaluronan synthase-3 decreases subcutaneous colon cancer growth by increasing apoptosis

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26 October 2017

Inhibition of oesophageal squamous cell carcinoma progression by in vivo targeting of hyaluronan synthesis.

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26 October 2017

Inhibition of hyaluronan synthesis in breast cancer cells by 4-methylumbelliferone suppresses tumorigenicity in vitro and metastatic lesions of bone in vivo

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26 October 2017

Transcriptional and post-translational regulation of hyaluronan synthesis.

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26 October 2017

Hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in the accumulation of hyaluronan in endometrioid endometrial carcinoma

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26 October 2017

The activity of hyaluronan synthase 2 is regulated by dimerization and ubiquitination

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26 October 2017

Hyaluronan-CD44 Interactions in Cancer: Paradoxes and Possibilities

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26 October 2017

The basics of epithelial-mesenchymal transition

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26 October 2017

Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

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26 October 2017

Hyaluronidases in cancer biology

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26 October 2017

Hyaluronan in human tumors: pathobiological and prognostic messages from cell-associated and stromal hyaluronan

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26 October 2017

Hyaluronan constitutively regulates activation of COX-2-mediated cell survival activity in intestinal epithelial and colon carcinoma cells

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26 October 2017

Significance of tumor-associated stroma in promotion of intratumoral lymphangiogenesis: pivotal role of a hyaluronan-rich tumor microenvironment

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26 October 2017

The many ways to cleave hyaluronan.

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26 October 2017

Involvement of hyaluronan in regulation of fibroblast phenotype.

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26 October 2017

Tumor-stroma interactions in pancreatic ductal adenocarcinoma

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26 October 2017

Inhibitory effect of 4-methylesculetin on hyaluronan synthesis slows the development of human pancreatic cancer in vitro and in nude mice

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26 October 2017

Hyperproduction of hyaluronan in neu-induced mammary tumor accelerates angiogenesis through stromal cell recruitment: possible involvement of versican/PG-M.

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26 October 2017

Hyaluronan synthesis induces microvillus-like cell surface protrusions

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26 October 2017

Hypoxia-induced alterations in hyaluronan and hyaluronidase

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26 October 2017

The over-expression of HAS2, Hyal-2 and CD44 is implicated in the invasiveness of breast cancer

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26 October 2017

Antisense-mediated suppression of hyaluronan synthase 2 inhibits the tumorigenesis and progression of breast cancer.

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26 October 2017

Antisense inhibition of hyaluronan synthase-2 in human osteosarcoma cells inhibits hyaluronan retention and tumorigenicity

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26 October 2017

Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice

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26 October 2017

A hyaluronan synthase suppressor, 4-methylumbelliferone, inhibits liver metastasis of melanoma cells

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26 October 2017

Intracellular hyaluronan: a new frontier for inflammation?

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26 October 2017

Hyaluronan: from extracellular glue to pericellular cue.

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26 October 2017

Epithelial-cadherin and beta-catenin expression changes in pancreatic intraepithelial neoplasia

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26 October 2017

Keratinocyte Growth Factor Stimulates Migration and Hyaluronan Synthesis in the Epidermis by Activation of Keratinocyte Hyaluronan Synthases 2 and 3

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26 October 2017

Targeting HIF-1 for cancer therapy

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26 October 2017

Elevated hyaluronan production induces mesenchymal and transformed properties in epithelial cells

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26 October 2017

Inhibition of prostate tumor cell hyaluronan synthesis impairs subcutaneous growth and vascularization in immunocompromised mice

1 reference

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26 October 2017

Hyaluronan enters keratinocytes by a novel endocytic route for catabolism

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26 October 2017

Hyaluronan synthase 3 overexpression promotes the growth of TSU prostate cancer cells.

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26 October 2017

Epidermal growth factor activates hyaluronan synthase 2 in epidermal keratinocytes and increases pericellular and intracellular hyaluronan

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26 October 2017

Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchyme

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26 October 2017

Three isoforms of mammalian hyaluronan synthases have distinct enzymatic properties

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26 October 2017

Molecular cloning and characterization of a cDNA encoding the third putative mammalian hyaluronan synthase

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26 October 2017

Hyaluronan production enhances shedding of plasma membrane-derived microvesicles

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29 May 2018

Enzymatic depletion of tumor hyaluronan induces antitumor responses in preclinical animal models

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29 May 2018

Hyaluronan synthase 1 (HAS1) requires higher cellular UDP-GlcNAc concentration than HAS2 and HAS3.

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17 August 2018

Effective targeting of the tumor microenvironment for cancer therapy.

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17 August 2018

Mitotic spindle misorientation in cancer--out of alignment and into the fire.

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17 August 2018

Hyperglycemia, intracellular hyaluronan synthesis, cyclin D3 and autophagy.

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17 August 2018

Increased hyaluronan production and decreased E-cadherin expression by cytokine-stimulated keratinocytes lead to spongiosis formation.

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17 August 2018

Synthetic extracellular matrix enhances tumor growth and metastasis in an orthotopic mouse model of pancreatic adenocarcinoma.

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17 August 2018

Overexpression of hyaluronan synthases alters vascular smooth muscle cell phenotype and promotes monocyte adhesion

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17 August 2018

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10.1155/2014/817613

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