A novel strategy for inducing the antitumor effects of triterpenoid compounds: blocking the protumoral functions of tumor-associated macrophages via STAT3 inhibition (Q42181486)

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English	A novel strategy for inducing the antitumor effects of triterpenoid compounds: blocking the protumoral functions of tumor-associated macrophages via STAT3 inhibition	scientific article

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scholarly article

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Europe PubMed Central

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18 October 2017

6 references

12 October 2019

18 October 2019

7 November 2019

20 November 2019

28 November 2019

22 December 2019

A novel strategy for inducing the antitumor effects of triterpenoid compounds: blocking the protumoral functions of tumor-associated macrophages via STAT3 inhibition (English)

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Europe PubMed Central

PMC publication ID

18 October 2017

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12 October 2019

hemic and immune systems

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18 October 2019

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7 November 2019

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20 November 2019

transport protein

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28 November 2019

transcription factor

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22 December 2019

1

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24738052%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

Motohiro Takeya

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24738052%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

author name string

Yoshihiro Komohara

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24738052%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

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11 March 2014

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Europe PubMed Central

PMC publication ID

18 October 2017

12 October 2019

18 October 2019

7 November 2019

20 November 2019

28 November 2019

22 December 2019

BioMed Research International

7 references

12 October 2019

18 October 2019

7 November 2019

20 November 2019

28 November 2019

22 December 2019

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24738052%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

2014

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24738052%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

348539

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24738052%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

copyright license

Creative Commons Attribution 3.0 Unported

6 references

Europe PubMed Central

12 October 2019

Europe PubMed Central

18 October 2019

Europe PubMed Central

7 November 2019

Europe PubMed Central

20 November 2019

Europe PubMed Central

28 November 2019

Europe PubMed Central

22 December 2019

copyright status

0 references

Clinical significance of macrophage heterogeneity in human malignant tumors

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Clinical significance of CD163⁺ tumor-associated macrophages in patients with adult T-cell leukemia/lymphoma

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26 October 2017

Ursolic acid inhibits epithelial-mesenchymal transition by suppressing the expression of astrocyte-elevated gene-1 in human nonsmall cell lung cancer A549 cells.

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26 October 2017

Corosolic acid impairs tumor development and lung metastasis by inhibiting the immunosuppressive activity of myeloid-derived suppressor cells

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26 October 2017

Inhibitory effect of oleanolic acid on hepatocellular carcinoma via ERK-p53-mediated cell cycle arrest and mitochondrial-dependent apoptosis

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26 October 2017

In vitro anti-breast cancer activity of ethanolic extract of Wrightia tomentosa: role of pro-apoptotic effects of oleanolic acid and urosolic acid.

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26 October 2017

Ursolic acid inhibits growth and induces apoptosis in gemcitabine-resistant human pancreatic cancer via the JNK and PI3K/Akt/NF-κB pathways

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26 October 2017

Coordinated regulation of myeloid cells by tumours

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26 October 2017

Tumour macrophages as potential targets of bisphosphonates.

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26 October 2017

Ursolic acid induces apoptosis in human leukaemia cells and exhibits anti-leukaemic activity in nude mice through the PKB pathway

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26 October 2017

Oleanolic acid inhibits macrophage differentiation into the M2 phenotype and glioblastoma cell proliferation by suppressing the activation of STAT3.

1 reference

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26 October 2017

Characteristics of the alternative phenotype of microglia/macrophages and its modulation in experimental gliomas

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26 October 2017

Metchnikoff's policemen: macrophages in development, homeostasis and regeneration

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26 October 2017

Ursolic acid inhibits proliferation and induces apoptosis of cancer cells in vitro and in vivo

1 reference

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26 October 2017

Macrophage infiltration and its prognostic relevance in clear cell renal cell carcinoma.

1 reference

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26 October 2017

Ursolic acid induces apoptosis by suppressing the expression of FoxM1 in MCF-7 human breast cancer cells

1 reference

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26 October 2017

Corosolic acid inhibits glioblastoma cell proliferation by suppressing the activation of signal transducer and activator of transcription‐3 and nuclear factor‐kappa B in tumor cells and tumor‐associated macrophages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3967493

26 October 2017

Molecular mechanisms regulating myeloid-derived suppressor cell differentiation and function

1 reference

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26 October 2017

Activation of AMP-activated protein kinase on human gastric cancer cells by apoptosis induced by corosolic acid isolated from Weigela subsessilis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3967493

26 October 2017

Significance of alternatively activated macrophages in patients with intrahepatic cholangiocarcinoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3967493

26 October 2017

Down-regulation of human epidermal growth factor receptor 2/neu oncogene by corosolic acid induces cell cycle arrest and apoptosis in NCI-N87 human gastric cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3967493

26 October 2017

Oleanolic acid and ursolic acid induce apoptosis in HuH7 human hepatocellular carcinoma cells through a mitochondrial-dependent pathway and downregulation of XIAP.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3967493

26 October 2017

Antitumor and anti-inflammatory effects of trabectedin on human myxoid liposarcoma cells.

1 reference

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26 October 2017

Cucurbitacin B induces apoptosis by inhibition of the JAK/STAT pathway and potentiates antiproliferative effects of gemcitabine on pancreatic cancer cells

1 reference

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26 October 2017

Trophic macrophages in development and disease

1 reference

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26 October 2017

Microenvironmental regulation of metastasis

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26 October 2017

Regulation of macrophage function in tumors: the multifaceted role of NF-kappaB.

1 reference

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26 October 2017

The macrophage scavenger receptor CD163 functions as an innate immune sensor for bacteria

1 reference

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26 October 2017

Possible involvement of the M2 anti-inflammatory macrophage phenotype in growth of human gliomas.

1 reference

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26 October 2017

Macrophage polarization in tumour progression

1 reference

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26 October 2017

A previously unrecognized protein-protein interaction between TWEAK and CD163: potential biological implications

1 reference

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26 October 2017

CD163 expression confers susceptibility to porcine reproductive and respiratory syndrome viruses

1 reference

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26 October 2017

Altered macrophage differentiation and immune dysfunction in tumor development

1 reference

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The macrophage CD163 surface glycoprotein is an erythroblast adhesion receptor

1 reference

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Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment.

1 reference

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26 October 2017

Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: new molecules and patterns of gene expression

1 reference

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26 October 2017

Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: potential targets of anti-cancer therapy

1 reference

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26 October 2017

Distinct role of macrophages in different tumor microenvironments

1 reference

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26 October 2017

Small molecules that reactivate p53 in renal cell carcinoma reveal a NF-kappaB-dependent mechanism of p53 suppression in tumors

1 reference

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26 October 2017

Targeting Stat3 in cancer therapy

1 reference

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26 October 2017

The chemokine system in diverse forms of macrophage activation and polarization

1 reference

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26 October 2017

Ursolic acid induces apoptosis through mitochondrial intrinsic pathway and caspase-3 activation in M4Beu melanoma cells.

1 reference

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26 October 2017

Tumor-associated macrophages and dendritic cells as prototypic type II polarized myeloid populations

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Tumour-educated macrophages promote tumour progression and metastasis

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26 October 2017

The many faces of macrophage activation

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26 October 2017

Alternative activation of macrophages

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26 October 2017

Identification of the haemoglobin scavenger receptor.

1 reference

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26 October 2017

Other functions, other genes: alternative activation of antigen-presenting cells

1 reference

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26 October 2017

Ursolic acid inhibits the growth of colon cancer-initiating cells by targeting STAT3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3967493

17 August 2018

Corosolic acid induces apoptosis through mitochondrial pathway and caspase activation in human cervix adenocarcinoma HeLa cells.

1 reference

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17 August 2018

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1 reference

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17 August 2018

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1 reference

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17 August 2018

Aberrant inflammation and lethality to septic peritonitis in mice lacking STAT3 in macrophages and neutrophils.

1 reference

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17 August 2018

Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils.

1 reference

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17 August 2018

Hemoglobin scavenger receptor CD163 mediates interleukin-10 release and heme oxygenase-1 synthesis: antiinflammatory monocyte-macrophage responses in vitro, in resolving skin blisters in vivo, and after cardiopulmonary bypass surgery

1 reference

https://pubmed.ncbi.nlm.nih.gov/24738052

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AM-3K, an anti-macrophage antibody, recognizes CD163, a molecule associated with an anti-inflammatory macrophage phenotype

1 reference

https://pubmed.ncbi.nlm.nih.gov/24738052

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prognostic implication of types of tumor-associated macrophages in Hodgkin lymphoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/24738052

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determination of corosolic acid, a natural potential anti-diabetes compound, in rat plasma by high-performance liquid chromatography-mass spectrometry and its application to pharmacokinetic and bioavailability studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/24738052

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1155/2014/348539

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24738052%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

release_bicwyxnj2jf2np4qvl757hvihm

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https://api.fatcat.wiki/v0/release/bicwyxnj2jf2np4qvl757hvihm

24 November 2022

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mapped directly with Wikidata item

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24738052%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24738052%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

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