Divalent metals and pH alter raltegravir disposition in vitro (Q42189797)

18 October 2017

Divalent metals and pH alter raltegravir disposition in vitro (English)

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18 October 2017

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1

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7

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18 October 2017

Marco Siccardi

2

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author name string

Matthew Murphy

3

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18 October 2017

Michael M Piperakis

4

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18 October 2017

Saye H Khoo

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18 October 2017

David J Back

6

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18 October 2017

language of work or name

English

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publication date

26 March 2012

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18 October 2017

7

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Antimicrobial Agents and Chemotherapy

inferred from page(s)

published in

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18 October 2017

56

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18 October 2017

6

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18 October 2017

3020-3026

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Effect of food on the pharmacokinetics of the integrase inhibitor dolutegravir

18 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370743

Clinical pharmacokinetic and pharmacodynamic profile of the HIV integrase inhibitor elvitegravir

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370743

Clinical pharmacology profile of raltegravir, an HIV-1 integrase strand transfer inhibitor

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370743

Raltegravir is a substrate for SLC22A6: a putative mechanism for the interaction between raltegravir and tenofovir

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370743

Effect of antacids on the pharmacokinetics of raltegravir in human immunodeficiency virus-seronegative volunteers

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370743

Raltegravir: The evidence of its therapeutic value in HIV-1 infection.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370743

Effect of rifampin, a potent inducer of drug-metabolizing enzymes, on the pharmacokinetics of raltegravir

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370743

Determination of drug permeability and prediction of drug absorption in Caco-2 monolayers

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370743

Comparison of inhibitory effects of the proton pump-inhibiting drugs omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole on human cytochrome P450 activities

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370743

HIV-1 integrase inhibitors that compete with the target DNA substrate define a unique strand transfer conformation for integrase

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370743

Efficient HIV-1 replication can occur in the absence of the viral matrix protein

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370743

Physiochemical and physiological mechanisms for the effects of food on drug absorption: the role of lipids and pH.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370743

Inter- and intra-patient variability of raltegravir pharmacokinetics in HIV-1-infected subjects.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370743

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370743

Effect of low-, moderate-, and high-fat meals on raltegravir pharmacokinetics

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370743

Effects of omeprazole on plasma levels of raltegravir

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370743

Implications of HIV-1 M group polymorphisms on integrase inhibitor efficacy and resistance: genetic and structural in silico analyses.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370743

Lack of a pharmacokinetic effect of raltegravir on midazolam: in vitro/in vivo correlation

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370743

Metabolism and disposition in humans of raltegravir (MK-0518), an anti-AIDS drug targeting the human immunodeficiency virus 1 integrase enzyme

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370743

Physicochemical determinants of passive membrane permeability: role of solute hydrogen-bonding potential and volume.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370743

Pharmacokinetics of the HIV integrase inhibitor S/GSK1349572 co-administered with acid-reducing agents and multivitamins in healthy volunteers

17 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22450971

12 December 2020

inferred from PubMed ID database lookup

Eradication of Helicobacter pylori is associated with increased exposure to delavirdine in hypochlorhydric HIV-positive patients

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22450971

12 December 2020

inferred from PubMed ID database lookup

Validation and application of Caco-2 assays for the in vitro evaluation of development candidate drugs as substrates or inhibitors of P-glycoprotein to support regulatory submissions

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22450971

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1128/AAC.06407-11

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18 October 2017

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18 October 2017

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