Conditional deletion of PTEN in peripheral T cells augments TCR-mediated activation but does not abrogate CD28 dependency or prevent anergy induction (Q42194172)

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English	Conditional deletion of PTEN in peripheral T cells augments TCR-mediated activation but does not abrogate CD28 dependency or prevent anergy induction	scientific article

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scholarly article

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Europe PubMed Central

18 October 2017

Conditional deletion of PTEN in peripheral T cells augments TCR-mediated activation but does not abrogate CD28 dependency or prevent anergy induction (English)

1 reference

Europe PubMed Central

18 October 2017

Thomas F. Gajewski

5

object named as

Thomas F Gajewski

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Europe PubMed Central

18 October 2017

author name string

Frederick L Locke

1

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Europe PubMed Central

18 October 2017

Yuan-yuan Zha

2

1 reference

Europe PubMed Central

18 October 2017

Yan Zheng

3

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Europe PubMed Central

18 October 2017

Gregory Driessens

4

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Europe PubMed Central

18 October 2017

language of work or name

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publication date

12 July 2013

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Europe PubMed Central

18 October 2017

Journal of Immunology

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Europe PubMed Central

18 October 2017

191

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Europe PubMed Central

18 October 2017

4

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Europe PubMed Central

18 October 2017

1677-1685

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Europe PubMed Central

18 October 2017

describes a project that uses

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3759681/fullTextXML

based on heuristic

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Egr2-dependent gene expression profiling and ChIP-Seq reveal novel biologic targets in T cell anergy

1 reference

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26 October 2017

Transcriptional regulator early growth response gene 2 (Egr2) is required for T cell anergy in vitro and in vivo

1 reference

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26 October 2017

Evidence implicating the Ras pathway in multiple CD28 costimulatory functions in CD4+ T cells

1 reference

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26 October 2017

Beta-catenin inhibits T cell activation by selective interference with linker for activation of T cells-phospholipase C-γ1 phosphorylation

1 reference

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Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

1 reference

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26 October 2017

Anergic T cells are metabolically anergic

1 reference

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26 October 2017

The role of the PI3K-AKT kinase pathway in T-cell development beyond the beta checkpoint

1 reference

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26 October 2017

Tenets of PTEN tumor suppression

1 reference

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26 October 2017

Use of Cre-adenovirus and CAR transgenic mice for efficient deletion of genes in post-thymic T cells

1 reference

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26 October 2017

Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia

1 reference

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26 October 2017

Tumor suppressor PTEN is a physiologic suppressor of chemoattractant-mediated neutrophil functions

1 reference

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An adenoviral vector for probing promoter activity in primary immune cells

1 reference

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26 October 2017

CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms

1 reference

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26 October 2017

Muscle-specific Pten deletion protects against insulin resistance and diabetes

1 reference

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26 October 2017

SHP-1 and SHP-2 associate with immunoreceptor tyrosine-based switch motif of programmed death 1 upon primary human T cell stimulation, but only receptor ligation prevents T cell activation

1 reference

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26 October 2017

Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]

1 reference

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26 October 2017

Actin cytoskeleton regulates calcium dynamics and NFAT nuclear duration

1 reference

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26 October 2017

The lipid phosphatase activity of PTEN is critical for stabilizing intercellular junctions and reverting invasiveness

1 reference

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26 October 2017

Gene Expression Omnibus: NCBI gene expression and hybridization array data repository

1 reference

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26 October 2017

IL-7 is critical for homeostatic proliferation and survival of naive T cells

1 reference

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26 October 2017

PTEN: life as a tumor suppressor

1 reference

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26 October 2017

Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-gamma but not TH2 cytokines

1 reference

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26 October 2017

Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection

1 reference

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26 October 2017

Transgenic expression of the coxsackie/adenovirus receptor enables adenoviral-mediated gene delivery in naive T cells

1 reference

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26 October 2017

B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes

1 reference

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26 October 2017

The tumor suppressor PTEN negatively regulates insulin signaling in 3T3-L1 adipocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759681

26 October 2017

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759681

26 October 2017

Molecular basis of T cell inactivation by CTLA-4

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759681

26 October 2017

Binding of phosphatidylinositol-3-OH kinase to CD28 is required for T-cell signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759681

26 October 2017

Anergic T-lymphocyte clones have altered inositol phosphate, calcium, and tyrosine kinase signaling pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759681

26 October 2017

Antiproliferative effect of IFN-gamma in immune regulation. III. Differential selection of TH1 and TH2 murine helper T lymphocyte clones using recombinant IL-2 and recombinant IFN-gamma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759681

26 October 2017

Antigen receptor-mediated anergy in resting T lymphocytes and T cell clones. Correlation with lymphokine secretion patterns

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759681

29 May 2018

T-cell lymphomas in T-cell-specific Pten-deficient mice originate in the thymus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759681

17 August 2018

Conditional deletion of Shp2 tyrosine phosphatase in thymocytes suppresses both pre-TCR and TCR signals.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759681

17 August 2018

The phosphatidylinositol phosphatase PTEN is under control of costimulation and regulates proliferation in human T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759681

17 August 2018

Cutting edge: distinct motifs within CD28 regulate T cell proliferation and induction of Bcl-XL.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759681

17 August 2018

A point mutation in CD28 distinguishes proliferative signals from survival signals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759681

17 August 2018

Monoclonal Antibodies Against T Cell Receptor/CD3 Complex Induce Cell Death of Th1 Clones in the Absence of Accessory Cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759681

17 August 2018

Cutting edge: spontaneous rejection of poorly immunogenic P1.HTR tumors by Stat6-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23851688

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based on heuristic

inferred from PubMed ID database lookup

T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance

1 reference

https://pubmed.ncbi.nlm.nih.gov/23851688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential Ras signaling via the antigen receptor and IL-2 receptor in primary T lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/23851688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Naive T cells are resistant to anergy induction by anti-CD3 antibodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/23851688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Costimulation with B7-1, IL-6, and IL-12 is sufficient for primary generation of murine antitumor cytolytic T lymphocytes in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/23851688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blocked Ras activation in anergic CD4+ T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23851688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cutting edge: T cell requirement for CD28 costimulation is due to negative regulation of TCR signals by PTEN

1 reference

https://pubmed.ncbi.nlm.nih.gov/23851688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.4049/JIMMUNOL.1202018

1 reference

Europe PubMed Central

18 October 2017

1 reference

Europe PubMed Central

18 October 2017

1 reference

Europe PubMed Central

18 October 2017

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