Ionization characteristics and chemical influences of aspartic acid residue 158 of papain and caricain determined by structure-related kinetic and computational techniques: multiple electrostatic modulators of active-centre chemistry (Q42227132)

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scientific article published on November 2000

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English	Ionization characteristics and chemical influences of aspartic acid residue 158 of papain and caricain determined by structure-related kinetic and computational techniques: multiple electrostatic modulators of active-centre chemistry	scientific article published on November 2000

Statements

scholarly article

1 reference

Europe PubMed Central

19 October 2017

Ionization characteristics and chemical influences of aspartic acid residue 158 of papain and caricain determined by structure-related kinetic and computational techniques: multiple electrostatic modulators of active-centre chemistry. (English)

1 reference

Europe PubMed Central

19 October 2017

author name string

Noble MA

1

1 reference

Europe PubMed Central

19 October 2017

Gul S

2

1 reference

Europe PubMed Central

19 October 2017

Verma CS

3

1 reference

Europe PubMed Central

19 October 2017

Brocklehurst K

4

1 reference

Europe PubMed Central

19 October 2017

language of work or name

0 references

publication date

1 November 2000

1 reference

Europe PubMed Central

19 October 2017

Biochemical Journal

1 reference

Europe PubMed Central

19 October 2017

351 Pt 3

1 reference

Europe PubMed Central

19 October 2017

723-733

1 reference

Europe PubMed Central

19 October 2017

A sound basis for pH-dependent kinetic studies on enzymes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221413

26 October 2017

Prediction of pH-dependent properties of proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221413

26 October 2017

Structure of chymopapain M the late-eluted chymopapain deduced by comparative modelling techniques and active-centre characteristics determined by pH-dependent kinetics of catalysis and reactions with time-dependent inhibitors: the Cys-25/His-159 io

1 reference

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26 October 2017

An unequivocal example of cysteine proteinase activity affected by multiple electrostatic interactions

1 reference

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26 October 2017

1 reference

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26 October 2017

Structure of papain refined at 1.65 A resolution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221413

26 October 2017

7-chloro-4-nitrobenzo-2-oxa-1,3-diazole: a new fluorigenic reagent for amino acids and other amines

1 reference

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26 October 2017

Calculation of the total electrostatic energy of a macromolecular system: solvation energies, binding energies, and conformational analysis

1 reference

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26 October 2017

Identification of signalling and non-signalling binding contributions to enzyme reactivity. Alternative combinations of binding interactions provide for change in transition-state geometry in reactions of papain

1 reference

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26 October 2017

Importance of hydrogen-bonding interactions involving the side chain of Asp158 in the catalytic mechanism of papain

1 reference

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26 October 2017

Structure-function relationships in the cysteine proteinases actinidin, papain and papaya proteinase omega. Three-dimensional structure of papaya proteinase omega deduced by knowledge-based modelling and active-centre characteristics determined by t

1 reference

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26 October 2017

A spectrophotometric method for the detection of contaminant chymopapains in preparations of papain. Selective modification of one type of thiol group in the chymopapains by a two-protonic-state reagent

1 reference

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26 October 2017

A necessary modification to the preparation of papain from any high-quality latex of Carica papaya and evidence for the structural integrity of the enzyme produced by traditional methods

1 reference

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Fluorescent and spin label probes of the environments of the sulfhydryl groups of porcine muscle adenylate kinase

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26 October 2017

The highly electrophilic character of 4-chloro-7-nitrobenzofurazan and possible consequences for its applications as a protein-labelling reagent

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26 October 2017

4-Chloro-7-nitrobenzo-2-oxa-1,3-diazole as a reactivity probe for the investigation of the thiol proteinases. evidence that ficin and bromelain may lack carboxyl groups conformationally equivalent to that of aspartic acid-158 of papain

1 reference

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Preparation of fully active ficin from Ficus glabrata by covalent chromatography and characterization of its active centre by using 2,2'-depyridyl disulphide as a reactivity probe

1 reference

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26 October 2017

Ionization characteristics of the Cys-25/His-159 interactive system and of the modulatory group of papain: resolution of ambiguity by electronic perturbation of the quasi-2-mercaptopyridine leaving group in a new pyrimidyl disulphide reactivity prob

1 reference

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29 May 2018

The structural origins of the unusual specificities observed in the isolation of chymopapain M and actinidin by covalent chromatography and the lack of inhibition of chymopapain M by cystatin

1 reference

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Regression analysis, experimental error, and statistical criteria in the design and analysis of experiments for discrimination between rival kinetic models.

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29 May 2018

Covalent chromatography. Preparation of fully active papain from dried papaya latex

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29 May 2018

On the calculation of electrostatic interactions in proteins.

1 reference

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29 May 2018

Structural and electrostatic differences between actinidin and papain account for differences in activity

1 reference

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29 May 2018

A general kinetic equation for multihydronic state reactions and rapid procedures for parameter evaluation.

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Characterization of the electrostatic perturbation of a catalytic site (Cys)-S-/(His)-Im+H ion-pair in one type of serine proteinase architecture by kinetic and computational studies on chemically mutated subtilisin variants.

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Long-range surface charge-charge interactions in proteins. Comparison of experimental results with calculations from a theoretical method.

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Secondary structure and membrane localization of synthetic segments and a truncated form of the IsK (minK) protein.

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Investigation of the active site of papain with fluorescent probes

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Ficin: a cysteine proteinase with binding site-catalytic site signalling characteristics intermediate between those of papain and actinidin

1 reference

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The reactivity of SH groups with a fluorogenic reagent

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https://pubmed.ncbi.nlm.nih.gov/11042128

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Contribution of long-range electrostatic interactions to the stabilization of the catalytic transition state of the serine protease subtilisin BPN'

1 reference

https://pubmed.ncbi.nlm.nih.gov/11042128

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Effects of site-specific mutations on the kinetically influential ionizations of papain

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A classical enzyme active center motif lacks catalytic competence until modulated electrostatically

1 reference

https://pubmed.ncbi.nlm.nih.gov/11042128

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Rapid kinetic studies and structural determination of a cysteine proteinase mutant imply that residue 158 in caricain has a major effect upon the ability of the active site histidine to protonate a dipyridyl probe

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Potential antileukemic and immunosuppressive drugs. Preparation and in vitro pharmacological activity of some 2,1,3-benzoxadiazoles (benzofurazans) and their N-oxides (benzofuroxans)

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Probing the active site of the reconstituted aspartate/glutamate carrier from mitochondria. Structure/function relationship involving one lysine and two cysteine residues

1 reference

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1 Electrostatic effects in protein folding, stability, and function

1 reference

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The preparation and properties of two new chromogenic substrates of trypsin

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Identifiers

10.1042/0264-6021:3510723

1 reference

Europe PubMed Central

19 October 2017

1 reference

Europe PubMed Central

19 October 2017

1 reference

Europe PubMed Central

19 October 2017

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