Metformin directly binds the alarmin HMGB1 and inhibits its proinflammatory activity. (Q42256796)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28373282%20AND%20SRC:MED&resulttype=core&format=json

15 March 2020

title

Metformin directly binds the alarmin HMGB1 and inhibits its proinflammatory activity (English)

1 reference

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15 March 2020

1 reference

2

1 reference

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15 March 2020

author name string

Takahiro Horiuchi

1

1 reference

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15 March 2020

Yoshihiro Narumi

3

1 reference

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15 March 2020

Tomohiro Kimura

4

1 reference

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15 March 2020

Takashi Hayashi

5

1 reference

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15 March 2020

Keisuke Nagano

6

1 reference

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15 March 2020

Keyue Liu

7

1 reference

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15 March 2020

Masahiro Nishibori

8

1 reference

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15 March 2020

Sohei Tsukita

9

1 reference

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15 March 2020

Tetsuya Yamada

10

1 reference

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15 March 2020

Hideki Katagiri

11

1 reference

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15 March 2020

Ryutaro Shirakawa

12

1 reference

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15 March 2020

Hisanori Horiuchi

13

1 reference

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15 March 2020

language of work or name

English

0 references

publication date

3 April 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28373282%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

15 March 2020

published in

1 reference

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15 March 2020

volume

292

1 reference

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15 March 2020

issue

20

1 reference

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15 March 2020

page(s)

8436-8446

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28373282%20AND%20SRC:MED&resulttype=core&format=json

Pleiotropic benefits of metformin: macrophage targeting its anti-inflammatory mechanisms

15 March 2020

cites work

1 reference

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Metformin and Inflammation: Its Potential Beyond Glucose-lowering Effect

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26 October 2017

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HMGB1 neutralization is associated with bacterial translocation during acetaminophen hepatotoxicity

26 October 2017

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26 October 2017

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Metformin Down-regulates TNF-α Secretion via Suppression of Scavenger Receptors in Macrophages

26 October 2017

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26 October 2017

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Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

26 October 2017

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Metformin ameliorates methotrexate-induced hepatotoxicity

26 October 2017

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Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release

26 October 2017

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Redox modification of cysteine residues regulates the cytokine activity of high mobility group box-1 (HMGB1)

26 October 2017

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Macrophage-mediated inflammation in metabolic disease

26 October 2017

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HMGB1 is a therapeutic target for sterile inflammation and infection

26 October 2017

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Metformin inhibits HMGB1 release in LPS‐treated RAW 264.7 cells and increases survival rate of endotoxaemic mice

26 October 2017

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High-mobility group box 1, oxidative stress, and disease

26 October 2017

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Tail-Mediated Collapse of HMGB1 Is Dynamic and Occurs via Differential Binding of the Acidic Tail to the A and B Domains

26 October 2017

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HMGB1, a potent proinflammatory cytokine in sepsis

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26 October 2017

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26 October 2017

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26 October 2017

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26 October 2017

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26 October 2017

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26 October 2017

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26 October 2017

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26 October 2017

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The DNA binding site of HMG1 protein is composed of two similar segments (HMG boxes), both of which have counterparts in other eukaryotic regulatory proteins

26 October 2017

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Metformin ameliorates acetaminophen hepatotoxicity via Gadd45β-dependent regulation of JNK signaling in mice.

26 October 2017

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17 August 2018

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Metformin decreases high-fat diet-induced renal injury by regulating the expression of adipokines and the renal AMP-activated protein kinase/acetyl-CoA carboxylase pathway in mice.

17 August 2018

1 reference

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Anti-high mobility group box-1 antibody therapy for traumatic brain injury

17 August 2018

1 reference

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High-mobility group box protein 1 neutralization reduces development of diet-induced atherosclerosis in apolipoprotein e-deficient mice.

17 August 2018

1 reference

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Metformin inhibits TNF-alpha-induced IkappaB kinase phosphorylation, IkappaB-alpha degradation and IL-6 production in endothelial cells through PI3K-dependent AMPK phosphorylation

17 August 2018

1 reference

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Anti-high mobility group box 1 monoclonal antibody ameliorates brain infarction induced by transient ischemia in rats

17 August 2018

1 reference

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Elevated high-mobility group box 1 levels in patients with cerebral and myocardial ischemia

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5437248

Metformin protects against carbon tetrachloride hepatotoxicity in mice

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5437248

Metformin in non-alcoholic steatohepatitis.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5437248

HMGB1 interacts differentially with members of the Rel family of transcription factors

17 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M116.769380

Domain-domain interactions in high mobility group 1 protein (HMG1)

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28373282

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M116.769380

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28373282%20AND%20SRC:MED&resulttype=core&format=json

15 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28373282%20AND%20SRC:MED&resulttype=core&format=json

15 March 2020

PubMed publication ID

28373282

1 reference