IRAK4 turns IL-10+ phospho-FOXO+ monocytes into pro-inflammatory cells by suppression of protein kinase B. (Q42269867)

19 October 2017

IRAK4 turns IL-10+ phospho-FOXO+ monocytes into pro-inflammatory cells by suppression of protein kinase B. (English)

1 reference

19 October 2017

Benjamin Over

1

1 reference

19 October 2017

Saskia Ziegler

2

1 reference

19 October 2017

Sandra Foermer

3

1 reference

19 October 2017

Alexander N R Weber

4

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19 October 2017

Konrad A Bode

5

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19 October 2017

Klaus Heeg

6

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19 October 2017

Isabelle Bekeredjian-Ding

7

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19 October 2017

language of work or name

English

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publication date

30 April 2013

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European Journal of Immunology

19 October 2017

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19 October 2017

43

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19 October 2017

6

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19 October 2017

1630-1642

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Monocyte-mediated defense against microbial pathogens.

19 October 2017

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201243217

Normal responses to injury prevent systemic inflammation and can be immunosuppressive

21 January 2018

1 reference

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The proinflammatory CD14+CD16+DR++ monocytes are a major source of TNF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201243217

Toll-like receptor signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201243217

Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201243217

Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201243217

What the Myddosome structure tells us about the initiation of innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201243217

Functional diversity and regulation of different interleukin-1 receptor-associated kinase (IRAK) family members

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201243217

Summary and comparison of the signaling mechanisms of the Toll/interleukin-1 receptor family

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201243217

Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201243217

NF-kappaB: linking inflammation and immunity to cancer development and progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201243217

Clinical features and outcome of patients with IRAK-4 and MyD88 deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201243217

Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201243217

Pyogenic bacterial infections in humans with MyD88 deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201243217

Crystal structures of IRAK-4 kinase in complex with inhibitors: a serine/threonine kinase with tyrosine as a gatekeeper

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201243217

Regulation of IRAK-4 kinase activity via autophosphorylation within its activation loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201243217

Pyogenic bacterial infections in humans with IRAK-4 deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201243217

Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201243217

A role for IFN-alpha beta in virus infection-induced sensitization to endotoxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201243217

NODs: intracellular proteins involved in inflammation and apoptosis

21 January 2018

1 reference

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A critical role for hemolysins and bacterial lipoproteins in Staphylococcus aureus-induced activation of the Nlrp3 inflammasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201243217

Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201243217

Mechanisms of TNF induction by heat-killed Staphylococcus aureus differ upon the origin of mononuclear phagocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201243217

Nucleotide-binding oligomerization domain proteins are innate immune receptors for internalized Streptococcus pneumoniae

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201243217

The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201243217

IFN-gamma suppresses IL-10 production and synergizes with TLR2 by regulating GSK3 and CREB/AP-1 proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201243217

Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide-induced interleukin-12 production in dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201243217

Role of the phosphatidylinositol 3 kinase-Akt pathway in the regulation of IL-10 and IL-12 by Porphyromonas gingivalis lipopolysaccharide

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201243217

Lipopolysaccharide-induced production of interleukin-10 is promoted by the serine/threonine kinase Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201243217

Role of the mTOR pathway in LPS-activated monocytes: influence of hypertonic saline

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201243217

mTOR and GSK-3 shape the CD4+ T-cell stimulatory and differentiation capacity of myeloid DCs after exposure to LPS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201243217

T cell-independent, TLR-induced IL-12p70 production in primary human monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201243217

Clinical presentation and management of mTOR inhibitor-associated stomatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201243217

Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201243217

Phosphatidylinositol 3-kinase is involved in Toll-like receptor 4-mediated cytokine expression in mouse macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201243217

TLR4/MyD88/PI3K interactions regulate TLR4 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201243217

The regulation of IL-10 production by immune cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201243217

Many forks in the path: cycling with FoxO.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201243217

FOXO3 programs tumor-associated DCs to become tolerogenic in human and murine prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201243217

Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201243217

Definition of human blood monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201243217

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1002/EJI.201243217

1 reference

19 October 2017

1 reference