Alternative implication of CXCR4 in JAK2/STAT3 activation in small cell lung cancer (Q42277237)

19 October 2017

Alternative implication of CXCR4 in JAK2/STAT3 activation in small cell lung cancer (English)

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19 October 2017

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19 October 2017

M Pfeiffer

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19 October 2017

M Leick

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19 October 2017

J Catusse

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19 October 2017

A Schmitt-Graeff

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19 October 2017

M Burger

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19 October 2017

language of work or name

English

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publication date

19 May 2009

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British Journal of Cancer

19 October 2017

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19 October 2017

100

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19 October 2017

12

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19 October 2017

1949-1956

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https://scigraph.springernature.com/pub.10.1038/sj.bjc.6605068

19 October 2017

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cites work

Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas

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Targeting the cytoplasmic and nuclear functions of signal transducers and activators of transcription 3 for cancer therapy

26 October 2017

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CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-associated vasculature

26 October 2017

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Manipulating the chemokine-chemokine receptor network to treat cancer

26 October 2017

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Small molecule inhibitors of Stat3 signaling pathway.

26 October 2017

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Structure, function, and regulation of STAT proteins

26 October 2017

1 reference

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The pivotal role of CXCL12 (SDF-1)/CXCR4 axis in bone metastasis

26 October 2017

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JAK-2 mutations and their relevance to myeloproliferative disease

26 October 2017

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26 October 2017

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The pleiotropic effects of the SDF-1-CXCR4 axis in organogenesis, regeneration and tumorigenesis.

26 October 2017

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Tracking STAT nuclear traffic

26 October 2017

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Vav1 and Rac control chemokine-promoted T lymphocyte adhesion mediated by the integrin alpha4beta1

26 October 2017

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CXCR4 chemokine receptor and integrin signaling co-operate in mediating adhesion and chemoresistance in small cell lung cancer (SCLC) cells.

26 October 2017

1 reference

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Stable expression of constitutively-activated STAT3 in benign prostatic epithelial cells changes their phenotype to that resembling malignant cells

26 October 2017

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Identification of the cytoplasmic domains of CXCR4 involved in Jak2 and STAT3 phosphorylation.

26 October 2017

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CXCL12 signaling is independent of Jak2 and Jak3.

26 October 2017

1 reference

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Activation of Stat3 by receptor tyrosine kinases and cytokines regulates survival in human non-small cell carcinoma cells

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2714241

Chemokines integrate JAK/STAT and G‐protein pathways during chemotaxis and calcium flux responses

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2714241

Regulation of cellular proliferation, cytoskeletal function, and signal transduction through CXCR4 and c-Kit in small cell lung cancer cells

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2714241

Stats: transcriptional control and biological impact

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2714241

Functional inactivation of CXC chemokine receptor 4-mediated responses through SOCS3 up-regulation

26 October 2017

1 reference

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Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2714241

Janus kinase 2 is involved in stromal cell-derived factor-1alpha-induced tyrosine phosphorylation of focal adhesion proteins and migration of hematopoietic progenitor cells

26 October 2017

1 reference

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Involvement of chemokine receptors in breast cancer metastasis

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2714241

The chemokine SDF-1alpha triggers CXCR4 receptor dimerization and activates the JAK/STAT pathway

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2714241

26 October 2017

1 reference

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Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: a mechanism for small cell lung cancer growth and drug resistance in vivo

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2714241

Nerve growth factor abrogates the tumorigenicity of human small cell lung cancer cell lines

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2714241

STATs and gene regulation

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2714241

Biological heterogeneity of small cell lung cancer

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2714241

A crosstalk between intracellular CXCR7 and CXCR4 involved in rapid CXCL12-triggered integrin activation but not in chemokine-triggered motility of human T lymphocytes and CD34+ cells

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2714241

Jak kinase activity is required for lymphoma invasion and metastasis

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2714241

Identification of a CXCR4 antagonist, a T140 analog, as an anti-rheumatoid arthritis agent

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2714241

The STAT3 isoforms alpha and beta have unique and specific functions

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2714241

Functional expression of CXCR4 (CD184) on small-cell lung cancer cells mediates migration, integrin activation, and adhesion to stromal cells.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2714241

Chemokine stromal cell-derived factor-1alpha modulates VLA-4 integrin-mediated multiple myeloma cell adhesion to CS-1/fibronectin and VCAM-1.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2714241

CXCR-4, a chemokine receptor, is overexpressed in and required for proliferation of glioblastoma tumor cells.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2714241

The chemokine SDF-1 activates the integrins LFA-1, VLA-4, and VLA-5 on immature human CD34(+) cells: role in transendothelial/stromal migration and engraftment of NOD/SCID mice

17 August 2018

1 reference

PubMed

12 December 2020

1 reference

12 December 2020

Granulocyte colony-stimulating factor activation of Stat3 alpha and Stat3 beta in immature normal and leukemic human myeloid cells

1 reference

PubMed

12 December 2020

Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4

1 reference

PubMed

12 December 2020

Identifiers

DOI

10.1038/SJ.BJC.6605068

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Dimensions Publication ID

19 October 2017

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19 October 2017

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