Use of mechanistic modeling to assess interindividual variability and interspecies differences in active uptake in human and rat hepatocytes (Q42282480)

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scientific article published on 4 June 2012

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English	Use of mechanistic modeling to assess interindividual variability and interspecies differences in active uptake in human and rat hepatocytes	scientific article published on 4 June 2012

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scholarly article

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3 February 2020

Use of mechanistic modeling to assess interindividual variability and interspecies differences in active uptake in human and rat hepatocytes (English)

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3 February 2020

Aleksandra Galetin

4

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3 February 2020

author name string

Karelle Ménochet

1

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3 February 2020

Kathryn E Kenworthy

2

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3 February 2020

J Brian Houston

3

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publication date

4 June 2012

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3 February 2020

Drug Metabolism and Disposition

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3 February 2020

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3 February 2020

1744-1756

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3 February 2020

Mechanistic pharmacokinetic modeling for the prediction of transporter-mediated disposition in humans from sandwich culture human hepatocyte data

1 reference

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26 October 2017

Simultaneous assessment of uptake and metabolism in rat hepatocytes: a comprehensive mechanistic model

1 reference

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26 October 2017

Determination of OATP-, NTCP- and OCT-mediated substrate uptake activities in individual and pooled batches of cryopreserved human hepatocytes.

1 reference

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Physiologically based pharmacokinetic modeling to predict transporter-mediated clearance and distribution of pravastatin in humans

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Localization of P-gp (Abcb1) and Mrp2 (Abcc2) in freshly isolated rat hepatocytes

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Predominant contribution of OATP1B3 to the hepatic uptake of telmisartan, an angiotensin II receptor antagonist, in humans

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Cyclosporine markedly raises the plasma concentrations of repaglinide

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17 August 2018

Polymorphic organic anion transporting polypeptide 1B1 is a major determinant of repaglinide pharmacokinetics

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1 reference

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30 September 2018

In vivo inhibition of oxidative drug metabolism by, and acute toxicity of, 1-aminobenzotriazole (ABT). A tool for biochemical toxicology

1 reference

https://pubmed.ncbi.nlm.nih.gov/22665271

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Use of hepatocytes to assess the contribution of hepatic uptake to clearance in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/22665271

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of human metabolic clearance from in vitro systems: retrospective analysis and prospective view

1 reference

https://pubmed.ncbi.nlm.nih.gov/22665271

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of cryopreservation on the activity of OATP1B1/3 and OCT1 in isolated human hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22665271

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The impact of pharmacogenetics of metabolic enzymes and transporters on the pharmacokinetics of telmisartan in healthy volunteers

1 reference

https://pubmed.ncbi.nlm.nih.gov/22665271

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Culture period-dependent changes in the uptake of transporter substrates in sandwich-cultured rat and human hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22665271

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The impact of hepatic uptake on the pharmacokinetics of organic anions

1 reference

https://pubmed.ncbi.nlm.nih.gov/22665271

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

OATP1B1/1B3 activity in plated primary human hepatocytes over time in culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/22665271

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Absorption, metabolism, and excretion of intravenously and orally administered [14C]telmisartan in healthy volunteers

1 reference

https://pubmed.ncbi.nlm.nih.gov/22665271

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1124/DMD.112.046193

1 reference

Europe PubMed Central

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3 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22665271%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

1 reference

Europe PubMed Central

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3 February 2020

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