A protein homeostasis signature in healthy brains recapitulates tissue vulnerability to Alzheimer's disease. (Q42365992)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27532054%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

title

A protein homeostasis signature in healthy brains recapitulates tissue vulnerability to Alzheimer's disease (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27532054%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

0 references

1

1 reference

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21 March 2020

Pietro Sormanni

2

1 reference

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21 March 2020

Prajwal Ciryam

4

1 reference

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21 March 2020

Michele Vendruscolo

6

1 reference

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21 March 2020

author name string

Giulia Vecchi

3

1 reference

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21 March 2020

Christopher M Dobson

5

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21 March 2020

publication date

10 August 2016

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21 March 2020

1 reference

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21 March 2020

volume

2

1 reference

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21 March 2020

issue

8

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21 March 2020

page(s)

e1600947

1 reference

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A transcriptional signature of Alzheimer's disease is associated with a metastable subproteome at risk for aggregation

21 March 2020

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29 May 2018

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1 December 2018

https://pubmed.ncbi.nlm.nih.gov/27532054

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A chaperome subnetwork safeguards proteostasis in aging and neurodegenerative disease

1 reference

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UniProt: a hub for protein information

29 May 2018

1 reference

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The amyloid state and its association with protein misfolding diseases.

29 May 2018

1 reference

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Widespread aggregation and neurodegenerative diseases are associated with supersaturated proteins

29 May 2018

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Genes and pathways underlying regional and cell type changes in Alzheimer's disease

29 May 2018

1 reference

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101 labeled brain images and a consistent human cortical labeling protocol

29 May 2018

1 reference

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Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau

29 May 2018

1 reference

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An anatomically comprehensive atlas of the adult human brain transcriptome

29 May 2018

1 reference

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Insights into the regulation of protein abundance from proteomic and transcriptomic analyses

29 May 2018

1 reference

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Neuropathological alterations in Alzheimer disease

29 May 2018

1 reference

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Molecular chaperones in protein folding and proteostasis

29 May 2018

1 reference

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Neuronal activity regulates the regional vulnerability to amyloid-β deposition

29 May 2018

1 reference

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Alzheimer's disease: the challenge of the second century

29 May 2018

1 reference

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Amyloid-like aggregates sequester numerous metastable proteins with essential cellular functions

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4980108

Deletion of CD14 attenuates Alzheimer's disease pathology by influencing the brain's inflammatory milieu

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4980108

Automatic parcellation of human cortical gyri and sulci using standard anatomical nomenclature

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4980108

Prion-like transmission of protein aggregates in neurodegenerative diseases

29 May 2018

1 reference

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29 May 2018

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KEGG for representation and analysis of molecular networks involving diseases and drugs

29 May 2018

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Amyloid deposition is associated with impaired default network function in older persons without dementia

29 May 2018

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MRI correlates of neurofibrillary tangle pathology at autopsy: a voxel-based morphometry study

29 May 2018

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Proteomic identification of novel proteins associated with Lewy bodies

29 May 2018

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Adapting proteostasis for disease intervention

29 May 2018

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Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

29 May 2018

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Ageing and neuronal vulnerability

29 May 2018

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A specific amyloid-beta protein assembly in the brain impairs memory

29 May 2018

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An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest

29 May 2018

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Progressive disruption of cellular protein folding in models of polyglutamine diseases.

29 May 2018

1 reference

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Statistical significance for genomewide studies

29 May 2018

1 reference

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Alzheimer's disease is a synaptic failure

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4980108

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4980108

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4980108

Alpha-synuclein in Lewy bodies

29 May 2018

1 reference

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Ageing and Parkinson's disease: substantia nigra regional selectivity

29 May 2018

1 reference

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Neuropathological stageing of Alzheimer-related changes

29 May 2018

1 reference

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Regional profiles of the candidate tau PET ligand 18F-AV-1451 recapitulate key features of Braak histopathological stages

29 May 2018

1 reference

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Chronic optogenetic activation augments aβ pathology in a mouse model of Alzheimer disease

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4980108

Spreading of neurodegenerative pathology via neuron-to-neuron transmission of β-amyloid.

17 August 2018

1 reference

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β-Amyloid precursor protein and tau protein levels are differently regulated in human cerebellum compared to brain regions vulnerable to Alzheimer's type neurodegeneration.

17 August 2018

1 reference

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False discovery rate, sensitivity and sample size for microarray studies.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4980108

17 August 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/27532054

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1126/SCIADV.1600947

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27532054%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27532054%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

PubMed publication ID

27532054

1 reference