Spike bursts increase amyloid-β 40/42 ratio by inducing a presenilin-1 conformational change (Q42436815)

31 October 2017

Spike bursts increase amyloid-β 40/42 ratio by inducing a presenilin-1 conformational change (English)

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31 October 2017

6

Nils Brose

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31 October 2017

Iftach Dolev

1

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31 October 2017

Hilla Fogel

2

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31 October 2017

Hila Milshtein

3

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31 October 2017

Yevgeny Berdichevsky

4

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31 October 2017

Noa Lipstein

5

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31 October 2017

Neta Gazit

7

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31 October 2017

Inna Slutsky

8

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31 October 2017

language of work or name

English

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publication date

7 April 2013

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31 October 2017

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31 October 2017

16

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31 October 2017

5

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31 October 2017

587-595

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https://scigraph.springernature.com/pub.10.1038/nn.3376

31 October 2017

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Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids

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Production of the Alzheimer amyloid beta protein by normal proteolytic processing

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Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.

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The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease

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Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio

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Loss-of-function presenilin mutations in Alzheimer disease. Talking Point on the role of presenilin mutations in Alzheimer disease

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When loss is gain: reduced presenilin proteolytic function leads to increased Abeta42/Abeta40. Talking Point on the role of presenilin mutations in Alzheimer disease

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The genetics of Alzheimer disease: back to the future

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An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

21 January 2018

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Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

21 January 2018

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Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

21 January 2018

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Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms

21 January 2018

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Novel research horizons for presenilins and γ-secretases in cell biology and disease

21 January 2018

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Molecular genetics of Alzheimer's disease: an update

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APP processing and synaptic function

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Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo.

21 January 2018

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Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo

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Bursts as a unit of neural information: making unreliable synapses reliable

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Amyloid-beta as a positive endogenous regulator of release probability at hippocampal synapses.

21 January 2018

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Amyloid beta from axons and dendrites reduces local spine number and plasticity.

21 January 2018

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Allosteric modulation of PS1/gamma-secretase conformation correlates with amyloid beta(42/40) ratio

21 January 2018

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Familial Alzheimer's disease presenilin 1 mutations cause alterations in the conformation of presenilin and interactions with amyloid precursor protein.

21 January 2018

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Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

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Total arrest of spontaneous and evoked synaptic transmission but normal synaptogenesis in the absence of Munc13-mediated vesicle priming

21 January 2018

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Cell biology of the presynaptic terminal

21 January 2018

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Inhibition of dynamin completely blocks compensatory synaptic vesicle endocytosis

21 January 2018

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Short-term synaptic plasticity

21 January 2018

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Paired-pulse facilitation and depression at unitary synapses in rat hippocampus: quantal fluctuation affects subsequent release.

21 January 2018

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Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase

21 January 2018

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Cortico-hippocampal communication by way of parallel parahippocampal-subicular pathways

21 January 2018

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Visual experience and deprivation bidirectionally modify the composition and function of NMDA receptors in visual cortex

21 January 2018

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High frequency action potential bursts (>or= 100 Hz) in L2/3 and L5B thick tufted neurons in anaesthetized and awake rat primary somatosensory cortex.

21 January 2018

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Temporal interaction between single spikes and complex spike bursts in hippocampal pyramidal cells

21 January 2018

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Distinct neuronal coding schemes in memory revealed by selective erasure of fast synchronous synaptic transmission

21 January 2018

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Presenilins and γ-secretase: structure, function, and role in Alzheimer Disease

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Nonsteroidal anti-inflammatory drugs lower Abeta42 and change presenilin 1 conformation

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Impact of aging on hippocampal function: plasticity, network dynamics, and cognition

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Education and the prevalence of dementia and Alzheimer's disease

21 January 2018

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Influence of education and occupation on the incidence of Alzheimer's disease

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Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice

21 January 2018

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Preventive and therapeutic types of environmental enrichment counteract beta amyloid pathology by different molecular mechanisms.

21 January 2018

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beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

21 January 2018

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Basal GABA regulates GABA(B)R conformation and release probability at single hippocampal synapses.

21 January 2018

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Compartmentalization of the GABAB receptor signaling complex is required for presynaptic inhibition at hippocampal synapses.

21 January 2018

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Cortico-hippocampal communication by way of parallel parahippocampal-subicular pathways

21 January 2018

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12 December 2020

RECEPTIVE FIELDS OF CELLS IN STRIATE CORTEX OF VERY YOUNG, VISUALLY INEXPERIENCED KITTENS

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12 December 2020

Alzheimer amyloid protein precursor in the rat hippocampus: transport and processing through the perforant path

1 reference

12 December 2020

Proteolytic processing and cell biological functions of the amyloid precursor protein

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12 December 2020

Identifiers

DOI

10.1038/NN.3376

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Dimensions Publication ID

31 October 2017

1048972312

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Fatcat ID

release_bvvlgeywuvbmhffr4i2yyvoohm

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Fatcat

https://api.fatcat.wiki/v0/release/bvvlgeywuvbmhffr4i2yyvoohm

24 November 2022

mapped directly with Wikidata item

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