Medulloblastoma Sensitivity to 17-Allylamino-17-demethoxygeldanamycin Requires MEK/ERK (Q42440167)

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31 October 2017

Medulloblastoma Sensitivity to 17-Allylamino-17-demethoxygeldanamycin Requires MEK/ERK (English)

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https://api.crossref.org/works/10.1074/JBC.M211600200

26 December 2023

Medulloblastoma sensitivity to 17-allylamino-17-demethoxygeldanamycin requires MEK/ERKM (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12709419

26 December 2023

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26 December 2023

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https://api.crossref.org/works/10.1074/JBC.M211600200

26 December 2023

author

Christopher Calabrese

1

object named as

Christopher Calabrese

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31 October 2017

4

Richard Gilbertson

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12709419

26 December 2023

author name string

Adrian Frank

2

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31 October 2017

Kirsteen Maclean

3

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31 October 2017

language of work or name

English

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publication date

22 April 2003

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full work available at URL

31 October 2017

9

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based on heuristic

inferred from page(s)

http://www.jbc.org/content/278/27/24951.full.pdf

file format

Portable Document Format

online access status

open access

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https://api.elsevier.com/content/article/PII:S0021925820869579?httpAccept=text/xml

26 December 2023

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https://api.crossref.org/works/10.1074/JBC.M211600200

https://api.elsevier.com/content/article/PII:S0021925820869579?httpAccept=text/plain

26 December 2023

1 reference

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https://syndication.highwire.org/content/doi/10.1074/jbc.M211600200

26 December 2023

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Journal of Biological Chemistry

26 December 2023

published in

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31 October 2017

278

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31 October 2017

27

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31 October 2017

24951-24959

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Increased tyrosine kinase activity associated with the protein encoded by the activated neu oncogene

31 October 2017

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neu/ERBB2 cooperates with p53-172H during mammary tumorigenesis in transgenic mice

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Depletion of p185erbB2, Raf-1 and mutant p53 proteins by geldanamycin derivatives correlates with antiproliferative activity

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The hsp90-binding antibiotic geldanamycin decreases Raf levels and epidermal growth factor signaling without disrupting formation of signaling complexes or reducing the specific enzymatic activity of Raf kinase

21 January 2018

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Geldanamycin-stimulated destabilization of mutated p53 is mediated by the proteasome in vivo

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Ansamycin antibiotics inhibit Akt activation and cyclin D expression in breast cancer cells that overexpress HER2.

21 January 2018

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DT-Diaphorase expression and tumor cell sensitivity to 17-allylamino, 17-demethoxygeldanamycin, an inhibitor of heat shock protein 90

21 January 2018

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Childhood medulloblastoma: progress and future challenges

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Metastasis stage, adjuvant treatment, and residual tumor are prognostic factors for medulloblastoma in children: conclusions from the Children's Cancer Group 921 randomized phase III study.

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Mitotic percentage index: a new prognostic factor for childhood medulloblastoma.

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Prognostic significance of the c-erbB-2 oncogene product in childhood medulloblastoma

21 January 2018

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Clinical and molecular stratification of disease risk in medulloblastoma

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Treatment of vascular smooth muscle cells with antisense phosphorothioate oligodeoxynucleotides directed against p42 and p44 mitogen-activated protein kinases abolishes DNA synthesis in response to platelet-derived growth factor.

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The ErbB signaling network: receptor heterodimerization in development and cancer

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HER-2/neu blocks tumor necrosis factor-induced apoptosis via the Akt/NF-kappaB pathway

21 January 2018

1 reference

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Requirement for a hsp90 chaperone-dependent MEK1/2-ERK pathway for B cell antigen receptor-induced cyclin D2 expression in mature B lymphocytes

21 January 2018

1 reference

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Destabilization of Raf-1 by geldanamycin leads to disruption of the Raf-1-MEK-mitogen-activated protein kinase signalling pathway

21 January 2018

1 reference

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Geldanamycin-induced destabilization of Raf-1 involves the proteasome

21 January 2018

1 reference

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The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin

21 January 2018

1 reference

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Opposite effects of the Hsp90 inhibitor Geldanamycin: induction of apoptosis in PC12, and differentiation in N2A cells

21 January 2018

1 reference

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Taxol-induced apoptosis depends on MAP kinase pathways (ERK and p38) and is independent of p53.

21 January 2018

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Requirement for ERK activation in cisplatin-induced apoptosis

21 January 2018

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Role of mitogen-activated protein kinases in the response of tumor cells to chemotherapy

21 January 2018

1 reference

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The Raf/MEK/ERK pathway: new concepts of activation.

21 January 2018

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The ups and downs of MEK kinase interactions

21 January 2018

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Mos activates MAP kinase in mouse oocytes through two opposite pathways.

21 January 2018

1 reference

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Mos induces the in vitro activation of mitogen-activated protein kinases in lysates of frog oocytes and mammalian somatic cells

21 January 2018

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c-mos proto-oncogene RNA transcripts in mouse tissues: structural features, developmental regulation, and localization in specific cell types

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Expression of mos in astrocytic tumors and its potential role in neoplastic progression.

21 January 2018

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The Raf/MEK/ERK signal transduction cascade as a target for chemotherapeutic intervention in leukemia

21 January 2018

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Caspase activation in etoposide-treated fibroblasts is correlated to ERK phosphorylation and both events are blocked by polyamine depletion

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Signal transduction--directed cancer treatments

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Transformation of NIH 3T3 cells by overexpression of the normal coding sequence of the rat neu gene.

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Amplification of the neu/erbB-2 oncogene in a mouse model of mammary tumorigenesis.

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MEK wars, a new front in the battle against cancer

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Anticancer therapy targeting the erbB family of receptor tyrosine kinases

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Identifiers

1 reference

31 October 2017

1 reference