The Role of a Conserved Region of the Second Intracellular Loop in AT1 Angiotensin Receptor Activation and Signaling (Q42441168)

31 October 2017

The role of a conserved region of the second intracellular loop in AT1 angiotensin receptor activation and signaling (English)

1 reference

https://api.crossref.org/works/10.1210/EN.2002-0135

31 October 2017

The Role of a Conserved Region of the Second Intracellular Loop in AT1 Angiotensin Receptor Activation and Signaling (English)

1 reference

2 January 2024

1 reference

https://api.crossref.org/works/10.1210/EN.2002-0135

2 January 2024

author name string

Zsuzsanna Gáborik

1

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31 October 2017

Gowraganahalli Jagadeesh

2

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31 October 2017

Meng Zhang

3

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31 October 2017

András Spät

4

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31 October 2017

László Hunyady

6

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31 October 2017

Kevin J. Catt

5

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12746278

reference URL

2 January 2024

language of work or name

English

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publication date

1 June 2003

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31 October 2017

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31 October 2017

144

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31 October 2017

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31 October 2017

2220-2228

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The ligand binding site of the angiotensin AT1 receptor.

31 October 2017

https://api.crossref.org/works/10.1210/EN.2002-0135

1

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Generation and role of calcium signal in adrenal glomerulosa cells

2 January 2024

https://api.crossref.org/works/10.1210/EN.2002-0135

3

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Signal transduction of angiotensin II type 1 receptor through receptor tyrosine kinase

2 January 2024

https://api.crossref.org/works/10.1210/EN.2002-0135

4

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Angiotensin II-mediated signal transduction pathways.

2 January 2024

https://api.crossref.org/works/10.1210/EN.2002-0135

5

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Agonist-induced phosphorylation of the angiotensin AT1a receptor is localized to a serine/threonine-rich region of its cytoplasmic tail

2 January 2024

https://api.crossref.org/works/10.1210/EN.2002-0135

7

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Phosphorylation of the angiotensin II (AT1A) receptor carboxyl terminus: a role in receptor endocytosis

2 January 2024

https://api.crossref.org/works/10.1210/EN.2002-0135

8

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Regulation of angiotensin II type 1 (AT1) receptor function

2 January 2024

https://api.crossref.org/works/10.1210/EN.2002-0135

9

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Mechanisms and functions of AT(1) angiotensin receptor internalization

2 January 2024

https://api.crossref.org/works/10.1210/EN.2002-0135

10

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Crystal structure of rhodopsin: A G protein-coupled receptor

2 January 2024

https://api.crossref.org/works/10.1210/EN.2002-0135

11

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Mutational and computational analysis of the alpha(1b)-adrenergic receptor. Involvement of basic and hydrophobic residues in receptor activation and G protein coupling

2 January 2024

https://api.crossref.org/works/10.1210/EN.2002-0135

13

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Modulation of GDP release from transducin by the conserved Glu134-Arg135 sequence in rhodopsin

2 January 2024

https://api.crossref.org/works/10.1210/EN.2002-0135

14

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The activation process of the alpha1B-adrenergic receptor: potential role of protonation and hydrophobicity of a highly conserved aspartate

2 January 2024

https://api.crossref.org/works/10.1210/EN.2002-0135

17

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The effect of mutations in the DRY motif on the constitutive activity and structural instability of the histamine H(2) receptor.

2 January 2024

https://api.crossref.org/works/10.1210/EN.2002-0135

19

1 reference

Mutations of the conserved DRS motif in the second intracellular loop of the gonadotropin-releasing hormone receptor affect expression, activation, and internalization

2 January 2024

https://api.crossref.org/works/10.1210/EN.2002-0135

20

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Lessons from constitutively active mutants of G protein-coupled receptors

2 January 2024

https://api.crossref.org/works/10.1210/EN.2002-0135

21

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Functional Microdomains in G-protein-coupled Receptors

2 January 2024

https://api.crossref.org/works/10.1210/EN.2002-0135

22

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A common step for signal transduction in G protein-coupled receptors

2 January 2024

https://api.crossref.org/works/10.1210/EN.2002-0135

24

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The function of a highly-conserved arginine residue in activation of the muscarinic M1 receptor

2 January 2024

https://api.crossref.org/works/10.1210/EN.2002-0135

25

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An arginine residue conserved in most G protein-coupled receptors is essential for the function of the m1 muscarinic receptor.

2 January 2024

https://api.crossref.org/works/10.1210/EN.2002-0135

26

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Mutagenesis and peptide analysis of the DRY motif in the alpha2A adrenergic receptor: evidence for alternate mechanisms in G protein-coupled receptors.

2 January 2024

https://api.crossref.org/works/10.1210/EN.2002-0135

27

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Theoretical study of the electrostatically driven step of receptor-G protein recognition

2 January 2024

https://api.crossref.org/works/10.1210/EN.2002-0135

28

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The second intracellular loop of the m5 muscarinic receptor is the switch which enables G-protein coupling

2 January 2024

https://api.crossref.org/works/10.1210/EN.2002-0135

29

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Effects of second intracellular loop mutations on signal transduction and internalization of the gonadotropin-releasing hormone receptor

2 January 2024

https://api.crossref.org/works/10.1210/EN.2002-0135

31

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Two distinct pathways for histamine H2 receptor down-regulation. H2 Leu124 --> Ala receptor mutant provides evidence for a cAMP-independent action of H2 agonists

2 January 2024

https://api.crossref.org/works/10.1210/EN.2002-0135

32

1 reference

Single amino acid substitutions and deletions that alter the G protein coupling properties of the V2 vasopressin receptor identified in yeast by receptor random mutagenesis

2 January 2024

https://api.crossref.org/works/10.1210/EN.2002-0135

33

1 reference

Domains for G-protein coupling in angiotensin II receptor type I: studies by site-directed mutagenesis

2 January 2024

https://api.crossref.org/works/10.1210/EN.2002-0135

34

1 reference

Role of the conserved DRY motif on G protein activation of rat angiotensin II receptor type 1A

2 January 2024

https://api.crossref.org/works/10.1210/EN.2002-0135

35

1 reference

Angiotensin II type 1 receptor-function affected by mutations in cytoplasmic loop CD

2 January 2024

https://api.crossref.org/works/10.1210/EN.2002-0135

36

1 reference

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

2 January 2024

https://api.crossref.org/works/10.1210/EN.2002-0135

38

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Beta-arrestin- and dynamin-dependent endocytosis of the AT1 angiotensin receptor.

2 January 2024

https://api.crossref.org/works/10.1210/EN.2002-0135

39

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A Conserved NPLFY Sequence Contributes to Agonist Binding and Signal Transduction but Is Not an Internalization Signal for the Type 1 Angiotensin II Receptor

2 January 2024

https://api.crossref.org/works/10.1210/EN.2002-0135

40

1 reference

The role of receptor kinases and arrestins in G protein-coupled receptor regulation

2 January 2024

https://api.crossref.org/works/10.1210/EN.2002-0135

41

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AT1 receptor mutant lacking heterotrimeric G protein coupling activates the Src-Ras-ERK pathway without nuclear translocation of ERKs.

2 January 2024

https://api.crossref.org/works/10.1210/EN.2002-0135

42

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Molecular basis of receptor/G-protein-coupling selectivity

2 January 2024

https://api.crossref.org/works/10.1210/EN.2002-0135

43

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Sequence alignment of the G-protein coupled receptor superfamily

2 January 2024

https://api.crossref.org/works/10.1210/EN.2002-0135

44

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Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes

2 January 2024

https://api.crossref.org/works/10.1210/EN.2002-0135

45

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beta-Arrestin scaffolding of the ERK cascade enhances cytosolic ERK activity but inhibits ERK-mediated transcription following angiotensin AT1a receptor stimulation

2 January 2024

https://api.crossref.org/works/10.1210/EN.2002-0135

46

1 reference

The C-terminal third intracellular loop of the rat AT1A angiotensin receptor plays a key role in G protein coupling specificity and transduction of the mitogenic signal

2 January 2024

https://api.crossref.org/works/10.1210/EN.2002-0135

47

1 reference

Structure-function relationships of the alpha1b-adrenergic receptor

2 January 2024

https://api.crossref.org/works/10.1210/EN.2002-0135

48

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Role of aromaticity of agonist switches of angiotensin II in the activation of the AT1 receptor

2 January 2024

https://api.crossref.org/works/10.1210/EN.2002-0135

49

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Systematic identification of mutations that constitutively activate the angiotensin II type 1A receptor by screening a randomly mutated cDNA library with an original pharmacological bioassay

2 January 2024

https://api.crossref.org/works/10.1210/EN.2002-0135

50

1 reference

In vitro mutagenesis and the search for structure-function relationships among G protein-coupled receptors

2 January 2024

https://api.crossref.org/works/10.1210/EN.2002-0135

51

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The probable arrangement of the helices in G protein-coupled receptors.

2 January 2024

https://api.crossref.org/works/10.1210/EN.2002-0135

52

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Rhodopsin mutants that bind but fail to activate transducin

2 January 2024

https://api.crossref.org/works/10.1210/EN.2002-0135

53

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Characterization of rhodopsin mutants that bind transducin but fail to induce GTP nucleotide uptake. Classification of mutant pigments by fluorescence, nucleotide release, and flash-induced light-scattering assays.

2 January 2024

https://api.crossref.org/works/10.1210/EN.2002-0135

54

1 reference

Binding of low affinity N-formyl peptide receptors to G protein. Characterization of a novel inactive receptor intermediate

2 January 2024

https://api.crossref.org/works/10.1210/EN.2002-0135

55

1 reference

Mutagenesis and modelling of the alpha(1b)-adrenergic receptor highlight the role of the helix 3/helix 6 interface in receptor activation.

2 January 2024

https://api.crossref.org/works/10.1210/EN.2002-0135

56

1 reference

The role of the aspartate-arginine-tyrosine triad in the m1 muscarinic receptor: mutations of aspartate 122 and tyrosine 124 decrease receptor expression but do not abolish signaling

2 January 2024

https://api.crossref.org/works/10.1210/EN.2002-0135

57

1 reference

Mutation of Asn111 in the third transmembrane domain of the AT1A angiotensin II receptor induces its constitutive activation.

2 January 2024

https://api.crossref.org/works/10.1210/EN.2002-0135

58

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The tyrosine within the NPXnY motif of the human angiotensin II type 1 receptor is involved in mediating signal transduction but is not essential for internalization.

2 January 2024

https://api.crossref.org/works/10.1210/EN.2002-0135

59

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Requirement of membrane-proximal amino acids in the carboxyl-terminal tail for expression of the rat AT1a angiotensin receptor.

2 January 2024

https://api.crossref.org/works/10.1210/EN.2002-0135

60

1 reference

A domain for G protein coupling in carboxyl-terminal tail of rat angiotensin II receptor type 1A

2 January 2024

https://api.crossref.org/works/10.1210/EN.2002-0135

61

1 reference

Apparent loss-of-function mutant GPCRs revealed as constitutively desensitized receptors

2 January 2024

https://api.crossref.org/works/10.1210/EN.2002-0135

62

1 reference

Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin

2 January 2024

https://api.crossref.org/works/10.1210/EN.2002-0135

63

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Review: Structural requirements for signalling and regulation of AT1-receptors

2 January 2024

https://api.crossref.org/works/10.1210/EN.2002-0135

64

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Mapping of the amino acids in the cytoplasmic loop connecting helices C and D in rhodopsin. Chemical reactivity in the dark state following single cysteine replacements

2 January 2024

https://api.crossref.org/works/10.1210/EN.2002-0135

65

1 reference

Mutations in the second cytoplasmic loop of the rat parathyroid hormone (PTH)/PTH-related protein receptor result in selective loss of PTH-stimulated phospholipase C activity

2 January 2024

https://api.crossref.org/works/10.1210/EN.2002-0135

66

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Different single receptor domains determine the distinct G protein coupling profiles of members of the vasopressin receptor family

2 January 2024

https://api.crossref.org/works/10.1210/EN.2002-0135

67

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Raf-1 kinase activation by angiotensin II in adrenal glomerulosa cells: roles of Gi, phosphatidylinositol 3-kinase, and Ca2+ influx

2 January 2024

https://api.crossref.org/works/10.1210/EN.2002-0135

68

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2 January 2024

Identifiers

DOI

10.1210/EN.2002-0135

1 reference

31 October 2017

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