Lessons from constitutively active mutants of G protein-coupled receptors (Q34825754)

4 August 2017

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title

Lessons from constitutively active mutants of G protein-coupled receptors (English)

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G protein-coupled receptor

4 August 2017

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author

Pierre Corvol

4

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Stéphanie Miserey-Lenkei

2

object named as

Stéphanie Miserey-Lenkei

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4 August 2017

Charles Parnot

1

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author name string

Sabine Bardin

3

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PubMed ID

12217490

4 August 2017

Eric Clauser

5

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4 August 2017

1 October 2002

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Trends in Endocrinology and Metabolism

4 August 2017

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4 August 2017

13

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4 August 2017

336-343

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4 August 2017

8

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Uncovering molecular mechanisms involved in activation of G protein-coupled receptors

4 August 2017

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Inverse, protean, and ligand-selective agonism: matters of receptor conformation

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Drug efficacy at G protein-coupled receptors

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Regions of the alpha 1-adrenergic receptor involved in coupling to phosphatidylinositol hydrolysis and enhanced sensitivity of biological function

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Collecting and harvesting biological data: the GPCRDB and NucleaRDB information systems

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Antagonists with negative intrinsic activity at delta opioid receptors coupled to GTP-binding proteins

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Constitutive activation of opsin: influence of charge at position 134 and size at position 296.

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7 January 2021

The activation process of the alpha1B-adrenergic receptor: potential role of protonation and hydrophobicity of a highly conserved aspartate

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7 January 2021

Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6.

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7 January 2021

Functional Microdomains in G-protein-coupled Receptors

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The role of the aspartate-arginine-tyrosine triad in the m1 muscarinic receptor: mutations of aspartate 122 and tyrosine 124 decrease receptor expression but do not abolish signaling

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7 January 2021

Crystal structure of rhodopsin: A G protein-coupled receptor

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7 January 2021

Constitutive activation of opsin by mutation of methionine 257 on transmembrane helix 6.

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7 January 2021

Mutation of Asn111 in the third transmembrane domain of the AT1A angiotensin II receptor induces its constitutive activation.

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7 January 2021

The conformational change responsible for AT1 receptor activation is dependent upon two juxtaposed asparagine residues on transmembrane helices III and VII.

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7 January 2021

Review: amino acid domains involved in constitutive activation of G-protein-coupled receptors

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7 January 2021

The ectodomain of the luteinizing hormone receptor interacts with exoloop 2 to constrain the transmembrane region: studies using chimeric human and fly receptors

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7 January 2021

Identification of a ligand-dependent switch within a muscarinic receptor

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7 January 2021

The second intracellular loop of the m5 muscarinic receptor is the switch which enables G-protein coupling

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7 January 2021

Constitutively active muscarinic receptors

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7 January 2021

Systematic identification of mutations that constitutively activate the angiotensin II type 1A receptor by screening a randomly mutated cDNA library with an original pharmacological bioassay

1 reference

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7 January 2021

Mutational and computational analysis of the alpha(1b)-adrenergic receptor. Involvement of basic and hydrophobic residues in receptor activation and G protein coupling

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7 January 2021

Genetic mapping of the human C5a receptor. Identification of transmembrane amino acids critical for receptor function

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Identification of a polar region in transmembrane domain 6 that regulates the function of the G protein-coupled alpha-factor receptor

1 reference

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7 January 2021

Structural instability of a constitutively active G protein-coupled receptor. Agonist-independent activation due to conformational flexibility

1 reference

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7 January 2021

Agonist-induced phosphorylation of the angiotensin II (AT(1A)) receptor requires generation of a conformation that is distinct from the inositol phosphate-signaling state

1 reference

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7 January 2021

Constitutive Activation of the Cyclic Adenosine 3',5'-Monophosphate Signaling Pathway by Parathyroid Hormone (PTH)/PTH-Related Peptide Receptors Mutated at the Two Loci for Jansen's Metaphyseal Chondrodysplasia

1 reference

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7 January 2021

Molecular characterization of the receptor-ligand complex for parathyroid hormone.

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7 January 2021

Selective and nonselective inverse agonists for constitutively active type-1 parathyroid hormone receptors: evidence for altered receptor conformations

1 reference

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7 January 2021

Mutations that induce constitutive activation and mutations that impair signal transduction modulate the basal and/or agonist-stimulated internalization of the Lutropin/Choriogonadotropin receptor

1 reference

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7 January 2021

Effect of activating and inactivating mutations on the phosphorylation and trafficking of the human lutropin/choriogonadotropin receptor

1 reference

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7 January 2021

A constitutively active mutant beta 2-adrenergic receptor is constitutively desensitized and phosphorylated

1 reference

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7 January 2021

Constitutive internalization of constitutively active agiotensin II AT(1A) receptor mutants is blocked by inverse agonists

1 reference

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7 January 2021

Role of the thrombin receptor's cytoplasmic tail in intracellular trafficking. Distinct determinants for agonist-triggered versus tonic internalization and intracellular localization

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7 January 2021

Visualization of G protein-coupled receptor trafficking with the aid of the green fluorescent protein. Endocytosis and recycling of cholecystokinin receptor type A

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7 January 2021

A constitutively active mutant thyrotropin-releasing hormone receptor is chronically down-regulated in pituitary cells: evidence using chlordiazepoxide as a negative antagonist

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7 January 2021

Up-regulation of the levels of expression and function of a constitutively active mutant of the hamster alpha1B-adrenoceptor by ligands that act as inverse agonists

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7 January 2021

Resolution of inverse agonist-induced up-regulation from constitutive activity of mutants of the alpha(1b)-adrenoceptor

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7 January 2021

Inverse agonism of histamine H2 antagonist accounts for upregulation of spontaneously active histamine H2 receptors

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7 January 2021

Mechanisms governing the activation and trafficking of yeast G protein-coupled receptors.

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7 January 2021

Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas

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7 January 2021

A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty

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7 January 2021

An activating mutation of the follicle-stimulating hormone receptor autonomously sustains spermatogenesis in a hypophysectomized man.

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7 January 2021

Rhodopsin mutation G90D and a molecular mechanism for congenital night blindness

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7 January 2021

A constitutively active mutant PTH-PTHrP receptor in Jansen-type metaphyseal chondrodysplasia

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7 January 2021

Pharmacological chaperones rescue cell-surface expression and function of misfolded V2 vasopressin receptor mutants

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7 January 2021

Targeted expression of constitutively active receptors for parathyroid hormone and parathyroid hormone-related peptide delays endochondral bone formation and rescues mice that lack parathyroid hormone-related peptide

1 reference

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7 January 2021

Myocardial expression of a constitutively active alpha 1B-adrenergic receptor in transgenic mice induces cardiac hypertrophy

1 reference

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7 January 2021

Ligand-induced overexpression of a constitutively active beta2-adrenergic receptor: pharmacological creation of a phenotype in transgenic mice

1 reference

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7 January 2021

Targeted alpha(1A)-adrenergic receptor overexpression induces enhanced cardiac contractility but not hypertrophy

1 reference

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7 January 2021

Progressive hypertrophy and heart failure in beta1-adrenergic receptor transgenic mice.

1 reference

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7 January 2021

Physiological effects of inverse agonists in transgenic mice with myocardial overexpression of the beta 2-adrenoceptor

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7 January 2021

Overexpression of angiotensin AT1 receptor transgene in the mouse myocardium produces a lethal phenotype associated with myocyte hyperplasia and heart block

1 reference

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7 January 2021

Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains

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7 January 2021

G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity

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7 January 2021

G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator

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7 January 2021

Activating Smoothened mutations in sporadic basal-cell carcinoma

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7 January 2021

10.1016/S1043-2760(02)00628-8

Identifiers

DOI

1 reference

4 August 2017

1 reference

PubMed ID

12217490