Enhanced Stat3 activation in POMC neurons provokes negative feedback inhibition of leptin and insulin signaling in obesity. (Q42459963)

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7 February 2020

title

Enhanced Stat3 activation in POMC neurons provokes negative feedback inhibition of leptin and insulin signaling in obesity (English)

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7 February 2020

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7 February 2020

André Kleinridders

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7 February 2020

author name string

Marianne B Ernst

1

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7 February 2020

Claudia M Wunderlich

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7 February 2020

Simon Hess

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7 February 2020

Moritz Paehler

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Andrea Mesaros

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Andreas Husch

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Heike Münzberg

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Brigitte Hampel

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Jens Alber

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7 February 2020

Peter Kloppenburg

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F Thomas Wunderlich

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Jens C Brüning

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language of work or name

English

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publication date

1 September 2009

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7 February 2020

published in

Journal of Neuroscience

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7 February 2020

volume

29

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7 February 2020

issue

37

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7 February 2020

page(s)

11582-11593

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7 February 2020

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12 December 2020

Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin

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12 December 2020

Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area.

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12 December 2020

The role of SOCS-3 in leptin signaling and leptin resistance

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12 December 2020

Activation of downstream signals by the long form of the leptin receptor

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12 December 2020

SOCS-3 is an insulin-induced negative regulator of insulin signaling

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12 December 2020

Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity

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12 December 2020

Role of brain insulin receptor in control of body weight and reproduction

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12 December 2020

SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985

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12 December 2020

Divergent roles of SHP-2 in ERK activation by leptin receptors

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12 December 2020

Constitutively activated Stat3 protects fibroblasts from serum withdrawal and UV-induced apoptosis and antagonizes the proapoptotic effects of activated Stat1

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12 December 2020

Transgenic complementation of leptin-receptor deficiency. I. Rescue of the obesity/diabetes phenotype of LEPR-null mice expressing a LEPR-B transgene

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12 December 2020

Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

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12 December 2020

Selective deletion of leptin receptor in neurons leads to obesity

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12 December 2020

Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis

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12 December 2020

Hypothalamic insulin signaling is required for inhibition of glucose production

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12 December 2020

Rapid generation of inducible mouse mutants

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12 December 2020

Role for neuronal insulin resistance in neurodegenerative diseases

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12 December 2020

Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation

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12 December 2020

Orexigen-sensitive NPY/AgRP pacemaker neurons in the hypothalamic arcuate nucleus

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12 December 2020

Role of hypothalamic melanocortin 3/4-receptors in mediating chronic cardiovascular, renal, and metabolic actions of leptin.

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12 December 2020

Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis

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12 December 2020

Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3.

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12 December 2020

Region-specific leptin resistance within the hypothalamus of diet-induced obese mice.

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12 December 2020

Feedback inhibition of leptin receptor/Jak2 signaling via Tyr1138 of the leptin receptor and suppressor of cytokine signaling 3.

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12 December 2020

Post-embryonic ablation of AgRP neurons in mice leads to a lean, hypophagic phenotype

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12 December 2020

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12 December 2020

NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates.

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12 December 2020

Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis

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12 December 2020

Cyclin D1 is transcriptionally regulated by and required for transformation by activated signal transducer and activator of transcription 3.

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12 December 2020

Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake

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12 December 2020

Diet-induced obesity alters AMP kinase activity in hypothalamus and skeletal muscle.

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12 December 2020

Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity

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12 December 2020

Central insulin action in energy and glucose homeostasis

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12 December 2020

Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells.

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12 December 2020

Inactivation of signal transducer and activator of transcription 3 in proopiomelanocortin (Pomc) neurons causes decreased pomc expression, mild obesity, and defects in compensatory refeeding

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12 December 2020

Constitutively activated Stat3 induces tumorigenesis and enhances cell motility of prostate epithelial cells through integrin beta 6

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12 December 2020

Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production

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12 December 2020

AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons

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12 December 2020

Heterogeneous effects of dopamine on highly localized, voltage-induced Ca2+ accumulation in identified motoneurons.

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12 December 2020

Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity.

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12 December 2020

Activation of Stat3 signaling in AgRP neurons promotes locomotor activity

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12 December 2020

PDK1 deficiency in POMC-expressing cells reveals FOXO1-dependent and -independent pathways in control of energy homeostasis and stress response

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12 December 2020

Central insulin action regulates peripheral glucose and fat metabolism in mice

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12 December 2020

Leptin reverses weight loss-induced changes in regional neural activity responses to visual food stimuli

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12 December 2020

The geometry of leptin action in the brain: more complicated than a simple ARC.

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12 December 2020

Low access resistance perforated patch recordings using amphotericin B.

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12 December 2020

Visualizing unstained neurons in living brain slices by infrared DIC-videomicroscopy.

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12 December 2020

IgE-mediated degranulation of mast cells does not require opening of ion channels

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12 December 2020

Muscarinic activation of ionic currents measured by a new whole-cell recording method

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12 December 2020

Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action

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12 December 2020

Nystatin perforated patch recording and its applications to analyses of intracellular mechanisms.

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12 December 2020

Transcriptional responses to polypeptide ligands: the JAK-STAT pathway

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12 December 2020

Regulation of STAT-dependent pathways by growth factors and cytokines.

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12 December 2020

Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus.

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12 December 2020

Divergent signaling capacities of the long and short isoforms of the leptin receptor

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12 December 2020

Identification of SOCS-3 as a potential mediator of central leptin resistance

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12 December 2020

Leptin and the regulation of body weight in mammals

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12 December 2020

Hypothalamic agouti-related protein messenger ribonucleic acid is inhibited by leptin and stimulated by fasting

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12 December 2020

10.1523/JNEUROSCI.5712-08.2009

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19759305%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19759305%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

PubMed publication ID

19759305

1 reference