A naturally occurring human Nedd4-2 variant displays impaired ENaC regulation in Xenopus laevis oocytes (Q42461529)

1 November 2017

title

A naturally occurring human Nedd4-2 variant displays impaired ENaC regulation in Xenopus laevis oocytes (English)

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1 November 2017

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Xenopus laevis oocyte

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3

Bruno Vogt

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Fatemeh Fouladkou

1

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Rasoul Alikhani-Koopaei

2

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Sandra Y Flores

4

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Laurence Malbert-Colas

5

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Marie-Christine Lecomte

6

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Johannes Loffing

7

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Felix J Frey

8

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Brigitte M Frey

9

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Olivier Staub

10

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publication date

12 May 2004

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American Journal of Physiology - Renal Physiology

1 November 2017

published in

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volume

287

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issue

3

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page(s)

F550-61

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Defective regulation of the epithelial Na+ channel by Nedd4 in Liddle's syndrome.

1 November 2017

cites work

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The serum and glucocorticoid kinase sgk increases the abundance of epithelial sodium channels in the plasma membrane of Xenopus oocytes

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Autosomal dominant orthostatic hypotensive disorder maps to chromosome 18q.

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Nedd4 mediates control of an epithelial Na+ channel in salivary duct cells by cytosolic Na+

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Common variant of human NEDD4L activates a cryptic splice site to form a frameshifted transcript

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sgk: an essential convergence point for peptide and steroid hormone regulation of ENaC-mediated Na+ transport

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The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel alpha,beta,gamma-ENaC

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Inhibition of the epithelial Na+ channel by interaction of Nedd4 with a PY motif deleted in Liddle's syndrome

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Hypertension caused by a truncated epithelial sodium channel gamma subunit: genetic heterogeneity of Liddle syndrome

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A de novo missense mutation of the beta subunit of the epithelial sodium channel causes hypertension and Liddle syndrome, identifying a proline-rich segment critical for regulation of channel activity

21 January 2018

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The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel

21 January 2018

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All three WW domains of murine Nedd4 are involved in the regulation of epithelial sodium channels by intracellular Na+

21 January 2018

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Hormone-regulated transepithelial Na+ transport in mammalian CCD cells requires SGK1 expression

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A novel mouse Nedd4 protein suppresses the activity of the epithelial Na+ channel

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Muscle metaboreflex control is diminished in normotensive obese women

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Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2

21 January 2018

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Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase

21 January 2018

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Linkage of essential hypertension to chromosome 18q.

21 January 2018

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Aldosterone induces rapid apical translocation of ENaC in early portion of renal collecting system: possible role of SGK.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Novel isoforms of the beta and gamma subunits of the Xenopus epithelial Na channel provide information about the amiloride binding site and extracellular sodium sensing

21 January 2018

1 reference

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The activity of the epithelial sodium channel is regulated by clathrin-mediated endocytosis

21 January 2018

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Liddle's syndrome: heritable human hypertension caused by mutations in the beta subunit of the epithelial sodium channel

21 January 2018

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Use of Xenopus oocytes for the functional expression of plasma membrane proteins

21 January 2018

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Multiple WW domains, but not the C2 domain, are required for inhibition of the epithelial Na+ channel by human Nedd4

21 January 2018

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Serum and glucocorticoid-regulated kinase modulates Nedd4-2-mediated inhibition of the epithelial Na+ channel

21 January 2018

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Mechanism by which Liddle's syndrome mutations increase activity of a human epithelial Na+ channel

21 January 2018

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Relative contribution of Nedd4 and Nedd4-2 to ENaC regulation in epithelia determined by RNA interference

21 January 2018

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Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination

21 January 2018

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SGK integrates insulin and mineralocorticoid regulation of epithelial sodium transport

21 January 2018

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Impaired renal Na(+) retention in the sgk1-knockout mouse

21 January 2018

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10.1152/AJPRENAL.00353.2003

21 January 2018

Identifiers

DOI

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1 November 2017

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