Long-lasting rescue of age-associated deficits in cognition and the CNS cholinergic phenotype by a partial agonist peptidomimetic ligand of TrkA. (Q42467645)

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English	Long-lasting rescue of age-associated deficits in cognition and the CNS cholinergic phenotype by a partial agonist peptidomimetic ligand of TrkA.	scientific article

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Europe PubMed Central

1 November 2017

Long-lasting rescue of age-associated deficits in cognition and the CNS cholinergic phenotype by a partial agonist peptidomimetic ligand of TrkA (English)

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12 May 2020

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Rémi Quirion

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H Uri Saragovi

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12 May 2020

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Martin A Bruno

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12 May 2020

Paul B S Clarke

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12 May 2020

Alicia Seltzer

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12 May 2020

A Claudio Cuello

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publication date

1 September 2004

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Journal of Neuroscience

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12 May 2020

24

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8009-8018

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37

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12 May 2020

A nerve growth factor mimetic TrkA antagonist causes withdrawal of cortical cholinergic boutons in the adult rat.

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https://pubmed.ncbi.nlm.nih.gov/15371501

12 December 2020

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p75NTR: A study in contrasts

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https://pubmed.ncbi.nlm.nih.gov/15371501

12 December 2020

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Neuromodulation: acetylcholine and memory consolidation.

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https://pubmed.ncbi.nlm.nih.gov/15371501

12 December 2020

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Neurotrophin dependence mediated by p75NTR: contrast between rescue by BDNF and NGF.

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https://pubmed.ncbi.nlm.nih.gov/15371501

12 December 2020

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A designed peptidomimetic agonistic ligand of TrkA nerve growth factor receptors.

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https://pubmed.ncbi.nlm.nih.gov/15371501

12 December 2020

based on heuristic

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Development of pharmacological agents for targeting neurotrophins and their receptors

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https://pubmed.ncbi.nlm.nih.gov/15371501

12 December 2020

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Reduction in TrkA-immunoreactive neurons is not associated with an overexpression of galaninergic fibers within the nucleus basalis in Down's syndrome

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https://pubmed.ncbi.nlm.nih.gov/15371501

12 December 2020

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Increased CSF levels of nerve growth factor in patients with Alzheimer's disease

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https://pubmed.ncbi.nlm.nih.gov/15371501

12 December 2020

based on heuristic

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Nerve growth factor treatment in dementia

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https://pubmed.ncbi.nlm.nih.gov/15371501

12 December 2020

based on heuristic

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Neurotrophin signal transduction in the nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/15371501

12 December 2020

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Cell surface Trk receptors mediate NGF-induced survival while internalized receptors regulate NGF-induced differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15371501

12 December 2020

based on heuristic

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Alterations in neurotrophins and neurotrophin receptors in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15371501

12 December 2020

based on heuristic

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Loss of nucleus basalis neurons containing trkA immunoreactivity in individuals with mild cognitive impairment and early Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15371501

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p75 Co-receptors regulate ligand-dependent and ligand-independent Trk receptor activation, in part by altering Trk docking subdomains.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15371501

12 December 2020

based on heuristic

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Nerve growth factor signaling, neuroprotection, and neural repair

1 reference

https://pubmed.ncbi.nlm.nih.gov/15371501

12 December 2020

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Receptor binding, internalization, and retrograde transport of neurotrophic factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/15371501

12 December 2020

based on heuristic

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Cholinergic nerve terminals establish classical synapses in the rat cerebral cortex: synaptic pattern and age-related atrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/15371501

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of basal forebrain P75(NTR) immunoreactivity in subjects with mild cognitive impairment and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15371501

12 December 2020

based on heuristic

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Aging causes a preferential loss of cholinergic innervation of characterized neocortical pyramidal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/15371501

12 December 2020

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Does potency predict clinical efficacy? Illustration through an antihistamine model

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https://pubmed.ncbi.nlm.nih.gov/15371501

12 December 2020

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New templates for syntheses of ring-fused, C(10) beta-turn peptidomimetics leading to the first reported small-molecule mimic of neurotrophin-3.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15371501

12 December 2020

based on heuristic

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Small molecule peptidomimetic ligands of neurotrophin receptors, identifying binding sites, activation sites and regulatory sites

1 reference

https://pubmed.ncbi.nlm.nih.gov/15371501

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Theta-frequency synaptic potentiation in CA1 in vitro distinguishes cognitively impaired from unimpaired aged Fischer 344 rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15371501

12 December 2020

based on heuristic

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Nerve Growth Factor: Structure, Function and Therapeutic Implications for Alzheimers Disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15371501

12 December 2020

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Long-term effects of BIBN-99, a selective muscarinic M2 receptor antagonist, on improving spatial memory performance in aged cognitively impaired rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/15371501

12 December 2020

based on heuristic

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Automatic recognition of explorative strategies in the Morris water maze

1 reference

https://pubmed.ncbi.nlm.nih.gov/15371501

12 December 2020

based on heuristic

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ProNGF: a neurotrophic or an apoptotic molecule?

1 reference

https://pubmed.ncbi.nlm.nih.gov/15371501

12 December 2020

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The nerve growth factor precursor proNGF exhibits neurotrophic activity but is less active than mature nerve growth factor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15371501

12 December 2020

based on heuristic

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Reduction of cortical TrkA but not p75(NTR) protein in early-stage Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15371501

12 December 2020

based on heuristic

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Nerve growth factor-induced synaptogenesis and hypertrophy of cortical cholinergic terminals

1 reference

https://pubmed.ncbi.nlm.nih.gov/15371501

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In Vitro Susceptibility vs. In Vivo Efficacy of Various Antimicrobial Agents against the Bacteroides fragilis Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/15371501

12 December 2020

based on heuristic

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Hypothalamic-pituitary-adrenal activity in aged, cognitively impaired and cognitively unimpaired rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/15371501

12 December 2020

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Fluconazole and other azoles: translation of in vitro activity to in vivo and clinical efficacy

1 reference

https://pubmed.ncbi.nlm.nih.gov/15371501

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determinants of efficacy and toxicity of aminoglycosides

1 reference

https://pubmed.ncbi.nlm.nih.gov/15371501

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronotrophic factors in cellular functional and cognitive repair of adult brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/15371501

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An improved device for continuous intraventricular infusions prevents the introduction of pump-derived toxins and increases the effectiveness of NGF treatments

1 reference

https://pubmed.ncbi.nlm.nih.gov/15371501

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Linker Scaffold to Present Dimers of Pharmacophores Prepared by Solid-Phase Syntheses

1 reference

https://pubmed.ncbi.nlm.nih.gov/15371501

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Morphological response of axotomized septal neurons to nerve growth factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/15371501

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15371501

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cholinergic hypothesis of geriatric memory dysfunction

1 reference

https://pubmed.ncbi.nlm.nih.gov/15371501

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptic loss in cognitively impaired aged rats is ameliorated by chronic human nerve growth factor infusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/15371501

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotrophins and neuronal plasticity

1 reference

https://pubmed.ncbi.nlm.nih.gov/15371501

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cholinergic markers in aged cognitively impaired Long-Evans rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/15371501

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotrophic factor therapy for nervous system degenerative diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/15371501

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological characterization of nerve growth factor and/or monosialoganglioside GM1 effects on cholinergic markers in the adult lesioned brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/15371501

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lay-offs follow suspension of clinical trials of protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/15371501

12 December 2020

based on heuristic

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Neurotrophic factors enter the clinic.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15371501

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nerve growth factor and the monosialoganglioside GM1: analogous and different in vivo effects on biochemical, morphological, and behavioral parameters of adult cortically lesioned rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15371501

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotrophins and their receptors--current concepts and implications for neurologic disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15371501

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of the putative vesicular acetylcholine transporter in rat brain and localization in cholinergic synaptic vesicles

1 reference

https://pubmed.ncbi.nlm.nih.gov/15371501

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physiology of the neurotrophins

1 reference

https://pubmed.ncbi.nlm.nih.gov/15371501

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nerve growth factor mRNA and protein levels measured in the same tissue from normal and Alzheimer's disease parietal cortex.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15371501

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of nerve growth factor on spatial recent memory in aged rats persist after discontinuation of treatment.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15371501

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduction in p140-TrkA receptor protein within the nucleus basalis and cortex in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15371501

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Optimal nerve growth factor trophic signals mediated by synergy of TrkA and p75 receptor-specific ligands.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15371501

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Carrier mediated delivery of NGF: alterations in basal forebrain neurons in aged rats revealed using antibodies against low and high affinity NGF receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/15371501

12 December 2020

based on heuristic

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Saquinavir. Clinical pharmacology and efficacy

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https://pubmed.ncbi.nlm.nih.gov/15371501

12 December 2020

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A TrkA-selective, fast internalizing nerve growth factor-antibody complex induces trophic but not neuritogenic signals

1 reference

https://pubmed.ncbi.nlm.nih.gov/15371501

12 December 2020

based on heuristic

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Identifiers

10.1523/JNEUROSCI.1508-04.2004

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6729798&resulttype=core&format=json

12 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6729798&resulttype=core&format=json

12 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6729798&resulttype=core&format=json

12 May 2020

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