Dual regulation of T cell receptor-mediated signaling by oncogenic Cbl mutant 70Z. (Q42467870)

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12 December 2019

title

Dual regulation of T cell receptor-mediated signaling by oncogenic Cbl mutant 70Z (English)

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12 December 2019

4

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12 December 2019

author name string

Z Zhang

series ordinal

1

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12 December 2019

C Elly

series ordinal

2

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12 December 2019

A Altman

series ordinal

3

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12 December 2019

language of work or name

English

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publication date

1 February 1999

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Journal of Biological Chemistry

12 December 2019

published in

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12 December 2019

volume

274

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12 December 2019

issue

8

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12 December 2019

page(s)

4883-4889

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Signal transduction by lymphocyte antigen receptors

12 December 2019

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The proto-oncogene product c-Cbl becomes tyrosine phosphorylated by stimulation with GM-CSF or Epo and constitutively binds to the SH3 domain of Grb2/Ash in human hematopoietic cells

21 January 2018

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p120cbl is a cytosolic adapter protein that associates with phosphoinositide 3-kinase in response to epidermal growth factor in PC12 and other cells

21 January 2018

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Specific association of the beta isoform of the p85 subunit of phosphatidylinositol-3 kinase with the proto-oncogene c-cbl

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Oct-1 protein promotes functional transcription complex assembly on the mouse mammary tumor virus promoter

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Crkl is complexed with tyrosine-phosphorylated Cbl in Ph-positive leukemia

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The product of the cbl oncogene forms stable complexes in vivo with endogenous Crk in a tyrosine phosphorylation-dependent manner

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Crk interacts with tyrosine-phosphorylated p116 upon T cell activation

21 January 2018

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Interactions of Cbl with two adapter proteins, Grb2 and Crk, upon T cell activation

21 January 2018

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Sos, Vav, and C3G participate in B cell receptor-induced signaling pathways and differentially associate with Shc-Grb2, Crk, and Crk-L adaptors

21 January 2018

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B cell antigen receptor signaling induces the formation of complexes containing the Crk adapter proteins

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Activation-modulated association of 14-3-3 proteins with Cbl in T cells

21 January 2018

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Serine phosphorylation of Cbl induced by phorbol ester enhances its association with 14-3-3 proteins in T cells via a novel serine-rich 14-3-3-binding motif

21 January 2018

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Association of tyrosine protein kinase Zap-70 with the protooncogene product p120c-cbl in T lymphocytes

21 January 2018

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p120cbl is a major substrate of tyrosine phosphorylation upon B cell antigen receptor stimulation and interacts in vivo with Fyn and Syk tyrosine kinases, Grb2 and Shc adaptors, and the p85 subunit of phosphatidylinositol 3-kinase

21 January 2018

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Characterization of Cbl tyrosine phosphorylation and a Cbl-Syk complex in RBL-2H3 cells

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A novel phosphotyrosine-binding domain in the N-terminal transforming region of Cbl interacts directly and selectively with ZAP-70 in T cells

21 January 2018

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The Cbl phosphotyrosine-binding domain selects a D(N/D)XpY motif and binds to the Tyr292 negative regulatory phosphorylation site of ZAP-70.

21 January 2018

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Coordinated regulation of the tyrosine phosphorylation of Cbl by Fyn and Syk tyrosine kinases

21 January 2018

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Distinct tyrosine phosphorylation sites in ZAP-70 mediate activation and negative regulation of antigen receptor function

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.274.8.4883

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9988730%20AND%20SRC:MED&resulttype=core&format=json

12 December 2019

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