Metallothionein alleviates cardiac contractile dysfunction induced by insulin resistance: role of Akt phosphorylation, PTB1B, PPARgamma and c-Jun. (Q42484209)

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scientific article published on 20 September 2005

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English	Metallothionein alleviates cardiac contractile dysfunction induced by insulin resistance: role of Akt phosphorylation, PTB1B, PPARgamma and c-Jun.	scientific article published on 20 September 2005

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scholarly article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16172869%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

Metallothionein alleviates cardiac contractile dysfunction induced by insulin resistance: role of Akt phosphorylation, PTB1B, PPARgamma and c-Jun (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16172869%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

phosphorylation

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inferred from title

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insulin resistance

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4

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7 January 2020

author name string

C X Fang

1

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7 January 2020

F Dong

2

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7 January 2020

B H Ren

3

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7 January 2020

J Ren

5

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7 January 2020

publication date

20 September 2005

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7 January 2020

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7 January 2020

48

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7 January 2020

11

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7 January 2020

2412-2421

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7 January 2020

https://scigraph.springernature.com/pub.10.1007/s00125-005-1940-y

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Mitogen-activated protein kinase kinase inhibition does not block the stimulation of glucose utilization by insulin

1 reference

https://pubmed.ncbi.nlm.nih.gov/16172869

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular mechanisms of insulin resistance that impact cardiovascular biology

1 reference

https://pubmed.ncbi.nlm.nih.gov/16172869

12 December 2020

based on heuristic

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Metallothionein prevents diabetes-induced deficits in cardiomyocytes by inhibiting reactive oxygen species production

1 reference

https://pubmed.ncbi.nlm.nih.gov/16172869

12 December 2020

based on heuristic

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Different types of postinsulin receptor defects contribute to insulin resistance in hearts of obese Zucker rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/16172869

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress and diabetic cardiomyopathy: a brief review

1 reference

https://pubmed.ncbi.nlm.nih.gov/16172869

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cardiovascular complications of non-insulin-dependent diabetes: the JCR:LA-cp rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16172869

12 December 2020

based on heuristic

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Hyperglycemia and insulin resistance: possible mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/16172869

12 December 2020

based on heuristic

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Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/16172869

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-fructose diet decreases catalase mRNA levels in rat tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/16172869

12 December 2020

based on heuristic

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Abrogation of oxidative stress improves insulin sensitivity in the Ren-2 rat model of tissue angiotensin II overexpression

1 reference

https://pubmed.ncbi.nlm.nih.gov/16172869

12 December 2020

based on heuristic

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Amino acids and leucine allow insulin activation of the PKB/mTOR pathway in normal adipocytes treated with wortmannin and in adipocytes from db/db mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16172869

12 December 2020

based on heuristic

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Overexpression of metallothionein reduces diabetic cardiomyopathy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16172869

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of superoxide generation and associated nitrosative damage is involved in metallothionein prevention of diabetic cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/16172869

12 December 2020

based on heuristic

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Transgenic overexpression of protein-tyrosine phosphatase 1B in muscle causes insulin resistance, but overexpression with leukocyte antigen-related phosphatase does not additively impair insulin action

1 reference

https://pubmed.ncbi.nlm.nih.gov/16172869

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myocardial function and energy substrate metabolism in the insulin-resistant JCR:LA corpulent rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/16172869

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cardiomyocyte dysfunction in sucrose-fed rats is associated with insulin resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/16172869

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxisome proliferator-activated receptor gamma in diabetes and metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/16172869

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of insulin resistance and obesity in mice overexpressing cellular glutathione peroxidase

1 reference

https://pubmed.ncbi.nlm.nih.gov/16172869

12 December 2020

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Advanced glycation end product-induced peroxisome proliferator-activated receptor gamma gene expression in the cultured mesangial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16172869

12 December 2020

based on heuristic

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Prediabetic insulin resistance is not permissive to the development of cardiac resistance to insulin-like growth factor I in ventricular myocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16172869

12 December 2020

based on heuristic

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Oxidative stress activates the plasminogen activator inhibitor type 1 (PAI-1) promoter through an AP-1 response element and cooperates with insulin for additive effects on PAI-1 transcription

1 reference

https://pubmed.ncbi.nlm.nih.gov/16172869

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of a dominant-negative Ras mutant does not affect stimulation of glucose uptake and glycogen synthesis by insulin

1 reference

https://pubmed.ncbi.nlm.nih.gov/16172869

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abnormal mechanical function in diabetes: relation to myocardial calcium handling.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16172869

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathophysiology of insulin resistance in human disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16172869

12 December 2020

based on heuristic

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Insulin resistance induces hyperleptinemia, cardiac contractile dysfunction but not cardiac leptin resistance in ventricular myocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16172869

12 December 2020

based on heuristic

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Pathophysiology and pharmacological treatment of insulin resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/16172869

12 December 2020

based on heuristic

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Regulation of insulin receptor substrate-1 in liver and muscle of animal models of insulin resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/16172869

12 December 2020

based on heuristic

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Impaired cardiac efficiency and increased fatty acid oxidation in insulin-resistant ob/ob mouse hearts.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16172869

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sucrose-induced cardiomyocyte dysfunction is both preventable and reversible with clinically relevant treatments

1 reference

https://pubmed.ncbi.nlm.nih.gov/16172869

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced contractile response to insulin and IGF-I in ventricular myocytes from genetically obese Zucker rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/16172869

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signaling pathways: the benefits of good communication

1 reference

https://pubmed.ncbi.nlm.nih.gov/16172869

12 December 2020

based on heuristic

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Impaired cardiac function and IGF-I response in myocytes from calmodulin-diabetic mice: role of Akt and RhoA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16172869

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defects in insulin secretion and insulin action in non-insulin-dependent diabetes mellitus are inherited. Metabolic studies on offspring of diabetic probands

1 reference

https://pubmed.ncbi.nlm.nih.gov/16172869

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxisome proliferator-activated receptor (PPAR) alpha and PPARbeta/delta, but not PPARgamma, modulate the expression of genes involved in cardiac lipid metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/16172869

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase B in the diabetic heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/16172869

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16172869

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increases in insulin-like growth factor-1 level and peroxidative damage after gestational ethanol exposure in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/16172869

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defect in skeletal muscle phosphatidylinositol-3-kinase in obese insulin-resistant mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16172869

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diabetes rapidly induces contractile dysfunctions in isolated ventricular myocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16172869

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypertension and insulin disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/16172869

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms underlying depressed Na+/Ca2+ exchanger activity in the diabetic heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/16172869

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Type I and II models of diabetes produce different modifications of K+ currents in rat heart: role of insulin

1 reference

https://pubmed.ncbi.nlm.nih.gov/16172869

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of metallothionein in the heart of transgenic mice suppresses doxorubicin cardiotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16172869

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of IR/PTP1B interaction and downstream signaling in insulin sensitive tissues of MSG-rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/16172869

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/16172869

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High glucose induces cardiac insulin-like growth factor I resistance in ventricular myocytes: role of Akt and ERK activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16172869

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of insulin signaling through reversible oxidation of the protein-tyrosine phosphatases TC45 and PTP1B.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16172869

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diabetic cardiomyopathy: do women differ from men?

1 reference

https://pubmed.ncbi.nlm.nih.gov/16172869

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of paradoxical observations on the association between leptin and insulin resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/16172869

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxisome proliferator-activated receptor γ in diabetes and metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/16172869

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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