The majority of infiltrating CD8 T lymphocytes in multiple sclerosis lesions is insensitive to enhanced PD-L1 levels on CNS cells. (Q42484597)

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23 January 2020

title

The majority of infiltrating CD8 T lymphocytes in multiple sclerosis lesions is insensitive to enhanced PD-L1 levels on CNS cells (English)

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23 January 2020

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3

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23 January 2020

Nathalie Arbour

series ordinal

4

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23 January 2020

author name string

Camille L Pittet

series ordinal

1

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23 January 2020

Jia Newcombe

series ordinal

2

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23 January 2020

publication date

28 February 2011

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23 January 2020

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23 January 2020

volume

59

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23 January 2020

page(s)

841-856

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23 January 2020

issue

5

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Clonal expansions of CD8(+) T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction

23 January 2020

cites work

1 reference

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Coexpression of PD-1, 2B4, CD160 and KLRG1 on exhausted HCV-specific CD8+ T cells is linked to antigen recognition and T cell differentiation

21 January 2018

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Tissue-specific differences in PD-1 and PD-L1 expression during chronic viral infection: implications for CD8 T-cell exhaustion

21 January 2018

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PD-1:PD-L inhibitory pathway affects both CD4(+) and CD8(+) T cells and is overcome by IL-2

21 January 2018

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PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

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Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation

21 January 2018

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Pathogenic CD8(+) T cells in multiple sclerosis

21 January 2018

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Expression of major histocompatibility complex class I molecules on the different cell types in multiple sclerosis lesions.

21 January 2018

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Oligoclonal expansion of memory CD8+ T cells in cerebrospinal fluid from multiple sclerosis patients

21 January 2018

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Multiple sclerosis: T-cell receptor expression in distinct brain regions

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PD-1 and its ligands in tolerance and immunity

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Tissue expression of PD-L1 mediates peripheral T cell tolerance.

21 January 2018

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The common gamma-chain cytokines IL-2, IL-7, IL-15, and IL-21 induce the expression of programmed death-1 and its ligands

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PD-1 regulates neural damage in oligodendroglia-induced inflammation

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Accelerated course of experimental autoimmune encephalomyelitis in PD-1-deficient central nervous system myelin mutants

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21 January 2018

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Microglial expression of the B7 family member B7 homolog 1 confers strong immune inhibition: implications for immune responses and autoimmunity in the CNS.

21 January 2018

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Contribution of CD8 T lymphocytes to the immuno-pathogenesis of multiple sclerosis and its animal models.

21 January 2018

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PD-L1 has distinct functions in hematopoietic and nonhematopoietic cells in regulating T cell responses during chronic infection in mice.

21 January 2018

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21 January 2018

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Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor

21 January 2018

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21 January 2018

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B7-H1 restricts neuroantigen-specific T cell responses and confines inflammatory CNS damage: implications for the lesion pathogenesis of multiple sclerosis

21 January 2018

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Target-dependent B7-H1 regulation contributes to clearance of central nervous system infection and dampens morbidity.

21 January 2018

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Tumour necrosis factor alpha induces rapid reduction in AMPA receptor-mediated calcium entry in motor neurones by increasing cell surface expression of the GluR2 subunit: relevance to neurodegeneration

21 January 2018

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Enhanced PD-1 expression by T cells in cerebrospinal fluid does not reflect functional exhaustion during chronic human immunodeficiency virus type 1 infection

21 January 2018

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NKG2D-mediated cytotoxicity toward oligodendrocytes suggests a mechanism for tissue injury in multiple sclerosis.

21 January 2018

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Critical role of the programmed death-1 (PD-1) pathway in regulation of experimental autoimmune encephalomyelitis

21 January 2018

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Multiple sclerosis: brain-infiltrating CD8+ T cells persist as clonal expansions in the cerebrospinal fluid and blood

21 January 2018

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Tumour Necrosis Factor Modulation for Treatment of Alzheimerʼs Disease

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21 January 2018

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PD-1 Expression in Acute Hepatitis C Virus (HCV) Infection Is Associated with HCV-Specific CD8 Exhaustion

21 January 2018

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Down-modulation of programmed death 1 alters regulatory T cells and promotes experimental autoimmune encephalomyelitis

21 January 2018

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Kupffer cell suppression of CD8+ T cells in human hepatocellular carcinoma is mediated by B7-H1/programmed death-1 interactions

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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12 December 2020

Endothelial expression of PD‐L1 and PD‐L2 down‐regulates CD8+ T cell activation and cytolysis

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12 December 2020

The inhibitory pathway PD-1/PD-1 ligands is upregulated in rheumatoid synovium and regulates peripheral T cell responses in human and murine arthritis

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12 December 2020

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12 December 2020

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Differential role of programmed death-ligand 1 [corrected] and programmed death-ligand 2 [corrected] in regulating the susceptibility and chronic progression of experimental autoimmune encephalomyelitis

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Identifiers

DOI

10.1002/GLIA.21158

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21360758%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

0 references

1 reference