AKT1 provides an essential survival signal required for differentiation and stratification of primary human keratinocytes (Q42491656)

1 November 2017

title

AKT1 provides an essential survival signal required for differentiation and stratification of primary human keratinocytes (English)

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1 November 2017

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Barry R Thrash

1

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1 November 2017

Craig W Menges

series ordinal

2

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1 November 2017

Robert H Pierce

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3

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1 November 2017

Dennis J McCance

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4

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1 November 2017

language of work or name

English

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publication date

3 March 2006

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Journal of Biological Chemistry

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published in

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volume

281

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1 November 2017

issue

17

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1 November 2017

page(s)

12155-12162

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Getting under the skin of epidermal morphogenesis

1 November 2017

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p63 is the molecular switch for initiation of an epithelial stratification program

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Positive feedback regulation between Akt2 and MyoD during muscle differentiation. Cloning of Akt2 promoter

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Cell cycle withdrawal promotes myogenic induction of Akt, a positive modulator of myocyte survival

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Human papillomavirus type 16 alters human epithelial cell differentiation in vitro

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Hoxb13 up-regulates transglutaminase activity and drives terminal differentiation in an epidermal organotypic model

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Akt2 mRNA is highly expressed in embryonic brown fat and the AKT2 kinase is activated by insulin

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Transient activation of FOXN1 in keratinocytes induces a transcriptional programme that promotes terminal differentiation: contrasting roles of FOXN1 and Akt.

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Phosphoinositide 3-kinase signaling to Akt promotes keratinocyte differentiation versus death.

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Cellular survival: a play in three Akts

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Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene

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Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

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Caspase activation in the terminal differentiation of human epidermal keratinocytes

21 January 2018

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Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten

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Overexpression of insulin-like growth factor-1 induces hyperplasia, dermal abnormalities, and spontaneous tumor formation in transgenic mice.

21 January 2018

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NF-kappaB blockade and oncogenic Ras trigger invasive human epidermal neoplasia.

21 January 2018

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21 January 2018

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In vivo cooperation between Bcl-xL and the phosphoinositide 3-kinase-Akt signaling pathway for the protection of epidermal keratinocytes from apoptosis.

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Direct control of the Forkhead transcription factor AFX by protein kinase B

21 January 2018

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Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

21 January 2018

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NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

21 January 2018

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21 January 2018

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Activation of the protein kinase Akt/PKB by the formation of E-cadherin-mediated cell-cell junctions. Evidence for the association of phosphatidylinositol 3-kinase with the E-cadherin adhesion complex.

21 January 2018

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Phosphatidylinositol 3-kinase controls human intestinal epithelial cell differentiation by promoting adherens junction assembly and p38 MAPK activation.

21 January 2018

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Akt/PKB localisation and 3' phosphoinositide generation at sites of epithelial cell-matrix and cell-cell interaction

21 January 2018

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Evidence that apoptosis and terminal differentiation of epidermal keratinocytes are distinct processes

21 January 2018

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Phosphatidylinositol 3-Kinase Is a Key Regulator of Early Phase Differentiation in Keratinocytes

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M512116200

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1 November 2017

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