Smads mediate signaling of the TGFbeta superfamily in normal keratinocytes but are lost during skin chemical carcinogenesis (Q42503191)

1 November 2017

Smads mediate signaling of the TGFbeta superfamily in normal keratinocytes but are lost during skin chemical carcinogenesis (English)

1 reference

1 November 2017

1 reference

1 reference

He W

1

1 reference

1 November 2017

Cao T

2

1 reference

1 November 2017

Smith DA

3

1 reference

1 November 2017

Myers TE

4

1 reference

1 November 2017

Wang XJ

5

1 reference

1 November 2017

language of work or name

English

0 references

publication date

1 January 2001

1 reference

1 November 2017

1 reference

1 November 2017

20

1 reference

1 November 2017

4

1 reference

1 November 2017

471-483

1 reference

https://scigraph.springernature.com/pub.10.1038/sj.onc.1204117

1 November 2017

0 references

cites work

TbetaRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204117

Progressive dysplasia and aneuploidy are hallmarks of mouse skin papillomas: relevance to malignancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204117

Expression of a dominant negative type II TGF-beta receptor in mouse skin results in an increase in carcinoma incidence and an acceleration of carcinoma development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204117

Vitamin D metabolite production and function in keratinocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204117

Chemical skin carcinogenesis is prevented in mice by the induced expression of a TGF-beta related transgene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204117

Overexpression of bone morphogenetic protein-6 (BMP-6) in the epidermis of transgenic mice: inhibition or stimulation of proliferation depending on the pattern of transgene expression and formation of psoriatic lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204117

TGFbeta1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204117

Smad4 (homolog of human DPC4) and Smad2 (homolog of human JV18-1): candidates for murine lung tumor resistance and suppressor genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204117

Multistage carcinogenesis in mouse skin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204117

A single missense mutant of Smad3 inhibits activation of both Smad2 and Smad3, and has a dominant negative effect on TGF-beta signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204117

DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204117

SMAD destruction turns off signalling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204117

DPC4 gene mutation in colitis associated neoplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204117

Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204117

Smad6 inhibits signalling by the TGF-beta superfamily.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204117

Identification and functional characterization of a Smad binding element (SBE) in the JunB promoter that acts as a transforming growth factor-beta, activin, and bone morphogenetic protein-inducible enhancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204117

Molecular analyses of the 15q and 18q SMAD genes in pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204117

Signal transduction of the TGF-beta superfamily by Smad proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204117

Cooperation between SMAD and NF-kappaB in growth factor regulated type VII collagen gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204117

Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204117

A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204117

TGF-beta 1 and skin carcinogenesis: antiproliferative effect in vitro and TGF-beta 1 mRNA expression during epidermal hyperproliferation and multistage tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204117

Sp1, but not Sp3, functions to mediate promoter activation by TGF-beta through canonical Sp1 binding sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204117

IKK1-deficient mice exhibit abnormal development of skin and skeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204117

Transforming growth factor beta-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204117

Ubiquitin-dependent degradation of TGF-beta-activated smad2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204117

Genomic sequencing of DPC4 in the analysis of familial pancreatic carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204117

In situ hybridization analysis of ZPK gene expression during murine embryogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204117

Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204117

Altered expression of transforming growth factor-beta 1 mRNA and protein in mouse skin carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204117

Transforming growth factor-beta: potential common mechanisms mediating its effects on embryogenesis, inflammation-repair, and carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204117

Physiological actions and clinical applications of transforming growth factor-beta (TGF-beta).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204117

Regulated expression of differentiation-associated keratins in cultured epidermal cells detected by monospecific antibodies to unique peptides of mouse epidermal keratins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204117

Uncoordinated regulation of mRNA expression of the three isoforms of transforming growth factor-beta in the mouse skin carcinogenesis model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204117

Inhibition of skin development by overexpression of transforming growth factor beta 1 in the epidermis of transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204117

Dose- and time-dependent expression of transforming growth factor-beta 1 mRNA and protein in mouse epidermis and papillomas after repeated topical application of benzo[a]pyrene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204117

Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-beta signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204117

Limb and skin abnormalities in mice lacking IKKalpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204117

Expression of a dominant-negative type II transforming growth factor beta (TGF-beta) receptor in the epidermis of transgenic mice blocks TGF-beta-mediated growth inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204117

Development of gene-switch transgenic mice that inducibly express transforming growth factor beta1 in the epidermis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204117

Smad3-Smad4 and AP-1 complexes synergize in transcriptional activation of the c-Jun promoter by transforming growth factor beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204117

Smad5, a tumor suppressor candidate at 5q31.1, is hemizygously lost and not mutated in the retained allele in human leukemia cell line HL60.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204117

Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204117

Smad3 mutant mice develop metastatic colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204117

Smad proteins physically interact with calmodulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204117

Localized production of TGF-β mRNA in tumour promoter-stimulated mouse epidermis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204117

Transgenic mice as a model to study the role of TGF-beta-related molecules in hair follicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204117

7 January 2021

Targeted deletion of the TGF-beta 1 gene causes rapid progression to squamous cell carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204117

7 January 2021

Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204117

7 January 2021

In vivo effects of vitamin D on the proliferation and differentiation of rat keratinocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204117

7 January 2021

Somatic alterations of the DPC4 gene in human colorectal cancers in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204117

7 January 2021

Allelic losses on 18q21 are associated with progression and metastasis in human prostate cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204117

7 January 2021

Positive and negative modulation of vitamin D receptor function by transforming growth factor-beta signaling through smad proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204117

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1204117

1 reference

Dimensions Publication ID

1 November 2017

0 references

1 reference