Post-aggregation oxidation of mutant huntingtin controls the interactions between aggregates. (Q42519015)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22891249%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

title

Post-aggregation oxidation of mutant huntingtin controls the interactions between aggregates (English)

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11 February 2020

5

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11 February 2020

author name string

Yasushi Mitomi

1

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11 February 2020

Takao Nomura

2

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11 February 2020

Masaru Kurosawa

3

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11 February 2020

Nobuyuki Nukina

4

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11 February 2020

language of work or name

English

0 references

publication date

13 August 2012

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Journal of Biological Chemistry

11 February 2020

published in

1 reference

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11 February 2020

volume

287

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11 February 2020

issue

41

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11 February 2020

page(s)

34764-34775

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Physical chemistry of polyglutamine: intriguing tales of a monotonous sequence

11 February 2020

cites work

1 reference

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Local unfolding of Cu, Zn superoxide dismutase monomer determines the morphology of fibrillar aggregates

28 May 2018

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In vitro and in vivo aggregation of a fragment of huntingtin protein directly causes free radical production

28 May 2018

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Cysteine oxidation within N-terminal mutant huntingtin promotes oligomerization and delays clearance of soluble protein

28 May 2018

1 reference

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The aggregation-enhancing huntingtin N-terminus is helical in amyloid fibrils

28 May 2018

1 reference

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β2-microglobulin forms three-dimensional domain-swapped amyloid fibrils with disulfide linkages

28 May 2018

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Prion strain mutation determined by prion protein conformational compatibility and primary structure

28 May 2018

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Polyglutamine induced misfolding of huntingtin exon1 is modulated by the flanking sequences

28 May 2018

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Mutation-dependent polymorphism of Cu,Zn-superoxide dismutase aggregates in the familial form of amyotrophic lateral sclerosis

28 May 2018

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Methionine oxidation induces amyloid fibril formation by full-length apolipoprotein A-I.

28 May 2018

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Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice

28 May 2018

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Modulation of polyglutamine conformations and dimer formation by the N-terminus of huntingtin

28 May 2018

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The chaperonin TRiC blocks a huntingtin sequence element that promotes the conformational switch to aggregation

28 May 2018

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Secondary Structure of Huntingtin Amino-Terminal Region

28 May 2018

1 reference

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Phosphorylation of threonine 3: implications for Huntingtin aggregation and neurotoxicity

28 May 2018

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Distinct conformations of in vitro and in vivo amyloids of huntingtin-exon1 show different cytotoxicity

28 May 2018

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Design of anti- and pro-aggregation variants to assess the effects of methionine oxidation in human prion protein

28 May 2018

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Atomic structures of amyloid cross-beta spines reveal varied steric zippers

28 May 2018

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Mechanisms of copper ion mediated Huntington's disease progression

28 May 2018

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Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

28 May 2018

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Conformational change and assembly through edge beta strands in transthyretin and other amyloid proteins

28 May 2018

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Reading protein modifications with interaction domains

28 May 2018

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Disulfide cross-linked protein represents a significant fraction of ALS-associated Cu, Zn-superoxide dismutase aggregates in spinal cords of model mice

28 May 2018

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Normal huntingtin function: an alternative approach to Huntington's disease

28 May 2018

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Methionine oxidation, alpha-synuclein and Parkinson's disease

28 May 2018

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Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

28 May 2018

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Protein aggregation and neurodegenerative disease

28 May 2018

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Experimental therapeutics in transgenic mouse models of Huntington's disease

28 May 2018

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SUMO modification of Huntingtin and Huntington's disease pathology

28 May 2018

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Conformational variations in an infectious protein determine prion strain differences

28 May 2018

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28 May 2018

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Nuclear and neuropil aggregates in Huntington's disease: relationship to neuropathology.

28 May 2018

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Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

28 May 2018

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Oxidative damage and metabolic dysfunction in Huntington's disease: selective vulnerability of the basal ganglia.

28 May 2018

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

28 May 2018

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28 May 2018

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Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons

28 May 2018

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Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease

28 May 2018

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Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology

28 May 2018

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Metal ion-catalyzed oxidation of proteins: biochemical mechanism and biological consequences

28 May 2018

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On the role of methionine residues in the sequence-independent recognition of nonpolar protein surfaces

28 May 2018

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Light scattering from nucleated biological cells

28 May 2018

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Cross-seeding fibrillation of Q/N-rich proteins offers new pathomechanism of polyglutamine diseases

28 May 2018

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Polyglutamine disruption of the huntingtin exon 1 N terminus triggers a complex aggregation mechanism

16 August 2018

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Methionine sulfoxides on PrPSc: a prion-specific covalent signature

16 August 2018

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Sensitive biochemical aggregate detection reveals aggregation onset before symptom development in cellular and murine models of Huntington's disease

16 August 2018

1 reference

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Chronology of behavioral symptoms and neuropathological sequela in R6/2 Huntington's disease transgenic mice

16 August 2018

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Biochemical, ultrastructural, and reversibility studies on huntingtin filaments isolated from mouse and human brain.

16 August 2018

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Metal binding and oxidation of amyloid-beta within isolated senile plaque cores: Raman microscopic evidence

16 August 2018

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Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo

16 August 2018

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Cleavage pattern and emerging asymmetry of the mouse embryo.

16 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M112.387035

21 January 2018

Identifiers

DOI

10.1074/JBC.M112.387035

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22891249%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22891249%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

1 reference