Direct identification of tyrosine 474 as a regulatory phosphorylation site for the Akt protein kinase (Q42524332)

1 November 2017

Direct identification of tyrosine 474 as a regulatory phosphorylation site for the Akt protein kinase (English)

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1 November 2017

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4

Brian A Hemmings

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1 November 2017

Nelly Marmy Conus

1

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1 November 2017

Katherine M Hannan

series ordinal

2

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1 November 2017

Briony E Cristiano

series ordinal

3

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1 November 2017

Richard B Pearson

series ordinal

5

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1 November 2017

language of work or name

English

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publication date

30 July 2002

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Journal of Biological Chemistry

1 November 2017

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1 November 2017

277

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1 November 2017

41

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1 November 2017

38021-38028

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Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1 November 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203387200

The Croonian Lecture 1998. Identification of a protein kinase cascade of major importance in insulin signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203387200

Mechanism of activation and function of protein kinase B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203387200

Mechanisms and consequences of activation of protein kinase B/Akt

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203387200

Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203387200

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203387200

Vascular endothelial growth factor up-regulates ICAM-1 expression via the phosphatidylinositol 3 OH-kinase/AKT/Nitric oxide pathway and modulates migration of brain microvascular endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203387200

Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203387200

Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203387200

The Akt kinase signals directly to endothelial nitric oxide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203387200

Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203387200

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203387200

Akt signaling: linking membrane events to life and death decisions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203387200

Syk and Bruton's tyrosine kinase are required for B cell antigen receptor-mediated activation of the kinase Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203387200

Regulation of Akt/PKB activation by tyrosine phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203387200

Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203387200

Identification of tyrosine phosphorylation sites on 3-phosphoinositide-dependent protein kinase-1 and their role in regulating kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203387200

Differential regulation by calcium reveals distinct signaling requirements for the activation of Akt and p70S6k

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203387200

Phosphorylation of nuclear phospholipase C beta1 by extracellular signal-regulated kinase mediates the mitogenic action of insulin-like growth factor I

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203387200

Akt activation by growth factors is a multiple-step process: the role of the PH domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203387200

PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203387200

The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203387200

Effect of phosphoinositide-dependent kinase 1 on protein kinase B translocation and its subsequent activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203387200

Src family kinases mediate receptor-stimulated, phosphoinositide 3-kinase-dependent, tyrosine phosphorylation of dual adaptor for phosphotyrosine and 3-phosphoinositides-1 in endothelial and B cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203387200

Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203387200

Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203387200

Cellular signaling: pivoting around PDK-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203387200

The protooncogene TCL1 is an Akt kinase coactivator

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203387200

Posttranslational modifications of the 5'-AMP-activated protein kinase beta1 subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203387200

21 January 2018

Identifiers

DOI

10.1074/JBC.M203387200

1 reference

1 November 2017

1 reference