In vivo disruption of an Rb-E2F-Ezh2 signaling loop causes bladder cancer. (Q42550010)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25252918%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

title

In vivo disruption of an Rb-E2F-Ezh2 signaling loop causes bladder cancer (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25252918%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

author

Ramón García-Escudero

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25252918%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Marta Dueñas

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25252918%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Felipe Villacampa

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25252918%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Clotilde Costa

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25252918%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Marta Oteo

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25252918%20AND%20SRC:MED&resulttype=core&format=json

Miguel Angel Morcillo Alonso

19 February 2020

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25252918%20AND%20SRC:MED&resulttype=core&format=json

José Luis Rodríguez-Peralto

19 February 2020

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25252918%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Jesus M. Paramio

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25252918%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

17

Julien Sage

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25252918%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

author name string

Mirentxu Santos

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25252918%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Mónica Martínez-Fernández

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25252918%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Begoña Alfaya

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25252918%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Cristina Saiz-Ladera

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25252918%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

José Duarte

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25252918%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Victor Martínez

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25252918%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Mª José Gómez-Rodriguez

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25252918%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Mª Luisa Martín

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25252918%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Manoli Fernández

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25252918%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Patrick Viatour

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25252918%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Daniel Castellano

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25252918%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Federico de la Rosa

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25252918%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

language of work or name

English

0 references

publication date

24 September 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25252918%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25252918%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

volume

74

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25252918%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

issue

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25252918%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

page(s)

6565-6577

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25252918%20AND%20SRC:MED&resulttype=core&format=json

Whole-genome sequencing of bladder cancers reveals somatic CDKN1A mutations and clinicopathological associations with mutation burden

19 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233185

Comprehensive molecular characterization of urothelial bladder carcinoma

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233185

Skin Tumors Rb(eing) Uncovered.

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233185

Recurrent inactivation of STAG2 in bladder cancer is not associated with aneuploidy.

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233185

Prevalence and co-occurrence of actionable genomic alterations in high-grade bladder cancer

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233185

Advanced urothelial carcinoma: next-generation sequencing reveals diverse genomic alterations and targets of therapy

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233185

A novel tumor suppressor network in squamous malignancies

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233185

EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233185

A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233185

ICUD-EAU International Consultation on Bladder Cancer 2012: Non-muscle-invasive urothelial carcinoma of the bladder.

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233185

Mouse p53-deficient cancer models as platforms for obtaining genomic predictors of human cancer clinical outcomes

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233185

Combining molecular and pathologic data to prognosticate non-muscle-invasive bladder cancer

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233185

Integrated genomic and gene expression profiling identifies two major genomic circuits in urothelial carcinoma

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233185

EMT and induction of miR-21 mediate metastasis development in Trp53-deficient tumours

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233185

Stat3 activation in urothelial stem cells leads to direct progression to invasive bladder cancer

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233185

Exploring molecular genetics of bladder cancer: lessons learned from mouse models

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233185

Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233185

ChEA: transcription factor regulation inferred from integrating genome-wide ChIP-X experiments

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233185

Genome-wide association studies of bladder cancer risk: a field synopsis of progress and potential applications

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233185

Deficiency of pRb family proteins and p53 in invasive urothelial tumorigenesis.

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233185

Inactivation of p53 and Pten promotes invasive bladder cancer

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233185

Hematopoietic stem cell quiescence is maintained by compound contributions of the retinoblastoma gene family

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233185

Inactivation of the Rb pathway and overexpression of both isoforms of E2F3 are obligate events in bladder tumours with 6p22 amplification.

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233185

Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233185

Role of E2F3 expression in modulating cellular proliferation rate in human bladder and prostate cancer cells

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233185

Molecular subtypes of bladder cancer: Jekyll and Hyde or chalk and cheese?

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233185

Cellular basis of urothelial squamous metaplasia: roles of lineage heterogeneity and cell replacement

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233185

Expression levels of the EZH2 polycomb transcriptional repressor correlate with aggressiveness and invasive potential of bladder carcinomas

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233185

ONCOMINE: a cancer microarray database and integrated data-mining platform

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233185

Amplification and overexpression of E2F3 in human bladder cancer

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233185

EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233185

PIK3CA gene alterations in bladder cancer are frequent and associate with reduced recurrence in non-muscle invasive tumors

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233185

Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233185

A comprehensive immunohistochemical and molecular approach to the PI3K/AKT/mTOR (phosphoinositide 3-kinase/v-akt murine thymoma viral oncogene/mammalian target of rapamycin) pathway in bladder urothelial carcinoma.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233185

E2F1 loss induces spontaneous tumour development in Rb-deficient epidermis

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233185

CDKN2A homozygous deletion is associated with muscle invasion in FGFR3-mutated urothelial bladder carcinoma.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233185

Increased EZH2 protein expression is associated with invasive urothelial carcinoma of the bladder

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233185

Expression signature of E2F1 and its associated genes predict superficial to invasive progression of bladder tumors

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233185

Gene profiling approaches help to define the specific functions of retinoblastoma family in epidermis.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233185

Identification and validation of suitable endogenous reference genes for gene expression studies of human bladder cancer.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233185

FGFR3 and Ras gene mutations are mutually exclusive genetic events in urothelial cell carcinoma.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233185

Transcription factor E2F3 overexpressed in prostate cancer independently predicts clinical outcome

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233185

Unique and overlapping functions of pRb and p107 in the control of proliferation and differentiation in epidermis

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233185

E2F3 amplification and overexpression is associated with invasive tumor growth and rapid tumor cell proliferation in urinary bladder cancer

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233185

Identifying distinct classes of bladder carcinoma using microarrays.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233185

Differential expression of cell cycle regulators in phenotypic variants of transgenically induced bladder tumors: implications for tumor behavior

16 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25252918

12 December 2020

inferred from PubMed ID database lookup

Spontaneous Squamous Cell Carcinoma Induced by the Somatic Inactivation of Retinoblastoma and Trp53 Tumor Suppressors

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25252918

12 December 2020

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/25252918

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1158/0008-5472.CAN-14-1218

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25252918%20AND%20SRC:MED&resulttype=core&format=json

release_eozctxo3xrbnzpsyqy3bswp56a

19 February 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/eozctxo3xrbnzpsyqy3bswp56a

24 November 2022

mapped directly with Wikidata item

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25252918%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

PubMed publication ID

25252918

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25252918%20AND%20SRC:MED&resulttype=core&format=json