The role of gp130/IL-6 cytokines in the development of pulmonary fibrosis: critical determinants of disease susceptibility and progression? (Q42607396)

3 November 2017

The role of gp130/IL-6 cytokines in the development of pulmonary fibrosis: critical determinants of disease susceptibility and progression? (English)

1 reference

3 November 2017

1 reference

Darryl A Knight

1

1 reference

3 November 2017

Matthias Ernst

2

1 reference

3 November 2017

Gary P Anderson

3

1 reference

3 November 2017

Yuben P Moodley

4

1 reference

3 November 2017

Steven E Mutsaers

5

1 reference

3 November 2017

1 September 2003

1 reference

Pharmacology & Therapeutics

3 November 2017

1 reference

3 November 2017

99

1 reference

3 November 2017

3

1 reference

3 November 2017

327-338

1 reference

American Thoracic Society. Idiopathic pulmonary fibrosis: diagnosis and treatment. International consensus statement. American Thoracic Society (ATS), and the European Respiratory Society (ERS)

3 November 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Fibroblasts modulate intestinal secretory responses to inflammatory mediators

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Postnatally induced inactivation of gp130 in mice results in neurological, cardiac, hematopoietic, immunological, hepatic, and pulmonary defects

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Prognostic significance of histopathologic subsets in idiopathic pulmonary fibrosis

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

PDGF-A Signaling Is a Critical Event in Lung Alveolar Myofibroblast Development and Alveogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Reduced tumor necrosis factor-alpha and transforming growth factor-beta1 expression in the lungs of inbred mice that fail to develop fibroproliferative lesions consequent to asbestos exposure

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Suppression of SHP-2 and ERK signalling promotes self-renewal of mouse embryonic stem cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Leukemia inhibitory factor determines the growth status of injured adult sensory neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Global expression profiling of fibroblast responses to transforming growth factor-beta1 reveals the induction of inhibitor of differentiation-1 and provides evidence of smooth muscle cell phenotypic switching

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

LIF is an autocrine factor for sympathetic neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Specific inhibition of Stat3 signal transduction by PIAS3

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Oncostatin M, leukaemia-inhibitory factor and interleukin 6 trigger different effects on alpha1-proteinase inhibitor synthesis in human lung-derived epithelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Future research directions in idiopathic pulmonary fibrosis: summary of a National Heart, Lung, and Blood Institute working group.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Airway epithelial cell expression of interleukin-6 in transgenic mice. Uncoupling of airway inflammation and bronchial hyperreactivity

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Oncostatin M stimulates collagen and glycosaminoglycan production by cultured normal dermal fibroblasts: insensitivity of sclerodermal and keloidal fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Transforming growth factor-beta1 induces interleukin-6 expression via activating protein-1 consisting of JunD homodimers in primary human lung fibroblasts.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

A new protein containing an SH2 domain that inhibits JAK kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Gp130-mediated signal transduction in embryonic stem cells involves activation of Jak and Ras/mitogen-activated protein kinase pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Defective gp130-mediated signal transducer and activator of transcription (STAT) signaling results in degenerative joint disease, gastrointestinal ulceration, and failure of uterine implantation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Evidence of fibroblast heterogeneity and the role of fibroblast subpopulations in fibrosis

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Two signals are necessary for cell proliferation induced by a cytokine receptor gp130: involvement of STAT3 in anti-apoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

COX-2 expression and cell cycle progression in human fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Enhanced production of interleukin-6 (IL-6), oncostatin M and soluble IL-6 receptor by cultured peripheral blood mononuclear cells from patients with systemic sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Gab-family adapter molecules in signal transduction of cytokine and growth factor receptors, and T and B cell antigen receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Signaling mechanisms through gp130: a model of the cytokine system.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Continuous activation of gp130, a signal-transducing receptor component for interleukin 6-related cytokines, causes myocardial hypertrophy in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Epithelial-mesenchymal interactions in the pathogenesis of asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Oncostatin M stimulates the growth of dermal fibroblasts via a mitogen-activated protein kinase-dependent pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Oncostatin M Stimulates Transcription of the Human α2(I) Collagen Gene via the Sp1/Sp3-binding Site

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Close proximity of the genes for leukemia inhibitory factor and oncostatin M

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Endogenous IL-1alpha from systemic sclerosis fibroblasts induces IL-6 and PDGF-A.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Protein tyrosine phosphatase 2 (SHP-2) moderates signaling by gp130 but is not required for the induction of acute-phase plasma protein genes in hepatic cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Idiopathic pulmonary fibrosis: relationship between histopathologic features and mortality

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Leukemia inhibitory factor (LIF) and LIF receptor in human lung. Distribution and regulation of LIF release

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Oncostatin M synergises with house dust mite proteases to induce the production of PGE(2) from cultured lung epithelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Differences in the fibrogenic response after transfer of active transforming growth factor-beta1 gene to lungs of "fibrosis-prone" and "fibrosis-resistant" mouse strains

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Oncostatin M regulates eotaxin expression in fibroblasts and eosinophilic inflammation in C57BL/6 mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

1 reference

7 January 2021

Essential function of LIF receptor in motor neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Inhibition of Stat1-mediated gene activation by PIAS1

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

The pathogenesis of pulmonary fibrosis: is there a fibrosis gene?

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Adult familial cryptogenic fibrosing alveolitis in the United Kingdom

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

NHLBI Workshop Summary. Pharmacological therapy for idiopathic pulmonary fibrosis. Past, present, and future

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Regulation of fibroblast procollagen production. Transforming growth factor-beta 1 induces prostaglandin E2 but not procollagen synthesis via a pertussis toxin-sensitive G-protein

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Inverse effects of interleukin-6 on apoptosis of fibroblasts from pulmonary fibrosis and normal lungs.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Fibroblasts isolated from normal lungs and those with idiopathic pulmonary fibrosis differ in interleukin-6/gp130-mediated cell signaling and proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Mechanisms of tissue repair: from wound healing to fibrosis

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Structure and function of a new STAT-induced STAT inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Dissection of signaling cascades through gp130 in vivo: reciprocal roles for STAT3- and SHP2-mediated signals in immune responses.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

GM-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8, IL-10, ICAM-1 and VCAM-1 gene expression and cytokine production in human duodenal fibroblasts stimulated with lipopolysaccharide, IL-1 alpha and TNF-alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Analysis of tumor necrosis factor-alpha, lymphotoxin-alpha, tumor necrosis factor receptor II, and interleukin-6 polymorphisms in patients with idiopathic pulmonary fibrosis

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Water transport revisited

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Regulated overexpression of interleukin 11 in the lung. Use to dissociate development-dependent and -independent phenotypes

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Intracellular interleukin 6 mediates platelet-derived growth factor-induced proliferation of nontransformed cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Oncostatin M stimulates proliferation, induces collagen production and inhibits apoptosis of human lung fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Box 3-independent signaling mechanisms are involved in leukemia inhibitory factor receptor alpha- and gp130-mediated stimulation of mitogen-activated protein kinase. Evidence for participation of multiple signaling pathways which converge at Ras

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Heterogeneity of myofibroblast phenotypic features: an example of fibroblastic cell plasticity

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Mechanisms of myofibroblast activity and phenotypic modulation.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Effect of IL-6 on alveolar fibroblast proliferation in interstitial lung diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

TNF and IL-6 mediate MIP-1alpha expression in bleomycin-induced lung injury

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Interstitial collagens I, III, and VI sequester and modulate the multifunctional cytokine oncostatin M.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Negative regulation of the JAK/STAT pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

The protein tyrosine phosphatase SHP-2 negatively regulates ciliary neurotrophic factor induction of gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

The signal transducer gp130 is shared by interleukin-6 family of haematopoietic and neurotrophic cytokines

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Targeted expression of IL-11 in the murine airway causes lymphocytic inflammation, bronchial remodeling, and airways obstruction

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Allelic imbalance demonstrated by microsatellite analysis of lung samples from patients with familial pulmonary fibrosis

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Radiation-induced pulmonary endothelial dysfunction and hydroxyproline accumulation in four strains of mice

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Acute-phase response factor, a nuclear factor binding to acute-phase response elements, is rapidly activated by interleukin-6 at the posttranslational level

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

A histologically distinctive interstitial pneumonia induced by overexpression of the interleukin 6, transforming growth factor beta 1, or platelet-derived growth factor B gene

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900095-0

7 January 2021

10.1016/S0163-7258(03)00095-0

Identifiers

DOI

1 reference

3 November 2017

1 reference