ERCC excision repair 2, TFIIH core complex helicase subunit (Q426168)

RAD3/XPD family

1 reference

ATP-dependent helicase, C-terminal domain, protein family

1 reference

Helical and beta-bridge domain, protein family

1 reference

DEAD2, protein family

1 reference

Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type, protein family

1 reference

Helicase-like, DEXD box c2 type, protein family

1 reference

DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site, protein family

1 reference

4 iron, 4 sulfur cluster binding

1 reference

13 November 2019

1 reference

13 November 2019

2 references

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes

protein kinase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

ATP-dependent activity, acting on DNA

2 references

8 April 2019

A 3' --> 5' XPB helicase defect in repair/transcription factor TFIIH of xeroderma pigmentosum group B affects both DNA repair and transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

8 April 2019

Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

protein N-terminus binding

1 reference

8 April 2019

Interactions involving the human RNA polymerase II transcription/nucleotide excision repair complex TFIIH, the nucleotide excision repair protein XPG, and Cockayne syndrome group B (CSB) protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

iron-sulfur cluster binding

IPI

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18074&geneProductId=UniProtKB:P18074

DNA helicase activity

1 reference

16 July 2018

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

protein C-terminus binding

1 reference

8 April 2019

Distinct regions of MAT1 regulate cdk7 kinase and TFIIH transcription activities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

10 references

8 April 2019

IOP1 protein is an external component of the human cytosolic iron-sulfur cluster assembly (CIA) machinery and functions in the MMS19 protein-dependent CIA pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

8 April 2019

Interactions involving the human RNA polymerase II transcription/nucleotide excision repair complex TFIIH, the nucleotide excision repair protein XPG, and Cockayne syndrome group B (CSB) protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

8 April 2019

A yeast four-hybrid system identifies Cdk-activating kinase as a regulator of the XPD helicase, a subunit of transcription factor IIH

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

8 April 2019

Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

8 April 2019

MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in chromosome segregation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

8 April 2019

p53 modulation of TFIIH-associated nucleotide excision repair activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

8 April 2019

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

8 April 2019

Dynamic interaction of TTDA with TFIIH is stabilized by nucleotide excision repair in living cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

8 April 2019

The CIA Targeting Complex Is Highly Regulated and Provides Two Distinct Binding Sites for Client Iron-Sulfur Proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

8 April 2019

Near-atomic resolution visualization of human transcription promoter opening

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

RNA polymerase II CTD heptapeptide repeat kinase activity

1 reference

16 July 2018

Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18074&geneProductId=UniProtKB:P18074

5'-3' DNA helicase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

2 references

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

RNA polymerase II CTD heptapeptide repeat kinase activity

protein-macromolecule adaptor activity

1 reference

8 April 2019

A yeast four-hybrid system identifies Cdk-activating kinase as a regulator of the XPD helicase, a subunit of transcription factor IIH

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

5'-3' DNA helicase activity

IPI

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

8 April 2019

IOP1 protein is an external component of the human cytosolic iron-sulfur cluster assembly (CIA) machinery and functions in the MMS19 protein-dependent CIA pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

8 April 2019

MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in chromosome segregation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

cyclin-dependent protein kinase activating kinase holoenzyme complex

transcription factor TFIIH holo complex

transcription factor TFIIH core complex

2 references

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

4 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18074&geneProductId=UniProtKB:P18074

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18074&geneProductId=UniProtKB:P18074

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18074&geneProductId=UniProtKB:P18074

16 July 2018

MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in chromosome segregation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18074&geneProductId=UniProtKB:P18074

1 reference

8 April 2019

MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in chromosome segregation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

transcription factor TFIID complex

1 reference

8 April 2019

Near-atomic resolution visualization of human transcription promoter opening

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

8 April 2019

IOP1 protein is an external component of the human cytosolic iron-sulfur cluster assembly (CIA) machinery and functions in the MMS19 protein-dependent CIA pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

8 April 2019

MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in chromosome segregation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

termination of RNA polymerase I transcription

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

regulation of mitotic cell cycle phase transition

1 reference

8 April 2019

DNA nucleotide excision repair-dependent signaling to checkpoint activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

regulation of transcription, DNA-templated

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18074&geneProductId=UniProtKB:P18074

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

hair follicle maturation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

multicellular organism growth

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

transcription initiation from RNA polymerase I promoter

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

transcription elongation from RNA polymerase II promoter

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

extracellular matrix organization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

in utero embryonic development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

7-methylguanosine mRNA capping

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

transcription by RNA polymerase II

3 references

16 July 2018

A 3' --> 5' XPB helicase defect in repair/transcription factor TFIIH of xeroderma pigmentosum group B affects both DNA repair and transcription

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18074&geneProductId=UniProtKB:P18074

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18074&geneProductId=UniProtKB:P18074

16 July 2018

Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18074&geneProductId=UniProtKB:P18074

post-embryonic development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

transcription, DNA-templated

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18074&geneProductId=UniProtKB:P18074

cellular response to DNA damage stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

positive regulation of transcription, DNA-templated

1 reference

16 July 2018

Human cyclin-dependent kinase-activating kinase exists in three distinct complexes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18074&geneProductId=UniProtKB:P18074

global genome nucleotide-excision repair

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

hematopoietic stem cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

spinal cord development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

positive regulation of DNA binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

central nervous system myelin formation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

transcription initiation from RNA polymerase II promoter

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

cell population proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

nucleobase-containing compound metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18074&geneProductId=UniProtKB:P18074

positive regulation of transcription by RNA polymerase II

1 reference

8 April 2019

Isolation and characterization of two human transcription factor IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIH

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

erythrocyte maturation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

1 reference

8 April 2019

The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

nucleotide-excision repair

IMP

4 references

8 April 2019

ERCC2: cDNA cloning and molecular characterization of a human nucleotide excision repair gene with high homology to yeast RAD3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

8 April 2019

Molecular cloning and biological characterization of a human gene, ERCC2, that corrects the nucleotide excision repair defect in CHO UV5 cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

nucleotide-excision repair, preincision complex stabilization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

protein phosphorylation

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

nucleotide-excision repair, preincision complex assembly

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

nucleotide-excision repair, DNA incision, 5'-to lesion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

embryonic organ development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

1 reference

16 July 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18074&geneProductId=UniProtKB:P18074

regulation of mitotic recombination

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

nucleotide-excision repair, DNA duplex unwinding

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18074&geneProductId=UniProtKB:P18074

transcription by RNA polymerase II

4 references

8 April 2019

A 3' --> 5' XPB helicase defect in repair/transcription factor TFIIH of xeroderma pigmentosum group B affects both DNA repair and transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

8 April 2019

Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

response to oxidative stress

3 references

8 April 2019

Genetic susceptibility of newborn daughters to oxidative stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

nucleotide-excision repair, DNA incision

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

8 April 2019

Isolation and characterization of two human transcription factor IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIH

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

positive regulation of mitotic recombination

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

nucleotide-excision repair, DNA incision, 3'-to lesion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

transcription elongation from RNA polymerase I promoter

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074

http://purl.uniprot.org/uniprot/P18074

Gene Atlas image

PBB GE ERCC2 213468 at fs.png
732 × 530; 11 KB

0 references

exact match

1 reference

Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type

Identifiers.org

has part(s)

1 reference

ATP-dependent helicase, C-terminal

1 reference

DEAD2

1 reference

DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site

1 reference

Helical and beta-bridge domain

1 reference

Helicase-like, DEXD box c2 type

1 reference

D08.811.277.040.025.159.500

Identifiers

MeSH descriptor ID

D051759

subject named as

Xeroderma Pigmentosum Group D Protein

0 references

MeSH tree code

0 references

D08.811.399.340.500

0 references

D12.776.260.775.875.875.500

0 references

D12.776.930.930.875.875.500

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

0 references

Microsoft Academic ID

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

inferred by common MeSH mappings on source and on Wikidata

1 reference