Two arginine rich domains in the p14ARF tumour suppressor mediate nucleolar localization. (Q42628813)

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7 November 2019

title

Two arginine rich domains in the p14ARF tumour suppressor mediate nucleolar localization (English)

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7 November 2019

1

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7 November 2019

Graham J Mann

series ordinal

3

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7 November 2019

Richard F. Kefford

series ordinal

4

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7 November 2019

author name string

A P Darmanian

series ordinal

2

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7 November 2019

language of work or name

English

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publication date

1 June 2000

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7 November 2019

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7 November 2019

volume

19

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7 November 2019

issue

26

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7 November 2019

page(s)

2978-2985

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p14ARF links the tumour suppressors RB and p53.

7 November 2019

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E1A signaling to p53 involves the p19(ARF) tumor suppressor

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Prevalence of germ-line mutations in p16, p19ARF, and CDK4 in familial melanoma: analysis of a clinic-based population

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Mdm2 association with p53 targets its ubiquitination

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Germline Mutations of the CDKN2 Gene in UK Melanoma Families

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Interactions between HIV Rev and nuclear import and export factors: the Rev nuclear localisation signal mediates specific binding to human importin-beta

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Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

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Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

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Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

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An inhibitor of nuclear export activates the p53 response and induces the localization of HDM2 and p53 to U1A-positive nuclear bodies associated with the PODs

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The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

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Temperature-sensitive mutants of p16CDKN2 associated with familial melanoma

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The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

21 January 2018

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Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16INK4a but not by the alternative reading frame protein p19ARF.

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Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

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Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.

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The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

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21 January 2018

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Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53

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21 January 2018

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7 January 2021

p16/CDKN2 andCDK4 gene mutations in sporadic melanoma development and progression

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1203629

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10871849%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

7 November 2019

1044440060

0 references

1 reference