The INK4A/ARF locus and its two gene products (Q33540080)

27 July 2017

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title

The INK4A/ARF locus and its two gene products (English)

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27 July 2017

1

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27 July 2017

DePinho RA

2

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PubMed ID

10072356

27 July 2017

language of work or name

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1 February 1999

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Current Opinion in Genetics & Development

27 July 2017

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27 July 2017

9

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27 July 2017

1

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27 July 2017

22-30

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https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

27 July 2017

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7 January 2021

p53, the cellular gatekeeper for growth and division

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

A cell cycle regulator potentially involved in genesis of many tumor types

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https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

Review of alterations of the cyclin-dependent kinase inhibitor INK4 family genes p15, p16, p18 and p19 in human leukemia-lymphoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

Germline p16 mutations in familial melanoma

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

Analysis of the p16 gene (CDKN2) as a candidate for the chromosome 9p melanoma susceptibility locus

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

Increased Risk of Pancreatic Cancer in Melanoma-Prone Kindreds withp16INK4Mutations

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

Prevalence of germ-line mutations in p16, p19ARF, and CDK4 in familial melanoma: analysis of a clinic-based population

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

Analysis of the CDKN2A, CDKN2B and CDK4 genes in 48 Australian melanoma kindreds

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

Inhibition of ras-induced proliferation and cellular transformation by p16INK4.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition

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https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

The regulation of E2F by pRB-family proteins

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https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a

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https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

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https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

Senescence of human fibroblasts induced by oncogenic Raf.

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https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

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https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

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https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

Regulation of p53 stability by Mdm2

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https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

Mdm2 promotes the rapid degradation of p53

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https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

Tumor surveillance via the ARF-p53 pathway.

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https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16INK4a but not by the alternative reading frame protein p19ARF.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

E1A signaling to p53 involves the p19(ARF) tumor suppressor

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https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

p19ARF links the tumour suppressor p53 to Ras

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

p19(Arf) induces p53-dependent apoptosis during abelson virus-mediated pre-B cell transformation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

p14ARF links the tumour suppressors RB and p53.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

Induction of apoptosis in fibroblasts by c-myc protein

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https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

p53 and E2F-1 cooperate to mediate apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

Role of the INK4a locus in tumor suppression and cell mortality.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

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https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

Tumor spectrum analysis in p53-mutant mice

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https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

Mutations and polymorphisms in the p53, p21 and p16 genes in oral carcinomas of Indian betel quid chewers

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

Among genes involved in the RB dependent cell cycle regulatory cascade, the p16 tumor suppressor gene is frequently lost in the Ewing family of tumors.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

Alterations of multiple tumor suppressor genes (p53 (17p13), p16INK4 (9p21), and DBM (13q14)) in B-cell chronic lymphocytic leukemia.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

Alterations of the p16 gene in head and neck cancer: frequency and association with p53, PRAD-1 and HPV

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

Analysis of the p16INK4 and TP53 tumor suppressor genes in bone sarcoma pediatric patients

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

Analysis of p53, p16MTS, p21WAF1 and H-ras in archived bladder tumours from workers exposed to aromatic amines

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

Mutations and altered expression of p16INK4 in human cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

Homozygotes for CDKN2 (p16) germline mutation in Dutch familial melanoma kindreds

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

Brief report: a familial syndrome of pancreatic cancer and melanoma with a mutation in the CDKN2 tumor-suppressor gene

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

CDKN2A mutations in multiple primary melanomas

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

Molecular genetics of familial cutaneous melanoma

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

p16INK4A participates in a G1 arrest checkpoint in response to DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

A functionally inactive p53 protein in teratocarcinoma cells is activated by either DNA damage or cellular differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

Binding and modulation of p53 by p300/CBP coactivators

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

Synergistic activation of transcription by CBP and p53

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https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

Recruitment of p300/CBP in p53-dependent signal pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

p300/MDM2 complexes participate in MDM2-mediated p53 degradation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5

7 January 2021

10.1016/S0959-437X(99)80004-5

Identifiers

DOI

1 reference

27 July 2017

1 reference

PubMed ID

10072356