Three metal ions participate in the reaction catalyzed by T5 flap endonuclease. (Q42632884)

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12 January 2020

title

Three metal ions participate in the reaction catalyzed by T5 flap endonuclease (English)

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12 January 2020

4

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John A. Tainer

5

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12 January 2020

Nicholas H Williams

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author name string

Karl Syson

1

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12 January 2020

Christopher Tomlinson

2

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Brian R Chapados

3

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12 January 2020

Jane A Grasby

7

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language of work or name

English

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publication date

11 August 2008

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Journal of Biological Chemistry

12 January 2020

published in

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volume

283

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issue

42

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12 January 2020

page(s)

28741-28746

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DNA apurinic-apyrimidinic site binding and excision by endonuclease IV

12 January 2020

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Crystal structure of bacteriophage T4 5' nuclease in complex with a branched DNA reveals how flap endonuclease-1 family nucleases bind their substrates

27 May 2018

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Comparison of the catalytic parameters and reaction specificities of a phage and an archaeal flap endonuclease

27 May 2018

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Alternative roles for metal ions in enzyme catalysis and the implications for ribozyme chemistry

27 May 2018

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27 May 2018

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Making and breaking nucleic acids: two-Mg2+-ion catalysis and substrate specificity

27 May 2018

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27 May 2018

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Crystal structures of RNase H bound to an RNA/DNA hybrid: substrate specificity and metal-dependent catalysis

27 May 2018

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Type II restriction endonucleases: structure and mechanism

27 May 2018

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Maturation of bacteriophage T4 lagging strand fragments depends on interaction of T4 RNase H with T4 32 protein rather than the T4 gene 45 clamp

27 May 2018

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Structural basis for recruitment of human flap endonuclease 1 to PCNA

27 May 2018

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Roles of divalent metal ions in flap endonuclease-substrate interactions.

27 May 2018

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Structural basis for FEN-1 substrate specificity and PCNA-mediated activation in DNA replication and repair

27 May 2018

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Dynamic evidence for metal ion catalysis in the reaction mediated by a flap endonuclease.

27 May 2018

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Distinct roles of two Mg2+ binding sites in regulation of murine flap endonuclease-1 activities

27 May 2018

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Molecular structure and novel DNA binding sites located in loops of flap endonuclease-1 from Pyrococcus horikoshii

27 May 2018

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A conserved tyrosine residue aids ternary complex formation, but not catalysis, in phage T5 flap endonuclease

27 May 2018

1 reference

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Interactions of mutant and wild-type flap endonucleases with oligonucleotide substrates suggest an alternative model of DNA binding

27 May 2018

1 reference

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Three metal ions at the active site of the Tetrahymena group I ribozyme

27 May 2018

1 reference

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Structure of the DNA repair enzyme endonuclease IV and its DNA complex: double-nucleotide flipping at abasic sites and three-metal-ion catalysis

27 May 2018

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Structure of the DNA repair and replication endonuclease and exonuclease FEN-1: coupling DNA and PCNA binding to FEN-1 activity

27 May 2018

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The crystal structure of flap endonuclease-1 from Methanococcus jannaschii

27 May 2018

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Functional analysis of point mutations in human flap endonuclease-1 active site

27 May 2018

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Effects of divalent metal ions on individual steps of the Tetrahymena ribozyme reaction

27 May 2018

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Structure of bacteriophage T4 RNase H, a 5' to 3' RNA-DNA and DNA-DNA exonuclease with sequence similarity to the RAD2 family of eukaryotic proteins

27 May 2018

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A helical arch allowing single-stranded DNA to thread through T5 5'-exonuclease

27 May 2018

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Crystal structure of Thermus aquaticus DNA polymerase

27 May 2018

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High-resolution (1.5 A) crystal structure of phospholipase C from Bacillus cereus

27 May 2018

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Structure of ribonuclease H phased at 2 A resolution by MAD analysis of the selenomethionyl protein

27 May 2018

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Reaction mechanism of alkaline phosphatase based on crystal structures. Two-metal ion catalysis

27 May 2018

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Structural basis for the 3'-5' exonuclease activity of Escherichia coli DNA polymerase I: a two metal ion mechanism

27 May 2018

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Crystal structure of Penicillium citrinum P1 nuclease at 2.8 A resolution

27 May 2018

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Properties of overexpressed phage T5 D15 exonuclease. Similarities with Escherichia coli DNA polymerase I 5'-3' exonuclease.

27 May 2018

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Activation of orotidine 5'-monophosphate decarboxylase by phosphite dianion: the whole substrate is the sum of two parts

27 May 2018

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DNA cleavage by EcoRV endonuclease: two metal ions in three metal ion binding sites.

16 August 2018

1 reference

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Crystal structure of phospholipase C from Bacillus cereus complexed with a substrate analog.

16 August 2018

1 reference

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Divalent metal ions at the active sites of the EcoRV and EcoRI restriction endonucleases.

16 August 2018

1 reference

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Role of divalent cations in the 3',5'-exonuclease reaction of DNA polymerase I

16 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18697748

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identification of residues of T4 RNase H required for catalysis and DNA binding

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18697748

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Variation in the steady state kinetic parameters of wild type and mutant T5 5'-3'-exonuclease with pH. Protonation of Lys-83 is critical for DNA binding

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18697748

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M801264200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18697748%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18697748%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

PubMed publication ID

18697748

1 reference