BAG-1 stabilizes mutant F508del-CFTR in a ubiquitin-like-domain-dependent manner (Q42677991)

4 November 2017

title

BAG-1 stabilizes mutant F508del-CFTR in a ubiquitin-like-domain-dependent manner (English)

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4 November 2017

author

Margarida Duarte Amaral

6

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Carlos M Farinha

2

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Filipa Mendes

object named as

Filipa Mendes

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author name string

Verónica Felício

3

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4 November 2017

Paulo C Alves

4

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Isabel Vieira

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publication date

5 October 2012

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Cellular Physiology and Biochemistry

4 November 2017

published in

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volume

30

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issue

5

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page(s)

1120-1133

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The common variant of cystic fibrosis transmembrane conductance regulator is recognized by hsp70 and degraded in a pre-Golgi nonlysosomal compartment

4 November 2017

cites work

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The human DnaJ homologue (Hdj)-1/heat-shock protein (Hsp) 40 co-chaperone is required for the in vivo stabilization of the cystic fibrosis transmembrane conductance regulator by Hsp70

21 January 2018

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The Hdj-2/Hsc70 chaperone pair facilitates early steps in CFTR biogenesis

21 January 2018

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Perturbation of Hsp90 interaction with nascent CFTR prevents its maturation and accelerates its degradation by the proteasome

21 January 2018

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A foldable CFTR{Delta}F508 biogenic intermediate accumulates upon inhibition of the Hsc70-CHIP E3 ubiquitin ligase

21 January 2018

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BAG-2 acts as an inhibitor of the chaperone-associated ubiquitin ligase CHIP.

21 January 2018

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Cysteine string protein promotes proteasomal degradation of the cystic fibrosis transmembrane conductance regulator (CFTR) by increasing its interaction with the C terminus of Hsp70-interacting protein and promoting CFTR ubiquitylation.

21 January 2018

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Defective intracellular transport and processing of CFTR is the molecular basis of most cystic fibrosis

21 January 2018

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Multiple proteolytic systems, including the proteasome, contribute to CFTR processing

21 January 2018

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Degradation of CFTR by the ubiquitin-proteasome pathway

21 January 2018

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Revertant mutants G550E and 4RK rescue cystic fibrosis mutants in the first nucleotide-binding domain of CFTR by different mechanisms

21 January 2018

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Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity

21 January 2018

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The BAG proteins: a ubiquitous family of chaperone regulators

21 January 2018

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Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1

21 January 2018

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GrpE-like regulation of the hsc70 chaperone by the anti-apoptotic protein BAG-1

21 January 2018

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BAG-1 modulates the chaperone activity of Hsp70/Hsc70.

21 January 2018

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Role of Hsc70 binding cycle in CFTR folding and endoplasmic reticulum-associated degradation

21 January 2018

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The mechanism underlying cystic fibrosis transmembrane conductance regulator transport from the endoplasmic reticulum to the proteasome includes Sec61beta and a cytosolic, deglycosylated intermediary

21 January 2018

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High level expression of differentially localized BAG-1 isoforms in some oestrogen receptor-positive human breast cancers.

21 January 2018

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Immunocytochemical localization of the cystic fibrosis gene product CFTR

21 January 2018

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Sequential quality-control checkpoints triage misfolded cystic fibrosis transmembrane conductance regulator

21 January 2018

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Hsp70 molecular chaperone facilitates endoplasmic reticulum-associated protein degradation of cystic fibrosis transmembrane conductance regulator in yeast

21 January 2018

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Posttranscriptional regulation of hsp70 expression in human cells: effects of heat shock, inhibition of protein synthesis, and adenovirus infection on translation and mRNA stability

21 January 2018

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Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators

21 January 2018

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Hyperthermia and the heat-shock proteins of HeLa cells

21 January 2018

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Correlation between synthesis of heat shock proteins and development of thermotolerance in Chinese hamster fibroblasts

21 January 2018

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Structure of a Bag/Hsc70 complex: convergent functional evolution of Hsp70 nucleotide exchange factors

21 January 2018

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Modulation of in vivo HSP70 chaperone activity by Hip and Bag-1.

21 January 2018

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Cooperation of a ubiquitin domain protein and an E3 ubiquitin ligase during chaperone/proteasome coupling

21 January 2018

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p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1.

21 January 2018

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BAG-1 associates with Hsc70.Tau complex and regulates the proteasomal degradation of Tau protein.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1159/000343303

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4 November 2017

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