BAG-1 associates with Hsc70.Tau complex and regulates the proteasomal degradation of Tau protein. (Q40063710)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17954934%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

title

BAG-1 associates with Hsc70.Tau complex and regulates the proteasomal degradation of Tau protein (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17954934%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17954934%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

author name string

Evan Elliott

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17954934%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

Irith Ginzburg

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17954934%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

language of work or name

English

0 references

publication date

22 October 2007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17954934%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

9 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17954934%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

volume

282

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17954934%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

issue

51

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17954934%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

page(s)

37276-37284

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17954934%20AND%20SRC:MED&resulttype=core&format=json

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology

9 January 2020

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706379200

The interrelationship between selective tau phosphorylation and microtubule association.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706379200

Clogging of axons by tau, inhibition of axonal traffic and starvation of synapses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706379200

Missorting of tau in neurons causes degeneration of synapses that can be rescued by the kinase MARK2/Par-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706379200

The "jaws" of the tau-microtubule interaction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706379200

Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706379200

The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706379200

Chaperones increase association of tau protein with microtubules

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706379200

CHIP-Hsc70 Complex Ubiquitinates Phosphorylated Tau and Enhances Cell Survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706379200

U-box protein carboxyl terminus of Hsc70-interacting protein (CHIP) mediates poly-ubiquitylation preferentially on four-repeat Tau and is involved in neurodegeneration of tauopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706379200

CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706379200

Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho- and caspase-3-cleaved tau species.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706379200

HSP induction mediates selective clearance of tau phosphorylated at proline-directed Ser/Thr sites but not KXGS (MARK) sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706379200

Current strategies for the treatment of Alzheimer's disease and other tauopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706379200

Bag1 is essential for differentiation and survival of hematopoietic and neuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706379200

Distinct isoforms of the cofactor BAG-1 differentially affect Hsc70 chaperone function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706379200

Interaction of BAG1 and Hsp70 mediates neuroprotectivity and increases chaperone activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706379200

A mechanism of ubiquitin-independent proteasomal degradation of the tumor suppressors p53 and p73

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706379200

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706379200

Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706379200

Proteasomal degradation of tau protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706379200

The ubiquitin-related BAG-1 provides a link between the molecular chaperones Hsc70/Hsp70 and the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706379200

21 January 2018

Identifiers

DOI

10.1074/JBC.M706379200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17954934%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

1 reference