Computational methods for identifying a layered allosteric regulatory mechanism for ALS-causing mutations of Cu-Zn superoxide dismutase 1 (Q42694170)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21104697%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

title

Computational methods for identifying a layered allosteric regulatory mechanism for ALS-causing mutations of Cu-Zn superoxide dismutase 1 (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21104697%20AND%20SRC:MED&resulttype=core&format=json

amyotrophic lateral sclerosis

17 January 2020

main subject

1 reference

1

1 reference

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17 January 2020

Heather A Carlson

series ordinal

2

1 reference

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17 January 2020

Eva Feldman

series ordinal

3

1 reference

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17 January 2020

3

Eva L Feldman

1 reference

5 November 2017

language of work or name

English

0 references

publication date

1 February 2011

1 reference

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17 January 2020

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17 January 2020

volume

79

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17 January 2020

issue

2

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17 January 2020

page(s)

417-427

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Computational methods for predicting sites of functionally important dynamics.

17 January 2020

cites work

1 reference

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Allosteric communication occurs via networks of tertiary and quaternary motions in proteins

27 May 2018

1 reference

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Iterative cluster-NMA: A tool for generating conformational transitions in proteins

27 May 2018

1 reference

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Insulin-like growth factor-I for the treatment of amyotrophic lateral sclerosis

27 May 2018

1 reference

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A poke in the eye: inhibiting HIV-1 protease through its flap-recognition pocket

27 May 2018

1 reference

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Small molecule inhibitors of the MDM2-p53 interaction discovered by ensemble-based receptor models.

27 May 2018

1 reference

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Whole-genome analysis of sporadic amyotrophic lateral sclerosis

27 May 2018

1 reference

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How do ALS-associated mutations in superoxide dismutase 1 promote aggregation of the protein?

27 May 2018

1 reference

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Dynamically driven protein allostery.

27 May 2018

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Markov propagation of allosteric effects in biomolecular systems: application to GroEL-GroES.

27 May 2018

1 reference

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Low-frequency normal modes that describe allosteric transitions in biological nanomachines are robust to sequence variations

27 May 2018

1 reference

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Can conformational change be described by only a few normal modes?

27 May 2018

1 reference

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Destabilization of apoprotein is insufficient to explain Cu,Zn-superoxide dismutase-linked ALS pathogenesis.

27 May 2018

1 reference

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Efficient determination of low-frequency normal modes of large protein structures by cluster-NMA.

27 May 2018

1 reference

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Copper-zinc superoxide dismutase and amyotrophic lateral sclerosis

27 May 2018

1 reference

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Reaction coordinates and rates from transition paths

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058251

Small-molecule-mediated stabilization of familial amyotrophic lateral sclerosis-linked superoxide dismutase mutants against unfolding and aggregation

27 May 2018

1 reference

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Is allostery an intrinsic property of all dynamic proteins?

27 May 2018

1 reference

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Unraveling the mechanisms involved in motor neuron degeneration in ALS

27 May 2018

1 reference

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Dimer destabilization in superoxide dismutase may result in disease-causing properties: structures of motor neuron disease mutants.

27 May 2018

1 reference

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The role of dynamics in allosteric regulation

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058251

Implications of protein flexibility for drug discovery

27 May 2018

1 reference

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Amyloid-like filaments and water-filled nanotubes formed by SOD1 mutant proteins linked to familial ALS

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058251

The structure of holo and metal-deficient wild-type human Cu, Zn superoxide dismutase and its relevance to familial amyotrophic lateral sclerosis

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058251

Multiple diverse ligands binding at a single protein site: a matter of pre-existing populations

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058251

Anisotropy of fluctuation dynamics of proteins with an elastic network model

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058251

Structural stability of binding sites: consequences for binding affinity and allosteric effects.

27 May 2018

1 reference

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Accommodating protein flexibility in computational drug design

27 May 2018

1 reference

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27 May 2018

The Protein Data Bank

1 reference

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Subunit asymmetry in the three-dimensional structure of a human CuZnSOD mutant found in familial amyotrophic lateral sclerosis

27 May 2018

1 reference

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Molecular docking to ensembles of protein structures

27 May 2018

1 reference

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Computer simulation of protein folding

27 May 2018

1 reference

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Local motions in a benchmark of allosteric proteins.

27 May 2018

1 reference

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Interpreting correlated motions using normal mode analysis.

16 August 2018

1 reference

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Theoretical studies of transition states by the multioverlap molecular dynamics methods.

16 August 2018

1 reference

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Normal mode analysis of proteins: a comparison of rigid cluster modes with C(alpha) coarse graining.

16 August 2018

1 reference

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Copper-binding-site-null SOD1 causes ALS in transgenic mice: aggregates of non-native SOD1 delineate a common feature

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058251

Variation in the biochemical/biophysical properties of mutant superoxide dismutase 1 enzymes and the rate of disease progression in familial amyotrophic lateral sclerosis kindreds.

16 August 2018

1 reference

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Large Amplitude Elastic Motions in Proteins from a Single-Parameter, Atomic Analysis

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058251

A computational investigation of allostery in the catabolite activator protein

1 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21104697

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Incorporating protein flexibility in structure-based drug discovery: using HIV-1 protease as a test case

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21104697

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1002/PROT.22892

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21104697%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21104697%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

PubMed publication ID

21104697

1 reference