Phase separation of signaling molecules promotes T cell receptor signal transduction (Q42742423)

6 November 2017

Phase separation of signaling molecules promotes T cell receptor signal transduction (English)

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6 November 2017

10

Ronald D Vale

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6 November 2017

Xiaolei Su

1

1 reference

6 November 2017

Jonathon A Ditlev

2

1 reference

6 November 2017

Enfu Hui

3

1 reference

6 November 2017

Wenmin Xing

4

1 reference

6 November 2017

Sudeep Banjade

5

1 reference

6 November 2017

Julia Okrut

6

1 reference

6 November 2017

David S King

7

1 reference

6 November 2017

Jack Taunton

8

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6 November 2017

Michael K Rosen

9

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6 November 2017

language of work or name

English

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publication date

7 April 2016

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6 November 2017

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6 November 2017

352

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6 November 2017

595-599

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6 November 2017

6285

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GRB2 Nucleates T Cell Receptor-Mediated LAT Clusters That Control PLC-γ1 Activation and Cytokine Production.

6 November 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4892427

Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4892427

Phase transitions of multivalent proteins can promote clustering of membrane receptors

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4892427

Liquid-liquid phase separation in biology

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4892427

Signalosome assembly by domains undergoing dynamic head-to-tail polymerization

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4892427

Insights into the initiation of TCR signaling

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4892427

In vitro membrane reconstitution of the T-cell receptor proximal signaling network

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4892427

Higher-order assemblies in a new paradigm of signal transduction

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4892427

The SH2 domain interaction landscape

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4892427

Stoichiometry of Nck-dependent actin polymerization in living cells

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4892427

Receptor signaling clusters in the immune synapse

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4892427

Phase transitions in the assembly of multivalent signalling proteins

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4892427

Spatiotemporal patterning during T cell activation is highly diverse

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4892427

Aggregation of membrane proteins by cytosolic cross-linkers: theory and simulation of the LAT-Grb2-SOS1 system

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4892427

Oligomerization of signaling complexes by the multipoint binding of GRB2 to both LAT and SOS1

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4892427

T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4892427

Single-molecule microscopy reveals plasma membrane microdomains created by protein-protein networks that exclude or trap signaling molecules in T cells

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4892427

Jurkat T cells and development of the T-cell receptor signalling paradigm

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4892427

Minimal requirement of tyrosine residues of linker for activation of T cells in TCR signaling and thymocyte development.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4892427

T cell receptor ligation induces the formation of dynamically regulated signaling assemblies

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4892427

Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathway

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4892427

Association of Nck with tyrosine-phosphorylated SLP-76 in activated T lymphocytes

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4892427

LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4892427

The cytoplasmic domain of the T cell receptor zeta chain is sufficient to couple to receptor-associated signal transduction pathways

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4892427

ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4892427

Dynamic actin polymerization drives T cell receptor-induced spreading: a role for the signal transduction adaptor LAT.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4892427

Analyzing the homeostasis of signaling proteins by a combination of Western blot and fluorescence correlation spectroscopy

16 August 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD9964

TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD9964

Functional nanoscale organization of signaling molecules downstream of the T cell antigen receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD9964

Pre-existing clusters of the adaptor Lat do not participate in early T cell signaling events

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD9964

The kinetic-segregation model: TCR triggering and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD9964

21 January 2018

Identifiers

DOI

10.1126/SCIENCE.AAD9964

1 reference

6 November 2017

1 reference

6 November 2017

1 reference