Irinotecan and DNA-PKcs inhibitors synergize in killing of colon cancer cells (Q42759480)

6 November 2017

Irinotecan and DNA-PKcs inhibitors synergize in killing of colon cancer cells (English)

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6 November 2017

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David Davidson

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6 November 2017

Yannick Coulombe

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6 November 2017

Veronica L Martinez-Marignac

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6 November 2017

Lilian Amrein

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6 November 2017

Jeremy Grenier

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6 November 2017

Keira Hodkinson

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6 November 2017

Jean-Yves Masson

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6 November 2017

Raquel Aloyz

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6 November 2017

Lawrence Panasci

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6 November 2017

11 January 2011

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Investigational New Drugs

6 November 2017

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6 November 2017

30

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6 November 2017

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6 November 2017

1248-1256

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https://scigraph.springernature.com/pub.10.1007/s10637-010-9626-9

6 November 2017

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Irinotecan plus fluorouracil/leucovorin for metastatic colorectal cancer: a new survival standard.

21 January 2018

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Role of non-homologous end joining (NHEJ) in maintaining genomic integrity

21 January 2018

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Optimal delivery of cytotoxic chemotherapy for colon cancer

21 January 2018

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Oxaliplatin activity in selected and unselected human ovarian and colorectal cancer cell lines

21 January 2018

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DNA repair enzyme, O6-methylguanine DNA methyltransferase, modulates cytotoxicity of camptothecin-derived topoisomerase I inhibitors

21 January 2018

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Oxaliplatin for the treatment of cisplatin-resistant cancer: a systematic review

21 January 2018

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Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis

21 January 2018

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The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway

21 January 2018

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Hierarchy of nonhomologous end-joining, single-strand annealing and gene conversion at site-directed DNA double-strand breaks

21 January 2018

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DNA-dependent protein kinase is a molecular target for the development of noncytotoxic radiation-sensitizing drugs

21 January 2018

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Impaired NHEJ function in multiple myeloma

21 January 2018

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A novel DNA-dependent protein kinase inhibitor, NU7026, potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia

21 January 2018

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Chlorambucil cytotoxicity in malignant B lymphocytes is synergistically increased by 2-(morpholin-4-yl)-benzo[h]chomen-4-one (NU7026)-mediated inhibition of DNA double-strand break repair via inhibition of DNA-dependent protein kinase

21 January 2018

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Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks

21 January 2018

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Genome signatures of colon carcinoma cell lines

21 January 2018

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Sulforhodamine B colorimetric assay for cytotoxicity screening.

21 January 2018

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XRCC3 promotes homology-directed repair of DNA damage in mammalian cells

21 January 2018

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Autophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks

21 January 2018

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DNA damage signaling in response to double-strand breaks during mitosis

21 January 2018

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ATM- and ATR-mediated response to DNA damage induced by a novel camptothecin, ST1968.

21 January 2018

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Distinct roles of ATR and DNA-PKcs in triggering DNA damage responses in ATM-deficient cells

21 January 2018

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DNA-PK suppresses a p53-independent apoptotic response to DNA damage

21 January 2018

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Molecular mechanisms of resistance and toxicity associated with platinating agents

21 January 2018

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Cisplatin induces endoplasmic reticulum stress and nucleus-independent apoptotic signaling

21 January 2018

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Cell cycle dependence of DNA-dependent protein kinase phosphorylation in response to DNA double strand breaks.

21 January 2018

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Induction of biphasic DNA double strand breaks and activation of multiple repair protein complexes by DNA topoisomerase I drug 7-ethyl-10-hydroxy-camptothecin

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DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?

21 January 2018

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ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation

21 January 2018

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DNA-PK is activated by nucleosomes and phosphorylates H2AX within the nucleosomes in an acetylation-dependent manner

21 January 2018

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Tissue-specific DNA-PK-dependent H2AX phosphorylation and gamma-H2AX elimination after X-irradiation in vivo.

21 January 2018

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Substrate specificities and identification of putative substrates of ATM kinase family members

21 January 2018

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ATM, ATR and DNA-PK: initiators of the cellular genotoxic stress responses.

21 January 2018

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ATR-dependent phosphorylation of DNA-dependent protein kinase catalytic subunit in response to UV-induced replication stress

21 January 2018

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DNA-PKcs and ATM co-regulate DNA double-strand break repair

21 January 2018

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Cellular response to DNA damage

21 January 2018

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DNA double-strand break formation upon UV-induced replication stress activates ATM and DNA-PKcs kinases

21 January 2018

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12 December 2020

Preclinical pharmacokinetics and metabolism of a novel prototype DNA-PK inhibitor NU7026

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12 December 2020

Heterogeneity of malignant cells from a human colonic carcinoma.

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12 December 2020

Effective conversion of irinotecan to SN-38 after intratumoral drug delivery to an intracranial murine glioma model in vivo. Laboratory investigation

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12 December 2020

Threonines 2638/2647 in DNA-PK are essential for cellular resistance to ionizing radiation

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12 December 2020

Emergence of permanently differentiated cell clones in a human colonic cancer cell line in culture after treatment with sodium butyrate

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12 December 2020

Inhibition of poly(ADP-ribose) polymerase prevents irinotecan-induced intestinal damage and enhances irinotecan/temozolomide efficacy against colon carcinoma

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12 December 2020

DNA-PKcs plays a dominant role in the regulation of H2AX phosphorylation in response to DNA damage and cell cycle progression

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12 December 2020

The comet assay: a method to measure DNA damage in individual cells

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12 December 2020

Re: W. R. Greco et al., Application of a new approach for the quantitation of drug synergism to the combination of cis-diamminedichloroplatinum and 1-beta-D-arabinofuranosylcytosine. Cancer Res., 50: 5318-5327, 1990.

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12 December 2020

10.1007/S10637-010-9626-9

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Dimensions Publication ID

6 November 2017

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