Simultaneous downregulation of CDK inhibitors p18(Ink4c) and p27(Kip1) is required for MEN2A-RET-mediated mitogenesis (Q42796164)

7 November 2017

Simultaneous downregulation of CDK inhibitors p18(Ink4c) and p27(Kip1) is required for MEN2A-RET-mediated mitogenesis (English)

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7 November 2017

Joshi PP

1

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7 November 2017

Kulkarni MV

2

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7 November 2017

Yu BK

3

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7 November 2017

Smith KR

4

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7 November 2017

Norton DL

5

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7 November 2017

van Veelen W

6

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7 November 2017

Höppener JW

7

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7 November 2017

Franklin DS

8

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7 November 2017

language of work or name

English

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publication date

4 September 2006

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7 November 2017

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7 November 2017

26

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7 November 2017

4

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7 November 2017

554-570

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1209811

7 November 2017

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Reduced p18INK4c, p21CIP1/WAF1 and p27KIP1 mRNA levels in tumours of primary and secondary hyperparathyroidism.

21 January 2018

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H4(D10S170), a gene frequently rearranged with RET in papillary thyroid carcinomas: functional characterization.

21 January 2018

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Regulation of cyclin-dependent kinase (Cdk) 2 Thr-160 phosphorylation and activity by mitogen-activated protein kinase in late G1 phase

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Requirement of p27Kip1 for restriction point control of the fibroblast cell cycle

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RAS and RHO GTPases in G1-phase cell-cycle regulation

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Mitotic activity of the endocrine cells in rat thyroid glands during postnatal life

21 January 2018

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Role of MEN2A-derived RET in maintenance and proliferation of medullary thyroid carcinoma.

21 January 2018

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The relationship between specific RET proto-oncogene mutations and disease phenotype in multiple endocrine neoplasia type 2. International RET mutation consortium analysis

21 January 2018

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A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice

21 January 2018

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CDK inhibitors p18(INK4c) and p27(Kip1) mediate two separate pathways to collaboratively suppress pituitary tumorigenesis

21 January 2018

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Functional collaboration between different cyclin-dependent kinase inhibitors suppresses tumor growth with distinct tissue specificity

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Induction of p18INK4c and its predominant association with CDK4 and CDK6 during myogenic differentiation

21 January 2018

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An analysis of Mek1 signaling in cell proliferation and transformation

21 January 2018

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Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF.

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Inactivation of the cyclin D-dependent kinase in the rat fibroblast cell line, 3Y1, induced by contact inhibition

21 January 2018

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Induction of p27Kip1 degradation and anchorage independence by Ras through the MAP kinase signaling pathway.

21 January 2018

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Identification of RET autophosphorylation sites by mass spectrometry

21 January 2018

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Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1).

21 January 2018

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The RET proto-oncogene: a molecular therapeutic target in thyroid cancer

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To cycle or not to cycle: a critical decision in cancer.

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Molecular and biochemical characterization of the human trk proto-oncogene

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Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A.

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Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors

21 January 2018

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Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27

21 January 2018

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Coupled transcriptional and translational control of cyclin-dependent kinase inhibitor p18INK4c expression during myogenesis

21 January 2018

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p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest

21 January 2018

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Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a

21 January 2018

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Activation of RET as a dominant transforming gene by germline mutations of MEN2A and MEN2B

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An epidermal growth factor receptor/ret chimera generates mitogenic and transforming signals: evidence for a ret-specific signaling pathway

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MEN2A-RET-induced cellular transformation by activation of STAT3

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CDK inhibitors: positive and negative regulators of G1-phase progression

21 January 2018

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Ret-dependent and -independent mechanisms of glial cell line-derived neurotrophic factor signaling in neuronal cells

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Regulation of p27Kip1 protein levels contributes to mitogenic effects of the RET/PTC kinase in thyroid carcinoma cells.

21 January 2018

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Characterization of gene expression induced by RET with MEN2A or MEN2B mutation

21 January 2018

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Glial cell line-derived neurotrophic factor signals through the RET receptor and activates mitogen-activated protein kinase

21 January 2018

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NGF Binding to the trk Tyrosine Kinase Receptor Requires the Extracellular Immunoglobulin-like Domains

21 January 2018

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Biological and biochemical properties of Ret with kinase domain mutations identified in multiple endocrine neoplasia type 2B and familial medullary thyroid carcinoma

21 January 2018

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7 January 2021

Noradrenergic-specific transcription of the dopamine beta-hydroxylase gene requires synergy of multiple cis-acting elements including at least two Phox2a-binding sites.

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7 January 2021

RET proto-oncogene mutations in multiple endocrine neoplasia type 2 and medullary thyroid carcinoma

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7 January 2021

Chromaffin cell proliferation in the adult rat adrenal medulla

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7 January 2021

Signal transduction by the receptor tyrosine kinase Ret.

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7 January 2021

Ras-stimulated extracellular signal-related kinase 1 and RhoA activities coordinate platelet-derived growth factor-induced G1 progression through the independent regulation of cyclin D1 and p27

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1209811

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Dimensions Publication ID

7 November 2017

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1 reference