Anti-apoptotic and oncogenic properties of the dsRNA-binding protein of vaccinia virus, E3L. (Q42807639)

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15 December 2019

title

Anti-apoptotic and oncogenic properties of the dsRNA-binding protein of vaccinia virus, E3L (English)

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15 December 2019

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vaccinia virus

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1

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15 December 2019

Jesus Gil

series ordinal

3

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15 December 2019

5

Mariano Esteban

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15 December 2019

author name string

Susana Guerra

series ordinal

2

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15 December 2019

Victoria Jimenez

series ordinal

4

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15 December 2019

language of work or name

English

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publication date

1 December 2002

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15 December 2019

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15 December 2019

volume

21

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15 December 2019

issue

55

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15 December 2019

page(s)

8379-8387

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1206036

15 December 2019

exact match

0 references

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Both carboxy- and amino-terminal domains of the vaccinia virus interferon resistance gene, E3L, are required for pathogenesis in a mouse model

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Reversal of the interferon-sensitive phenotype of a vaccinia virus lacking E3L by expression of the reovirus S4 gene.

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Host-range restriction of vaccinia virus E3L-specific deletion mutants

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Oncogenic potential of TAR RNA binding protein TRBP and its regulatory interaction with RNA-dependent protein kinase PKR.

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A study of the interferon antiviral mechanism: apoptosis activation by the 2-5A system

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The E3L gene of vaccinia virus encodes an inhibitor of the interferon-induced, double-stranded RNA-dependent protein kinase

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JNK2 and IKKbeta are required for activating the innate response to viral infection

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Double-stranded-RNA-activated protein kinase PKR enhances transcriptional activation by tumor suppressor p53

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The double-stranded RNA activated protein kinase PKR physically associates with the tumor suppressor p53 protein and phosphorylates human p53 on serine 392 in vitro

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The E3L and K3L vaccinia virus gene products stimulate translation through inhibition of the double-stranded RNA-dependent protein kinase by different mechanisms

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A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis

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7 January 2021

Identification of genes differentially regulated by interferon alpha, beta, or gamma using oligonucleotide arrays

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Activation of the IFN-inducible enzyme RNase L causes apoptosis of animal cells.

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A comprehensive view of regulation of gene expression by double-stranded RNA-mediated cell signaling

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NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses

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Induction of the human protein P56 by interferon, double-stranded RNA, or virus infection

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The IRF-3 transcription factor mediates Sendai virus-induced apoptosis

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When two strands are better than one: the mediators and modulators of the cellular responses to double-stranded RNA.

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Abnormal levels and minimal activity of the dsRNA-activated protein kinase, PKR, in breast carcinoma cells

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Activation of interferon regulatory factor 3 in response to DNA-damaging agents

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Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase

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7 January 2021

The interferon-induced double-stranded RNA-activated human p68 protein kinase inhibits the replication of vaccinia virus

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7 January 2021

The interferon-induced double-stranded RNA-activated protein kinase induces apoptosis

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7 January 2021

Regulated expression of the interferon-induced protein kinase p68 (PKR) by vaccinia virus recombinants inhibits the replication of vesicular stomatitis virus but not that of poliovirus

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7 January 2021

Binding of the influenza virus NS1 protein to double-stranded RNA inhibits the activation of the protein kinase that phosphorylates the elF-2 translation initiation factor

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7 January 2021

Resistance of vaccinia virus to interferon is related to an interference phenomenon between the virus and the interferon system

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7 January 2021

TAR RNA-binding protein is an inhibitor of the interferon-induced protein kinase PKR

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7 January 2021

The human 2',5'-oligoadenylate synthetase family: interferon-induced proteins with unique enzymatic properties

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7 January 2021

Vaccinia virus E3L protein is an inhibitor of the interferon (i.f.n.)-induced 2-5A synthetase enzyme.

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7 January 2021

Inhibition of double-stranded RNA-dependent protein kinase PKR by vaccinia virus E3: role of complex formation and the E3 N-terminal domain

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7 January 2021

Molecular mechanisms underlying interferon-alpha-induced G0/G1 arrest: CKI-mediated regulation of G1 Cdk-complexes and activation of pocket proteins

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7 January 2021

The vaccinia virus E3L gene product interacts with both the regulatory and the substrate binding regions of PKR: implications for PKR autoregulation

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7 January 2021

G1 phase progression: cycling on cue

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IRF3 and IRF7 phosphorylation in virus-infected cells does not require double-stranded RNA-dependent protein kinase R or Ikappa B kinase but is blocked by Vaccinia virus E3L protein

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Characterization of a vaccinia virus-encoded double-stranded RNA-binding protein that may be involved in inhibition of the double-stranded RNA-dependent protein kinase

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7 January 2021

PKR; a sentinel kinase for cellular stress

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7 January 2021

Blockade of interferon induction and action by the E3L double-stranded RNA binding proteins of vaccinia virus.

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7 January 2021

Two molecularly distinct G(2)/M checkpoints are induced by ionizing irradiation

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7 January 2021

Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase

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7 January 2021

Nuclear localization of a double-stranded RNA-binding protein encoded by the vaccinia virus E3L gene

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7 January 2021

Interferon action and apoptosis are defective in mice devoid of 2',5'-oligoadenylate-dependent RNase L

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7 January 2021

Interferon action in triply deficient mice reveals the existence of alternative antiviral pathways.

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1206036

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12466958%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

15 December 2019

0 references

1 reference