c-Kit is required for growth and survival of the cells of origin of Brca1-mutation-associated breast cancer. (Q42808096)

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7 February 2020

title

c-Kit is required for growth and survival of the cells of origin of Brca1-mutation-associated breast cancer (English)

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7 February 2020

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1

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7 February 2020

Vida Vafaizadeh

4

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7 February 2020

Matthew J Smalley

6

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7 February 2020

author name string

H Kendrick

2

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7 February 2020

F-A Magnay

3

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7 February 2020

B Groner

5

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7 February 2020

language of work or name

English

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publication date

18 July 2011

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7 February 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21765473%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

volume

31

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7 February 2020

issue

7

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7 February 2020

page(s)

869-883

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https://scigraph.springernature.com/pub.10.1038/onc.2011.289

7 February 2020

exact match

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cites work

Heregulin induces phosphorylation of BRCA1 through phosphatidylinositol 3-Kinase/AKT in breast cancer cells

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Prolactin-induced mouse mammary carcinomas model estrogen resistant luminal breast cancer

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Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation

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Spotlight on spotted mice: a review of white spotting mouse mutants and associated human pigmentation disorders

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Steel-Dickie mutation encodes a c-kit ligand lacking transmembrane and cytoplasmic domains

21 January 2018

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Pregnancy in the mature adult mouse does not alter the proportion of mammary epithelial stem/progenitor cells

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STAT protein recruitment and activation in c-Kit deletion mutants

21 January 2018

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Isoforms of c-KIT differ in activation of signalling pathways and transformation of NIH3T3 fibroblasts

21 January 2018

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Stat1 associates with c-kit and is activated in response to stem cell factor

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Stem cells in normal breast development and breast cancer

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Membrane-bound stem cell factor is a key regulator in the initial lodgment of stem cells within the endosteal marrow region.

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Mapping mammary gland architecture using multi-scale in situ analysis

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Constitutive activation of JAK-STAT3 signaling by BRCA1 in human prostate cancer cells

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Phosphatidylinositol 3-kinase and Ca2+ influx dependence for ligand-stimulated internalization of the c-Kit receptor.

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Basal cytokeratins and their relationship to the cellular origin and functional classification of breast cancer

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Exon skipping by mutation of an authentic splice site of c-kit gene in W/W mouse

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Bifurcation dynamics in lineage-commitment in bipotent progenitor cells

21 January 2018

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Transcriptome analysis of mammary epithelial subpopulations identifies novel determinants of lineage commitment and cell fate

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Regulation of hematopoietic stem cells by the steel factor/KIT signaling pathway

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Mast cells contribute to the stromal microenvironment in mammary gland branching morphogenesis

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Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers

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Lyn associates with the juxtamembrane region of c-Kit and is activated by stem cell factor in hematopoietic cell lines and normal progenitor cells

21 January 2018

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Paracrine signaling through the epithelial estrogen receptor alpha is required for proliferation and morphogenesis in the mammary gland

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Molecular evidence for hierarchical transcriptional lineage priming in fetal and adult stem cells and multipotent progenitors.

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BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells

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Mammary stem cells and breast cancer.

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Collaboration of signal transducer and activator of transcription 1 (STAT1) and BRCA1 in differential regulation of IFN-gamma target genes

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The protein-tyrosine kinase Lck associates with and is phosphorylated by Cdc2

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.289

Structure and regulation of Kit protein-tyrosine kinase--the stem cell factor receptor

21 January 2018

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Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor

21 January 2018

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Generation of a functional mammary gland from a single stem cell

21 January 2018

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Lyn contributes to regulation of multiple Kit-dependent signaling pathways in murine bone marrow mast cells

21 January 2018

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Dissociation of estrogen receptor expression and in vivo stem cell activity in the mammary gland

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CD24 staining of mouse mammary gland cells defines luminal epithelial, myoepithelial/basal and non-epithelial cells

21 January 2018

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Analysis of Brca1-deficient mouse mammary glands reveals reciprocal regulation of Brca1 and c-kit.

21 January 2018

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Gab2 is involved in differential phosphoinositide 3-kinase signaling by two splice forms of c-Kit

21 January 2018

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Beta1 integrin deletion from the basal compartment of the mammary epithelium affects stem cells

21 January 2018

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BRCA1 and BRCA2 bind Stat5a and suppress its transcriptional activity

21 January 2018

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Src family kinases are involved in the differential signaling from two splice forms of c-Kit

21 January 2018

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BRCA1 proteins are transported to the nucleus in the absence of serum and splice variants BRCA1a, BRCA1b are tyrosine phosphoproteins that associate with E2F, cyclins and cyclin dependent kinases

21 January 2018

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Genome-wide transcriptomic profiling of microdissected human breast tissue reveals differential expression of KIT (c-Kit, CD117) and oestrogen receptor-alpha (ERalpha) in response to therapeutic radiation

21 January 2018

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Early myeloid cells expressing c-KIT isoforms differ in signal transduction, survival and chemotactic responses to Stem Cell Factor

21 January 2018

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The scaffolding adapter Gab2, via Shp-2, regulates kit-evoked mast cell proliferation by activating the Rac/JNK pathway.

21 January 2018

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Purification and unique properties of mammary epithelial stem cells

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31 March 2020

Identifiers

DOI

10.1038/ONC.2011.289

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21765473%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

7 February 2020

1004491684

0 references

1 reference