The scaffolding adapter Gab2, via Shp-2, regulates kit-evoked mast cell proliferation by activating the Rac/JNK pathway. (Q50336720)

5 March 2018

title

The scaffolding adapter Gab2, via Shp-2, regulates kit-evoked mast cell proliferation by activating the Rac/JNK pathway. (English)

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5 March 2018

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Min Yu

1

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5 March 2018

Jincai Luo

2

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5 March 2018

Wentian Yang

3

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5 March 2018

Yongping Wang

4

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5 March 2018

Masao Mizuki

5

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5 March 2018

Yuzuru Kanakura

6

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5 March 2018

Peter Besmer

7

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5 March 2018

Benjamin G Neel

8

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5 March 2018

Haihua Gu

9

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5 March 2018

language of work or name

English

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publication date

27 July 2006

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5 March 2018

Journal of Biological Chemistry

number of pages

12

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based on heuristic

inferred from page(s)

published in

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5 March 2018

volume

281

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5 March 2018

page(s)

28615-28626

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5 March 2018

issue

39

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5 March 2018

cites work

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Kit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation

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Critical role for Kit-mediated Src kinase but not PI 3-kinase signaling in pro T and pro B cell development

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Rac2 stimulates Akt activation affecting BAD/Bcl-XL expression while mediating survival and actin function in primary mast cells

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Scaffolding adapter Grb2-associated binder 2 requires Syk to transmit signals from FcepsilonRI

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Identification of an atypical Grb2 carboxyl-terminal SH3 domain binding site in Gab docking proteins reveals Grb2-dependent and -independent recruitment of Gab1 to receptor tyrosine kinases

21 January 2018

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21 January 2018

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Scaffolding protein Gab2 mediates differentiation signaling downstream of Fms receptor tyrosine kinase

21 January 2018

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Participation of both Gab1 and Gab2 in the activation of the ERK/MAPK pathway by epidermal growth factor

21 January 2018

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Increased proliferation and altered growth factor dependence of human mammary epithelial cells overexpressing the Gab2 docking protein

21 January 2018

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A role for the scaffolding adapter GAB2 in breast cancer

21 January 2018

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21 January 2018

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21 January 2018

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Essential role for Gab2 in the allergic response

21 January 2018

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The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis

21 January 2018

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Requirement of Gab2 for mast cell development and KitL/c-Kit signaling

21 January 2018

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An Shp2/SFK/Ras/Erk signaling pathway controls trophoblast stem cell survival

21 January 2018

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21 January 2018

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Plat-E: an efficient and stable system for transient packaging of retroviruses

21 January 2018

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Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton

21 January 2018

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Phosphorylation of protein-tyrosine phosphatase PTP-1B on identical sites suggests activation of a common signaling pathway during mitosis and stress response in mammalian cells

21 January 2018

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SU6656, a selective src family kinase inhibitor, used to probe growth factor signaling

21 January 2018

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Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130

21 January 2018

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Targeted mutations of the juxtamembrane tyrosines in the Kit receptor tyrosine kinase selectively affect multiple cell lineages

21 January 2018

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Scansite 2.0: Proteome-wide prediction of cell signaling interactions using short sequence motifs

21 January 2018

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Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptor

21 January 2018

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SHP-2 positively regulates myogenesis by coupling to the Rho GTPase signaling pathway

21 January 2018

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GC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2

21 January 2018

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Gab1 and SHP-2 promote Ras/MAPK regulation of epidermal growth and differentiation

21 January 2018

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A novel role for Gab1 and SHP2 in epidermal growth factor-induced Ras activation

21 January 2018

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Selective loss of gastrointestinal mast cells and impaired immunity in PI3K-deficient mice

21 January 2018

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Signaling interplay in Ras superfamily function

21 January 2018

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Role of the docking protein Gab2 in beta(1)-integrin signaling pathway-mediated hematopoietic cell adhesion and migration

21 January 2018

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Intestinal mast cell progenitors require CD49dbeta7 (alpha4beta7 integrin) for tissue-specific homing

21 January 2018

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Rho and Rac take center stage

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M603742200

Identification of mast cell progenitors in adult mice

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M603742200

1 reference

5 March 2018

PubMed ID

16873377

1 reference

5 March 2018